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Protein

Glutathione S-transferase D6

Gene

GstD6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Kineticsi

  1. KM=1.23 mM for glutathione1 Publication
  2. KM=3.79 mM for 1-chloro-2,4-dinitrobenzene1 Publication
  1. Vmax=0.07 µmol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate1 Publication
  2. Vmax=0.013 µmol/min/mg enzyme with phenethyl isothiocyanate as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: FlyBase

GO - Biological processi

  • glutathione metabolic process Source: FlyBase
  • response to toxic substance Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase D61 Publication (EC:2.5.1.181 Publication)
Gene namesi
Name:GstD6Imported
Synonyms:gstD25, GSTD6-6Imported
ORF Names:CG4423Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010042 GstD6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859581 – 215Glutathione S-transferase D6Add BLAST215

Proteomic databases

PaxDbiQ9VG94
PRIDEiQ9VG94

Expressioni

Gene expression databases

BgeeiFBgn0010042
ExpressionAtlasiQ9VG94 baseline and differential
GenevisibleiQ9VG94 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GstD4Q9VG963EBI-152218,EBI-117276

Protein-protein interaction databases

BioGridi71336, 2 interactors
DIPiDIP-19904N
IntActiQ9VG94, 2 interactors
STRINGi7227.FBpp0082045

Structurei

3D structure databases

ProteinModelPortaliQ9VG94
SMRiQ9VG94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80GST N-terminalAdd BLAST80
Domaini86 – 206GST C-terminalAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 52Glutathione bindingBy similarity3
Regioni64 – 66Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Delta family.1 Publication

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
InParanoidiQ9VG94
KOiK00799
OMAiIWETRAI
OrthoDBiEOG091G0MS3
PhylomeDBiQ9VG94

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VG94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLYNMSGSP STRAVMMTAK AVGVEFNSIQ VNTFVGEQLE PWFVKINPQH
60 70 80 90 100
TIPTLVDNLF VIWETRAIVV YLVEQYGKDD SLYPKDPQKQ ALINQRLYFD
110 120 130 140 150
MGTLYDGIAK YFFPLLRTGK PGTQENLEKL NAAFDLLNNF LDGQDYVAGN
160 170 180 190 200
QLSVADIVIL ATVSTTEMVD FDLKKFPNVD RWYKNAQKVT PGWDENLARI
210
QSAKKFLAEN LIEKL
Length:215
Mass (Da):24,485
Last modified:May 1, 2000 - v1
Checksum:i6195738AD6E20D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97702 Genomic DNA No translation available.
AE014297 Genomic DNA Translation: AAF54791.1
PIRiB46681
RefSeqiNP_524915.1, NM_080176.3

Genome annotation databases

EnsemblMetazoaiFBtr0082573; FBpp0082045; FBgn0010042
GeneIDi48339
KEGGidme:Dmel_CG4423

Similar proteinsi

Entry informationi

Entry nameiGSTD6_DROME
AccessioniPrimary (citable) accession number: Q9VG94
Secondary accession number(s): Q9TX93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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