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Entry version 184 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

GTP:AMP phosphotransferase, mitochondrial

Gene

Ak3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36AMPUniRule annotation1
Binding sitei41AMPUniRule annotation1
Binding sitei96AMPUniRule annotation1
Binding sitei126GTPUniRule annotation1
Binding sitei159AMPUniRule annotation1
Binding sitei170AMPUniRule annotation1
Binding sitei199GTP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 20GTPUniRule annotation6
Nucleotide bindingi62 – 64AMPUniRule annotation3
Nucleotide bindingi89 – 92AMPUniRule annotation4
Nucleotide bindingi135 – 136GTPUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImportedARBA annotation, Transferase
LigandGTP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-499943, Interconversion of nucleotide di- and triphosphates
R-DME-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP:AMP phosphotransferase, mitochondrialUniRule annotation (EC:2.7.4.10UniRule annotation)
Alternative name(s):
Adenylate kinase 3UniRule annotation
Short name:
AK 3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ak3Imported
Synonyms:Adk3UniRule annotationImported, AK3Imported, bs12h03.y1Imported, DAK3Imported, Dak3Imported, Dmel\CG6612Imported
ORF Names:CG6612Imported, Dmel_CG6612Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0042094, Ak3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MitochondrionUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0042094, Expressed in arthropod fat body and 36 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VGU6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081807

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 161ADK_lidInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 64NMPbindUniRule annotationAdd BLAST30
Regioni125 – 162LIDUniRule annotationAdd BLAST38

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylate kinase family. AK3 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3078, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155120

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032354_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKNRWIH

Database of Orthologous Groups

More...
OrthoDBi
1004067at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01428, ADK, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00235, Adenylate_kinase_Adk, 1 hit
MF_03169, Adenylate_kinase_AK3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006259, Adenyl_kin_sub
IPR000850, Adenylat/UMP-CMP_kin
IPR033690, Adenylat_kinase_CS
IPR007862, Adenylate_kinase_lid-dom
IPR036193, ADK_active_lid_dom_sf
IPR028586, AK3/Ak4_mitochondrial
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR23359, PTHR23359, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05191, ADK_lid, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00094, ADENYLTKNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF57774, SSF57774, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01351, adk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00113, ADENYLATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VGU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTKIFRAVI IGAPGSGKGT ISELICKNHG CVHISTGDIL RQNIIKNTEL
60 70 80 90 100
GKKAKQYIAE GKLVPDAIVT KTMLARITEV GNRSYILDGF PRNIAQAEAL
110 120 130 140 150
AAREQIDAVI TLDVPHSVII DRVKNRWIHA PSGRVYNIGF KNPKVPGKDD
160 170 180 190 200
VTGEPLMQRE DDKPHVVAKR LELYDEVMSP VIAWYEKKGL VATFKGKQTK
210
EIWPMMELFL NDRINA
Length:216
Mass (Da):24,145
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AB49A756D23091B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54578.1
AE014297 Genomic DNA Translation: AAN13494.1
BT015244 mRNA Translation: AAT94473.1
AE014297 Genomic DNA Translation: AHN57278.1
AE014297 Genomic DNA Translation: AHN57279.1
AB050622 mRNA Translation: BAB44152.1

NCBI Reference Sequences

More...
RefSeqi
NP_001287279.1, NM_001300350.1
NP_001287280.1, NM_001300351.1
NP_524312.1, NM_079588.3
NP_731529.1, NM_169373.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082330; FBpp0081806; FBgn0042094
FBtr0082331; FBpp0081807; FBgn0042094
FBtr0339378; FBpp0308469; FBgn0042094
FBtr0339379; FBpp0308470; FBgn0042094

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41318

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6612

UCSC genome browser

More...
UCSCi
CG6612-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54578.1
AE014297 Genomic DNA Translation: AAN13494.1
BT015244 mRNA Translation: AAT94473.1
AE014297 Genomic DNA Translation: AHN57278.1
AE014297 Genomic DNA Translation: AHN57279.1
AB050622 mRNA Translation: BAB44152.1
RefSeqiNP_001287279.1, NM_001300350.1
NP_001287280.1, NM_001300351.1
NP_524312.1, NM_079588.3
NP_731529.1, NM_169373.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VGU6, 1 interactor
STRINGi7227.FBpp0081807

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
41318

Genome annotation databases

EnsemblMetazoaiFBtr0082330; FBpp0081806; FBgn0042094
FBtr0082331; FBpp0081807; FBgn0042094
FBtr0339378; FBpp0308469; FBgn0042094
FBtr0339379; FBpp0308470; FBgn0042094
GeneIDi41318
KEGGidme:Dmel_CG6612
UCSCiCG6612-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41318
FlyBaseiFBgn0042094, Ak3

Phylogenomic databases

eggNOGiKOG3078, Eukaryota
GeneTreeiENSGT00940000155120
HOGENOMiCLU_032354_1_1_1
OMAiVKNRWIH
OrthoDBi1004067at2759

Enzyme and pathway databases

ReactomeiR-DME-499943, Interconversion of nucleotide di- and triphosphates
R-DME-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41318, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41318

Gene expression databases

BgeeiFBgn0042094, Expressed in arthropod fat body and 36 other tissues

Family and domain databases

CDDicd01428, ADK, 1 hit
HAMAPiMF_00235, Adenylate_kinase_Adk, 1 hit
MF_03169, Adenylate_kinase_AK3, 1 hit
InterProiView protein in InterPro
IPR006259, Adenyl_kin_sub
IPR000850, Adenylat/UMP-CMP_kin
IPR033690, Adenylat_kinase_CS
IPR007862, Adenylate_kinase_lid-dom
IPR036193, ADK_active_lid_dom_sf
IPR028586, AK3/Ak4_mitochondrial
IPR027417, P-loop_NTPase
PANTHERiPTHR23359, PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191, ADK_lid, 1 hit
PRINTSiPR00094, ADENYLTKNASE
SUPFAMiSSF52540, SSF52540, 1 hit
SSF57774, SSF57774, 1 hit
TIGRFAMsiTIGR01351, adk, 1 hit
PROSITEiView protein in PROSITE
PS00113, ADENYLATE_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VGU6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VGU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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