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Entry version 162 (26 Feb 2020)
Sequence version 1 (01 May 2000)
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Protein

Bloom syndrome protein homolog

Gene

Blm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).By similarity
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei8783' overhang DNA-bindingBy similarity1
Sitei9903' overhang DNA-binding; via amide nitrogenBy similarity1
Sitei10153' overhang DNA-bindingBy similarity1
Sitei10373' overhang DNA-bindingBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1051ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1105ZincBy similarity1
Metal bindingi1123ZincBy similarity1
Metal bindingi1131ZincBy similarity1
Metal bindingi1134ZincBy similarity1
Sitei11673' overhang DNA-bindingBy similarity1
Binding sitei1313ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi738 – 742ATPBy similarity5
Nucleotide bindingi762 – 766ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair, DNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-5693607 Processing of DNA double-strand break ends
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-69473 G2/M DNA damage checkpoint

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bloom syndrome protein homolog (EC:3.6.4.12By similarity)
Short name:
Dmblm
Alternative name(s):
Bloom syndrome helicase ortholog
Mutagen-sensitive protein 309
RecQ helicase homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Blm
Synonyms:mus309
ORF Names:CG6920
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002906 Blm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002050441 – 1487Bloom syndrome protein homologAdd BLAST1487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52Phosphoserine1 Publication1
Modified residuei53Phosphoserine1 Publication1
Modified residuei92Phosphoserine1 Publication1
Modified residuei94Phosphoserine1 Publication1
Modified residuei108Phosphoserine1 Publication1
Modified residuei113Phosphothreonine1 Publication1
Modified residuei118Phosphoserine1 Publication1
Modified residuei120Phosphoserine1 Publication1
Modified residuei130Phosphoserine1 Publication1
Modified residuei151Phosphoserine1 Publication1
Modified residuei153Phosphoserine1 Publication1
Modified residuei180Phosphoserine1 Publication1
Modified residuei182Phosphoserine1 Publication1
Modified residuei197Phosphoserine1 Publication1
Modified residuei203Phosphoserine1 Publication1
Modified residuei328Phosphoserine1 Publication1
Modified residuei506Phosphoserine1 Publication1
Modified residuei509Phosphoserine1 Publication1
Modified residuei510Phosphoserine1 Publication1
Modified residuei535Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VGI8

PRoteomics IDEntifications database

More...
PRIDEi
Q9VGI8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VGI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002906 Expressed in testis and 9 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VGI8 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer (via N-terminus). Homotetramer (via N-terminus); dimer of dimers. Homohexamer (via N-terminus). Self-association negatively regulates DNA unwinding amplitude and rate. Oligomer forms dissociate into monomer in presence of ATP.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66499, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-23386N

Protein interaction database and analysis system

More...
IntActi
Q9VGI8, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9VGI8

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081910

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VGI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati89 – 11211 PublicationAdd BLAST24
Repeati115 – 13821 PublicationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini746 – 921Helicase ATP-bindingPROSITE-ProRule annotationBy similarityAdd BLAST176
Domaini944 – 1093Helicase C-terminalPROSITE-ProRule annotationBy similarityAdd BLAST150
Domaini1283 – 1363HRDCPROSITE-ProRule annotationBy similarityAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 1382 X 24 AA repeats of L-D-L-S-V-S-P-L-A-E-L-[SP]-A-K-K-K-[YS]-[AD]-R-D-[SP]-P-P-K-PAdd BLAST50
Regioni967 – 9693' overhang DNA-bindingBy similarity3
Regioni1069 – 10723' overhang DNA-bindingBy similarity4
Regioni1167 – 11693' overhang DNA-bindingBy similarity3
Regioni1178 – 11823' overhang DNA-bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi865 – 868DEAH box4
Motifi1416 – 1432Nuclear localization signalBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 230Poly-Pro6
Compositional biasi464 – 467Poly-Ser4
Compositional biasi1369 – 1372Poly-Glu4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0351 Eukaryota
COG0514 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004162_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VGI8

KEGG Orthology (KO)

More...
KOi
K10901

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIVGYCE

Database of Orthologous Groups

More...
OrthoDBi
445763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VGI8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00614 recQ_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VGI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKPVAQRK QLTLSSFIGL DGNSQSQPKS RAASVRSKPP AVYNPIFLDA
60 70 80 90 100
SSSDDETTEI SSQSNNGTIA TKKSSRDPRT AKLKKHTYLD LSVSPLAKLS
110 120 130 140 150
AKKYARDSPK KPTSLDLSVS PLAELLAKKS DRDSPKKPVQ NENSYTYRGL
160 170 180 190 200
SESPVENKSI GDTLRKPPQK ERKTSIVWLS DSPEKKVTQN ERKILDSPLQ
210 220 230 240 250
RFSFEDFPNK ENGNRHHLLT LPDSPPPPQP VKKPEKTMWQ NETKTIQDKD
260 270 280 290 300
SPANPLVSNN LASISTLLDS SRAPNTYKGS SRNLFEDSPE KSGSGEQGYK
310 320 330 340 350
LGSAKENEIP TKPATASLER NSVTSSPSPA APLKPRYSVA FDNSLADYLK
360 370 380 390 400
DLAQNDNFSI DPNKQNTETL KSTLGFFRNT YVELMEKYCS LIDQIPAMHF
410 420 430 440 450
NEIAGFQPNT FLKLKVMRQK FKARTQLVQN SLDKKESQLK AEQEALEKEE
460 470 480 490 500
IEMQAEQAQQ TVLSSSSPEK SRPIMPLPKV QEIKDEKIPN RNQLIHDLCG
510 520 530 540 550
EPDNFSPPSS PRDTQLIPKR QQLINDLCGE PDDFSPPSKQ NDPHLLRKCE
560 570 580 590 600
ELVHDLCEEP DDYLAQSMML DGDLEEEQLN GPTQGTTTSG MDDDEDDLEG
610 620 630 640 650
LLAEIEDEHQ KMQGRRSEFN GYSYKELEAV KVKEKHKETP INISLDDDGF
660 670 680 690 700
PEYDEAMFEQ MHSQAAANKS RVSSAGPSTS KSVVPTKQTS ALHSQKLSGN
710 720 730 740 750
FHANVHNDGI TGEFDGQKFE HSTRLMHGLS YSFGLKSFRP NQLQVINATL
760 770 780 790 800
LGNDCFVLMP TGGGKSLCYQ LPAILTEGVT IVISPLKSLI FDQINKLASL
810 820 830 840 850
DICAKSLSGE QKMADVMAIY RDLESQPPMV KLLYVTPEKI SSSARFQDTL
860 870 880 890 900
DTLNSNNYIS RFVIDEAHCV SQWGHDFRPD YKKLGVLKKR FPNVPTIALT
910 920 930 940 950
ATATPRVRLD ILAQLNLKNC KWFLSSFNRS NLRYRVLPKK GVSTLDDISR
960 970 980 990 1000
YIRSKPQHFS GIIYCLSRKE CDETSKKMCK DGVRAVSYHA GLTDTDRESR
1010 1020 1030 1040 1050
QKDWLTGKMR VICATVAFGM GIDKPDVRFV LHYSLPKSIE GYYQEAGRAG
1060 1070 1080 1090 1100
RDGDVADCIL YYNYSDMLRI KKMLDSDKAL QYNVKKIHVD NLYRIVGYCE
1110 1120 1130 1140 1150
NLTDCRRAQQ LDYFGEHFTS EQCLENRETA CDNCINKRAY KAVDALEHAR
1160 1170 1180 1190 1200
KAARAVKDLC SGRSRFTLLH IADVLKGSKI KKIIDFNHHK TPHHGVLKDW
1210 1220 1230 1240 1250
DKNDVHRLLR KMVIDGFLRE DLIFTNDFPQ AYLYLGNNIS KLMEGTPNFE
1260 1270 1280 1290 1300
FAVTKNAKEA KAAVGSVSDG ATSSTADGQS GMREIHERCY TDLLDLCRTI
1310 1320 1330 1340 1350
ASQRNVTMAS IMNIQALKSM AETLPITEKD MCSIPHVTKA NFDKYGAKLL
1360 1370 1380 1390 1400
EITSNYASEK LLMQAVLDEE EEQAAAKQRP STSGWNNESV DWDMAVASQG
1410 1420 1430 1440 1450
NANTSGASGF NSFRAGKRKK IYKSGASKRY KTSTTSPAAR KTTSARGRGG
1460 1470 1480
RAGAKRAESS ASSASGWKSK KTGNSFGFDL MPLPGSK
Length:1,487
Mass (Da):166,079
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07361B8005E29432
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98K → E in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti110K → P in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti126L → P in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti134 – 136SPK → PPP in AAD41441 (PubMed:10049920).Curated3
Sequence conflicti169Q → P in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti222P → S in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti299Y → N in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti417M → V in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti459Q → R in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti471S → C in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti496H → P in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti594D → G in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti614G → A in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti805K → E in AAD41441 (PubMed:10049920).Curated1
Sequence conflicti1116E → G in AAD41441 (PubMed:10049920).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U92536 mRNA Translation: AAD41441.1
AE014297 Genomic DNA Translation: AAF54691.1

NCBI Reference Sequences

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RefSeqi
NP_524319.2, NM_079595.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0082434; FBpp0081910; FBgn0002906

Database of genes from NCBI RefSeq genomes

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GeneIDi
41366

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6920

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92536 mRNA Translation: AAD41441.1
AE014297 Genomic DNA Translation: AAF54691.1
RefSeqiNP_524319.2, NM_079595.3

3D structure databases

SMRiQ9VGI8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi66499, 20 interactors
DIPiDIP-23386N
IntActiQ9VGI8, 7 interactors
MINTiQ9VGI8
STRINGi7227.FBpp0081910

PTM databases

iPTMnetiQ9VGI8

Proteomic databases

PaxDbiQ9VGI8
PRIDEiQ9VGI8

Genome annotation databases

EnsemblMetazoaiFBtr0082434; FBpp0081910; FBgn0002906
GeneIDi41366
KEGGidme:Dmel_CG6920

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
641
FlyBaseiFBgn0002906 Blm

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00940000156800
HOGENOMiCLU_004162_0_0_1
InParanoidiQ9VGI8
KOiK10901
OMAiRIVGYCE
OrthoDBi445763at2759
PhylomeDBiQ9VGI8

Enzyme and pathway databases

ReactomeiR-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-5693607 Processing of DNA double-strand break ends
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-69473 G2/M DNA damage checkpoint

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41366

Protein Ontology

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PROi
PR:Q9VGI8

Gene expression databases

BgeeiFBgn0002906 Expressed in testis and 9 other tissues
GenevisibleiQ9VGI8 DM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit
SUPFAMiSSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBLM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VGI8
Secondary accession number(s): Q9Y062
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: February 26, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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