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Entry version 126 (16 Oct 2019)
Sequence version 2 (05 Jul 2004)
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Protein

PigN domain-containing protein

Gene

anon-WO0140519.186

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PigN domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:anon-WO0140519.186Imported
Synonyms:Dmel\CG6790Imported, NEST:bs22e02Imported
ORF Names:CG6790Imported, Dmel_CG6790Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037915 CG6790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei46 – 63HelicalSequence analysisAdd BLAST18
Transmembranei424 – 442HelicalSequence analysisAdd BLAST19
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Transmembranei529 – 553HelicalSequence analysisAdd BLAST25
Transmembranei565 – 581HelicalSequence analysisAdd BLAST17
Transmembranei593 – 612HelicalSequence analysisAdd BLAST20
Transmembranei618 – 637HelicalSequence analysisAdd BLAST20
Transmembranei644 – 663HelicalSequence analysisAdd BLAST20
Transmembranei733 – 756HelicalSequence analysisAdd BLAST24
Transmembranei776 – 800HelicalSequence analysisAdd BLAST25
Transmembranei812 – 831HelicalSequence analysisAdd BLAST20
Transmembranei843 – 867HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VGM0

PRoteomics IDEntifications database

More...
PRIDEi
Q9VGM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037915 Expressed in 10 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VGM0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VGM0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081936

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini417 – 830PigNInterPro annotationAdd BLAST414

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2124 Eukaryota
COG1524 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VGM0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKVSREY

Database of Orthologous Groups

More...
OrthoDBi
270107at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VGM0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16020 GPI_EPT_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR007070 GPI_EtnP_transferase_1
IPR017852 GPI_EtnP_transferase_1_C
IPR037671 PIGN_N

The PANTHER Classification System

More...
PANTHERi
PTHR12250 PTHR12250, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04987 PigN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649 SSF53649, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VGM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLALLQTFL WCFFSVVVNV SFVLYRRLTY RLVGKVQVLM ELWKSKVVLV
60 70 80 90 100
HLLLLICIMR IFYQSGPLSQ LEPQKTLLDM GVPPAADRLV VFLLEGLRAD
110 120 130 140 150
TLFSDNCSGA VYIRDIILRQ GLVGISKTSV PTLTRSAEVA LFAGFNPMPS
160 170 180 190 200
ILPTSNFDTI FNRTLAFDKG AFLRFSHLSD LRRRLTKRAC LEKLWYANKL
210 220 230 240 250
VMLVNLAEVG GASPLDIGFQ MKLHNTQRNI RDAYELIEAT FNDSKTAYLY
260 270 280 290 300
TSAHGLTYFG SHGGGSDEER EAPFLLWGAG VKHVTENITS DFVLNNGVGM
310 320 330 340 350
QLHKLDQIQL APLMSALIGL PPPVNNLAIL PQGYMKVSRE YARKSVHLNA
360 370 380 390 400
LQLLTQAKAI IRLHERGVFH KWLPKDKDLD LQQIAYYQNQ MDHLLDMGWR
410 420 430 440 450
SKALETSTLA IKVALKSLKF YHNYYHIPLV VTTVLALLGW QFYQLVKLSQ
460 470 480 490 500
NVMAPHYMRR GYLTWCTIFL ASLGLLLGEM VFLQWAPFMT VICLVVPFGV
510 520 530 540 550
WCMTLAALPQ NGGWIFEPLK HLRWIVGPAA VMIASIYCNC PLSLAYILCV
560 570 580 590 600
GFYNRRGWLH PSPKFLAWLA LVLLLGGFLW SQKGMQILMT TNYRVVLQAI
610 620 630 640 650
SMLVVIVRPC VLNENHKWKV WVINGGILFV AAIGIFLKEM GKPVPLYLFA
660 670 680 690 700
ANWAYLIYAF ASVPCSSRTT PQSRLELIRF NLLTLHVLLS DSYVSLFAQG
710 720 730 740 750
LIIEYQMGLE VHEKFKEADE DVKILTSSKH LQMCYRFAVS ILLYFYASLF
760 770 780 790 800
GTGHWVGGFT YLANSARLFL PDSSSGLVPL LVLIHLLIPS IVIMASVVAL
810 820 830 840 850
SSFGRQQIRT IFSSLMLICN AVVLFFVVFV PHNAYWPMAH PSVVHALLAQ
860 870 880 890
LTVILILACE SIVTIFFRRL NMNRCSDWRQ EADEFESSYP PITTTAV
Length:897
Mass (Da):101,408
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4771CAAEC0402A92
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54657.2

NCBI Reference Sequences

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RefSeqi
NP_650087.2, NM_141830.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082460; FBpp0081936; FBgn0037915

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6790

UCSC genome browser

More...
UCSCi
CG6790-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54657.2
RefSeqiNP_650087.2, NM_141830.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VGM0, 1 interactor
STRINGi7227.FBpp0081936

Proteomic databases

PaxDbiQ9VGM0
PRIDEiQ9VGM0

Genome annotation databases

EnsemblMetazoaiFBtr0082460; FBpp0081936; FBgn0037915
GeneIDi41388
KEGGidme:Dmel_CG6790
UCSCiCG6790-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0037915 CG6790

Phylogenomic databases

eggNOGiKOG2124 Eukaryota
COG1524 LUCA
GeneTreeiENSGT00390000017600
InParanoidiQ9VGM0
OMAiMKVSREY
OrthoDBi270107at2759
PhylomeDBiQ9VGM0

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41388

Gene expression databases

BgeeiFBgn0037915 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiQ9VGM0 DM

Family and domain databases

CDDicd16020 GPI_EPT_1, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR007070 GPI_EtnP_transferase_1
IPR017852 GPI_EtnP_transferase_1_C
IPR037671 PIGN_N
PANTHERiPTHR12250 PTHR12250, 2 hits
PfamiView protein in Pfam
PF04987 PigN, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VGM0_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VGM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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