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Entry version 141 (16 Oct 2019)
Sequence version 2 (01 Jun 2003)
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Protein

Tetratricopeptide repeat protein 14 homolog

Gene

CG6621

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 14 homolog
Short name:
TPR repeat protein 14 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG6621
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037855 CG6621

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003726511 – 872Tetratricopeptide repeat protein 14 homologAdd BLAST872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei536Phosphoserine1 Publication1
Modified residuei538Phosphothreonine2 Publications1
Modified residuei540Phosphoserine2 Publications1
Modified residuei606Phosphoserine1 Publication1
Modified residuei607Phosphoserine1 Publication1
Modified residuei769Phosphoserine1 Publication1
Modified residuei771Phosphoserine1 Publication1
Modified residuei778Phosphoserine1 Publication1
Modified residuei780Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VGU5

PRoteomics IDEntifications database

More...
PRIDEi
Q9VGU5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VGU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037855 Expressed in 24 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VGU5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VGU5 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66462, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VGU5, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081805

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati302 – 335TPR 1Add BLAST34
Repeati336 – 369TPR 2Add BLAST34
Repeati377 – 410TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi446 – 454Poly-Ser9
Compositional biasi516 – 531Lys-richAdd BLAST16
Compositional biasi590 – 595Poly-Pro6
Compositional biasi679 – 829Arg-richAdd BLAST151
Compositional biasi680 – 809Ser-richAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC14 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGWP Eukaryota
ENOG410XQJ7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013701

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VGU5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCNNQIA

Database of Orthologous Groups

More...
OrthoDBi
374271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VGU5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039190 TTC14

The PANTHER Classification System

More...
PANTHERi
PTHR23184 PTHR23184, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VGU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFDYIGQAL GYHGQPLQKI WDDERGVDDL RLMGLTQVNY GVYQERQKYF
60 70 80 90 100
TFQERAKRLK MHQFLARKAT DLYDRTLVAN VMEDSLLAQG NTYMTQMAPF
110 120 130 140 150
EFFLNVKDKR KGWAHRLSAL KQGDIIYTQV TRLASGNRLI VKPLCTAEPK
160 170 180 190 200
HAYLADIPIK AVILQDFWGP LPLDKQGNPR SFVQNDILRC EINNISADTE
210 220 230 240 250
RLSLNMIGMF NKVPDLKFGL CDFKELPKYY SKIHNLDHPS ASHYEDELNK
260 270 280 290 300
ALEFENPNYD LLFQMNGLQP NENLSLMSYL RAGFPEEENA AELRQKQASQ
310 320 330 340 350
WAFRSVADGI EHFKNGQQVE AFQCLNKALN IDPRNVEALV ARGALYANRG
360 370 380 390 400
SFLKGLQDFE KALHLNKYHV NARKYMGETL VALGRSYEEE NRIAEAVKAY
410 420 430 440 450
SDCLNLLPLH EEARQSLDAL HRSGDGKRRI STEPSNMTGG QSSDESSSSS
460 470 480 490 500
ASDSECEDSA GKPKSNISQP FYAQHKLKQS GDEKLAVIDA HKANEFRLDD
510 520 530 540 550
DETVSSVRKL LREASKHKKA KKKGKKKKDK KERRRSRTKS ETEDPIELLK
560 570 580 590 600
KIDFQEALRQ DNKLMNSTRS DEERKAKIKS YLKEGGKESP PPPPPMKKTA
610 620 630 640 650
VSSRKSSFDN VGPSTSRHAA SVVGFGGAQP PPAPKFLGQK KHPEPAPKLS
660 670 680 690 700
FQIKKRPLQM DKLGMLRLAA PAEPLKGGRS SSSRSRSRSR SRSRSRSRNR
710 720 730 740 750
RLGRSTRSSL RSRRSGSRSR SISRSRSRRR RTYSRSRSPS PRSYGNRFVI
760 770 780 790 800
GRYRNRRTRR SRSFHRRRSP SPILKRRSPS PFVPRRTPSP ASRYRRSRSR
810 820 830 840 850
SRSRSRSRSP RRFQSRYMPR DRGSVNRSRY SWHNPHKRSV SRTVEPNGKD
860 870
ERAATPPKKG VADDRSGREE RA
Length:872
Mass (Da):99,870
Last modified:June 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC80043E033AF3C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4JDC3A0A0B4JDC3_DROME
Uncharacterized protein, isoform B
Dmel\CG6621 TTC14, CG6621, Dmel_CG6621
868Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti718R → G in AAM27513 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54579.2
AY102684 mRNA Translation: AAM27513.1
BT044217 mRNA Translation: ACH92282.1

NCBI Reference Sequences

More...
RefSeqi
NP_650036.2, NM_141779.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082329; FBpp0081805; FBgn0037855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6621

UCSC genome browser

More...
UCSCi
CG6621-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54579.2
AY102684 mRNA Translation: AAM27513.1
BT044217 mRNA Translation: ACH92282.1
RefSeqiNP_650036.2, NM_141779.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi66462, 4 interactors
IntActiQ9VGU5, 5 interactors
STRINGi7227.FBpp0081805

PTM databases

iPTMnetiQ9VGU5

Proteomic databases

PaxDbiQ9VGU5
PRIDEiQ9VGU5

Genome annotation databases

EnsemblMetazoaiFBtr0082329; FBpp0081805; FBgn0037855
GeneIDi41319
KEGGidme:Dmel_CG6621
UCSCiCG6621-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0037855 CG6621

Phylogenomic databases

eggNOGiENOG410IGWP Eukaryota
ENOG410XQJ7 LUCA
GeneTreeiENSGT00390000013701
InParanoidiQ9VGU5
OMAiSCNNQIA
OrthoDBi374271at2759
PhylomeDBiQ9VGU5

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41319

Protein Ontology

More...
PROi
PR:Q9VGU5

Gene expression databases

BgeeiFBgn0037855 Expressed in 24 organ(s), highest expression level in embryo
ExpressionAtlasiQ9VGU5 baseline and differential
GenevisibleiQ9VGU5 DM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039190 TTC14
PANTHERiPTHR23184 PTHR23184, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC14_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VGU5
Secondary accession number(s): Q8MZH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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