AT27578p

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA helicase activity Source: FlyBase
• mRNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA helicase activity Source: FlyBase

GO - Biological processⁱ

• compound eye photoreceptor fate commitment Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling."
    Pazman C., Mayes C.A., Fanto M., Haynes S.R., Mlodzik M.
    Development 127:1715-1725(2000) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Rasputin functions as a positive regulator of orb in Drosophila oogenesis."
    Costa A., Pazman C., Sinsimer K.S., Wong L.C., McLeod I., Yates J., Haynes S., Schedl P.
    PLoS One 8:e72864-e72864(2013) [PubMed] [Europe PMC] [Abstract]
• ommatidial rotation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling."
    Pazman C., Mayes C.A., Fanto M., Haynes S.R., Mlodzik M.
    Development 127:1715-1725(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Rasputin functions as a positive regulator of orb in Drosophila oogenesis."
    Costa A., Pazman C., Sinsimer K.S., Wong L.C., McLeod I., Yates J., Haynes S., Schedl P.
    PLoS One 8:e72864-e72864(2013) [PubMed] [Europe PMC] [Abstract]
• response to amino acid starvation Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation."
    Aguilera-Gomez A., Zacharogianni M., van Oorschot M.M., Genau H., Grond R., Veenendaal T., Sinsimer K.S., Gavis E.R., Behrends C., Rabouille C.
    Cell Rep 20:935-948(2017) [PubMed] [Europe PMC] [Abstract]
• stress granule assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation."
    Aguilera-Gomez A., Zacharogianni M., van Oorschot M.M., Genau H., Grond R., Veenendaal T., Sinsimer K.S., Gavis E.R., Behrends C., Rabouille C.
    Cell Rep 20:935-948(2017) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVMDATQSQQ PSPQSVGREF VRQYYTLLNK APNHLHRFYN HNSSYIHGES 
        60         70         80         90        100
KLVVGQREIH NRIQQLNFND CHAKISQVDA QATLGNGVVV QVTGELSNDG 
       110        120        130        140        150
QPMRRFTQTF VLAAQSPKKY YVHNDIFRYQ DLYIEDEQDG ESRSENDEEH 
       160        170        180        190        200
DVQVVGGTVD QAVQVAGDVV AQQPQQQQAP PQPQAQVVVP QQVAPVAAGG 
       210        220        230        240        250
AAPQQIFYPL PAGAAAGRPV AVLPPAPQAA AVPLPAQFTV PPPQPIQNGV 
       260        270        280        290        300
VSHEELQQQQ VLVPPSVSPL VQQQQPTGTP VLPIVPVPSA GFQQSPLVAP 
       310        320        330        340        350
QLIQQQQQQQ PAQLPPQQQQ QQQPIQQQQP LQQQQQPLAE PEEVEVAPRQ 
       360        370        380        390        400
QKPPTPVEDF KTIHEQQQQE KYEAAKQQQN EPKTYANLFK STSSSPSGFV 
       410        420        430        440        450
NAALQQQQQL QQQQQQQQSI SSNTYNSSSA TSGGGNGSQV SYSTTASSYN 
       460        470        480        490        500
NSNGNSRLDN GGPLPQRNNS IRNNKGDFEQ RRSSNTQQFG DNQQLFLGNI 
       510        520        530        540        550
PHHASEDDLR EIFSRFGNVL ELRILSKAGN KVPPGMRSPL NYGFITYDDP 
       560        570        580        590        600
EAVQKCLANC PLYFPENSPD GQKLNVEEKK PRVRNDMVPR QQIGGNNLNN 
       610        620        630        640        650
NMGRLGGNNG PQSRPMGNNN GSGGGMMRNN AGGNNLRQGG GGGNGAPRLG 
       660        670        680        690
GGGGFGQRQD NRTGGGNNQS NGPLRGAGNG QSGGGNYGRR            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ