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Protein

26S proteasome non-ATPase regulatory subunit 9

Gene

CG9588

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 9By similarity
Alternative name(s):
26S proteasome regulatory subunit p27By similarity
Short name:
dp271 Publication
Gene namesi
ORF Names:CG9588
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038166 CG9588

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi9E → A: Abolishes interaction with PI31. 1 Publication1
Mutagenesisi10R → A: Does not affect interaction with PI31. 1 Publication1
Mutagenesisi11L → A: Does not affect interaction with PI31. 1 Publication1
Mutagenesisi114P → A: Does not affect interaction with PI31. 1 Publication1
Mutagenesisi121D → A: Does not affect interaction with PI31. 1 Publication1
Mutagenesisi185V → T: Does not affect interaction with PI31. 1 Publication1
Mutagenesisi187R → A: Abolishes interaction with PI31. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004248931 – 22026S proteasome non-ATPase regulatory subunit 9Add BLAST220

Proteomic databases

PaxDbiQ9VFS8
PRIDEiQ9VFS8

Expressioni

Gene expression databases

BgeeiFBgn0038166
GenevisibleiQ9VFS8 DM

Interactioni

Subunit structurei

Interacts with PI31; this interaction is increased by PI31 ADP-ribosylation. Interacts with Rpt5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PI31Q9V6373EBI-166054,EBI-144377

Protein-protein interaction databases

BioGridi66752, 14 interactors
IntActiQ9VFS8, 20 interactors
STRINGi7227.FBpp0082314

Structurei

3D structure databases

ProteinModelPortaliQ9VFS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 200PDZSequence analysisAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 32Sequence analysisAdd BLAST29
Coiled coili61 – 91Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the proteasome subunit p27 family.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3129 Eukaryota
COG0265 LUCA
GeneTreeiENSGT00390000004147
InParanoidiQ9VFS8
KOiK06693
OMAiLGCNIVP
OrthoDBiEOG091G0N53
PhylomeDBiQ9VFS8

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035269 PSMD9
PANTHERiPTHR12651 PTHR12651, 1 hit
PfamiView protein in Pfam
PF13180 PDZ_2, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VFS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGTTTKER LERLINAKKQ LEAQINRNGQ ILAANDNVGM SGPLVDAEGF
60 70 80 90 100
PRNDIDVYQV RLARQTIICL QNDHKELMNQ IQTLLNQYHS EIATTDPELV
110 120 130 140 150
NRASALDLDS DRSPGGANIT DLAPARAIVV VNLVSPDSPA ERAGLCAGDA
160 170 180 190 200
ILRFGSINSG NFKGDLAQIG ELVRNMQSQN VQLKVKRGEQ QLDLILVPKT
210 220
WSGRGLLGCN IVLPPEAMDH
Length:220
Mass (Da):23,898
Last modified:May 1, 2000 - v1
Checksum:iC618E8D04262293A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54971.1
AY071064 mRNA Translation: AAL48686.1
RefSeqiNP_650301.1, NM_142044.4
UniGeneiDm.20184

Genome annotation databases

EnsemblMetazoaiFBtr0082849; FBpp0082314; FBgn0038166
GeneIDi41672
KEGGidme:Dmel_CG9588
UCSCiCG9588-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPSMD9_DROME
AccessioniPrimary (citable) accession number: Q9VFS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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