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UniProtKB - Q9VFP1 (CP6D5_DROME)
Protein
Probable cytochrome P450 6d5
Gene
Cyp6d5
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 453 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp6d5 ORF Names:CG3050 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0038194, Cyp6d5 |
VEuPathDBi | VectorBase:FBgn0038194 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051882 | 1 – 508 | Probable cytochrome P450 6d5Add BLAST | 508 |
Proteomic databases
PaxDbi | Q9VFP1 |
PRIDEi | Q9VFP1 |
Expressioni
Gene expression databases
Bgeei | FBgn0038194, Expressed in thoracico-abdominal ganglion (Drosophila) and 44 other tissues |
Genevisiblei | Q9VFP1, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 66783, 3 interactors |
DIPi | DIP-20369N |
IntActi | Q9VFP1, 2 interactors |
STRINGi | 7227.FBpp0088707 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000168877 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9VFP1 |
OMAi | GMHRDEE |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9VFP1 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VFP1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIGIYLLIAA VTLLYVYLKW TFSYWDRKGF PSTGVSIPFG ALESVTKGKR
60 70 80 90 100
SFGMAIYDMY KSTKEPVIGL YLTLRPALLV RDAQLAHDVL VKDFASFHDR
110 120 130 140 150
GVYVDEKNDP MSASLFQMEG ASWRALRNKL TPSFTSGKLK AMFETSDSVG
160 170 180 190 200
DKLVDSIRKQ LPANGAKELE LKKLMATYAI DIIATTIFGL DVDSFADPNN
210 220 230 240 250
EFQIISKKVN RNNIEDIIRG TSSFLYPGLE KFFVKIGWKQ EATERMRELS
260 270 280 290 300
NRTVDLREQN NIVRKDLLQL LLQLRNQGKI NTDDNIWSAE STKNGVKSMS
310 320 330 340 350
KDLIAGQLFL FYVAGYETTA STTSFTLYEL TQNPEVMEKA KEDVRSAIEK
360 370 380 390 400
HGGKLTYDAI SDMKYLEACI LETARKYPAL PLLNRICTKD YPVPDSKLVI
410 420 430 440 450
QKGTPIIISL IGMHRDEEYF PDPLAYKPER YLENGKDYTQ AAYLPFGEGP
460 470 480 490 500
RMCIGARMGK VNVKIAIAKV LSNFDLEIRK EKCEIEFGVY GIPLMPKSGV
PVRLSLKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55009.1 AY118299 mRNA Translation: AAM48328.1 |
RefSeqi | NP_650327.1, NM_142070.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0089766; FBpp0088707; FBgn0038194 |
GeneIDi | 41706 |
KEGGi | dme:Dmel_CG3050 |
UCSCi | CG3050-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55009.1 AY118299 mRNA Translation: AAM48328.1 |
RefSeqi | NP_650327.1, NM_142070.3 |
3D structure databases
AlphaFoldDBi | Q9VFP1 |
SMRi | Q9VFP1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 66783, 3 interactors |
DIPi | DIP-20369N |
IntActi | Q9VFP1, 2 interactors |
STRINGi | 7227.FBpp0088707 |
Proteomic databases
PaxDbi | Q9VFP1 |
PRIDEi | Q9VFP1 |
Protocols and materials databases
DNASUi | 41706 |
Genome annotation databases
EnsemblMetazoai | FBtr0089766; FBpp0088707; FBgn0038194 |
GeneIDi | 41706 |
KEGGi | dme:Dmel_CG3050 |
UCSCi | CG3050-RA, d. melanogaster |
Organism-specific databases
CTDi | 41706 |
FlyBasei | FBgn0038194, Cyp6d5 |
VEuPathDBi | VectorBase:FBgn0038194 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000168877 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9VFP1 |
OMAi | GMHRDEE |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9VFP1 |
Miscellaneous databases
BioGRID-ORCSi | 41706, 0 hits in 3 CRISPR screens |
GenomeRNAii | 41706 |
PROi | PR:Q9VFP1 |
Gene expression databases
Bgeei | FBgn0038194, Expressed in thoracico-abdominal ganglion (Drosophila) and 44 other tissues |
Genevisiblei | Q9VFP1, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP6D5_DROME | |
Accessioni | Q9VFP1Primary (citable) accession number: Q9VFP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families