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Entry version 140 (18 Sep 2019)
Sequence version 2 (01 Mar 2001)
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Protein

Protein Fer3

Gene

fer3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Fer3
Alternative name(s):
Basic helix-loop-helix protein N-twist
Nephew of atonal 3
Neuronal twist
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fer3
Synonyms:Nato3, Ntwist
ORF Names:CG6913
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037937 Fer3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003286811 – 195Protein Fer3Add BLAST195

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VGJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q9VGJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in 6 to 9 hour old embryos. Expression is highest in 9 to 15 hour old embryos. First detected in stage 11 embryos within the neurogenic region. Detected in the procephalic region, the ventral nerve cord, subesophagal, thoracic and abdominal ganglia in stage 13 to 14 embryos. Detected in embryonic midgut primordia. Barely detectable at the first stage of larval development. Not detectable in older larvae, pupae or adults.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037937 Expressed in 11 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VGJ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VGJ5 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66537, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VGJ5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081911

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9VGJ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 138bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 30Poly-Pro4
Compositional biasi71 – 75Poly-Ser5

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISUY Eukaryota
ENOG4111V63 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000175846

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VGJ5

KEGG Orthology (KO)

More...
KOi
K22400

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDFASPY

Database of Orthologous Groups

More...
OrthoDBi
1513995at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VGJ5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VGJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHPHPIDQP TYMPDVPFQP LWGQEAPPPP IVPYQELIAG FPCTDLSLWQ
60 70 80 90 100
RSQVTPLVPQ RPSTNGRANG SSSSSKKTRR RVASMAQRRA ANIRERRRMF
110 120 130 140 150
NLNEAFDKLR RKVPTFAYEK RLSRIETLRL AITYIGFMAE LLSGTPSNSH
160 170 180 190
KSRSDVYGSM NGHHQAPPPA IHPHHLHPAA AYQRDFASPY NHSLS
Length:195
Mass (Da):22,124
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3AC33803B9D71B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7I → S in CAL26880 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26879 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26878 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26877 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26876 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26875 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26874 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26873 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26872 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26871 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26870 (PubMed:16951084).Curated1
Sequence conflicti7I → S in CAL26869 (PubMed:16951084).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF369898 Genomic DNA Translation: AAK72957.1
AF517123 mRNA Translation: AAN04087.1
AM294883 Genomic DNA Translation: CAL26869.1
AM294884 Genomic DNA Translation: CAL26870.1
AM294885 Genomic DNA Translation: CAL26871.1
AM294886 Genomic DNA Translation: CAL26872.1
AM294887 Genomic DNA Translation: CAL26873.1
AM294888 Genomic DNA Translation: CAL26874.1
AM294889 Genomic DNA Translation: CAL26875.1
AM294890 Genomic DNA Translation: CAL26876.1
AM294891 Genomic DNA Translation: CAL26877.1
AM294892 Genomic DNA Translation: CAL26878.1
AM294893 Genomic DNA Translation: CAL26879.1
AM294894 Genomic DNA Translation: CAL26880.1
AE014297 Genomic DNA Translation: AAF54684.2
AY094777 mRNA Translation: AAM11130.1

NCBI Reference Sequences

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RefSeqi
NP_524322.1, NM_079598.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082435; FBpp0081911; FBgn0037937

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6913

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369898 Genomic DNA Translation: AAK72957.1
AF517123 mRNA Translation: AAN04087.1
AM294883 Genomic DNA Translation: CAL26869.1
AM294884 Genomic DNA Translation: CAL26870.1
AM294885 Genomic DNA Translation: CAL26871.1
AM294886 Genomic DNA Translation: CAL26872.1
AM294887 Genomic DNA Translation: CAL26873.1
AM294888 Genomic DNA Translation: CAL26874.1
AM294889 Genomic DNA Translation: CAL26875.1
AM294890 Genomic DNA Translation: CAL26876.1
AM294891 Genomic DNA Translation: CAL26877.1
AM294892 Genomic DNA Translation: CAL26878.1
AM294893 Genomic DNA Translation: CAL26879.1
AM294894 Genomic DNA Translation: CAL26880.1
AE014297 Genomic DNA Translation: AAF54684.2
AY094777 mRNA Translation: AAM11130.1
RefSeqiNP_524322.1, NM_079598.3

3D structure databases

SMRiQ9VGJ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi66537, 4 interactors
IntActiQ9VGJ5, 2 interactors
STRINGi7227.FBpp0081911

Proteomic databases

PaxDbiQ9VGJ5
PRIDEiQ9VGJ5

Genome annotation databases

EnsemblMetazoaiFBtr0082435; FBpp0081911; FBgn0037937
GeneIDi41411
KEGGidme:Dmel_CG6913

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41411
FlyBaseiFBgn0037937 Fer3

Phylogenomic databases

eggNOGiENOG410ISUY Eukaryota
ENOG4111V63 LUCA
GeneTreeiENSGT00940000175846
InParanoidiQ9VGJ5
KOiK22400
OMAiRDFASPY
OrthoDBi1513995at2759
PhylomeDBiQ9VGJ5

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41411

Protein Ontology

More...
PROi
PR:Q9VGJ5

Gene expression databases

BgeeiFBgn0037937 Expressed in 11 organ(s), highest expression level in embryo
ExpressionAtlasiQ9VGJ5 baseline and differential
GenevisibleiQ9VGJ5 DM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFER3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VGJ5
Secondary accession number(s): A0AQE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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