UniProtKB - Q9VFC0 (SCC4_DROME)
Protein
MAU2 chromatid cohesion factor homolog
Gene
Mau2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).By similarity
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
GO - Biological processi
- axon guidance Source: FlyBase
- cell division Source: UniProtKB-KW
- maintenance of mitotic sister chromatid cohesion Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis |
Enzyme and pathway databases
Reactomei | R-DME-2470946, Cohesin Loading onto Chromatin |
Names & Taxonomyi
Protein namesi | Recommended name: MAU2 chromatid cohesion factor homologBy similarityAlternative name(s): Cohesin loading complex subunit SCC4 homologBy similarity Mau2 sister chromatid cohesion factorImported |
Gene namesi | Name:Mau2Imported ORF Names:CG4203Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0038300, Mau2 |
Subcellular locationi
Nucleus
- nucleoplasm By similarity
Note: Binds to chromatin from the end of mitosis until prophase.By similarity
Nucleus
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
- SMC loading complex Source: UniProtKB
Other locations
- chromatin Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000382732 | 1 – 632 | MAU2 chromatid cohesion factor homologAdd BLAST | 632 |
Proteomic databases
PaxDbi | Q9VFC0 |
PRIDEi | Q9VFC0 |
Expressioni
Gene expression databases
Bgeei | FBgn0038300, Expressed in embryo and 18 other tissues |
Genevisiblei | Q9VFC0, DM |
Interactioni
Subunit structurei
Interacts with Nipped-B to form the cohesin loading complex.
By similarityProtein-protein interaction databases
BioGRIDi | 66894, 2 interactors |
DIPi | DIP-29197N |
IntActi | Q9VFC0, 2 interactors |
STRINGi | 7227.FBpp0082507 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 453 – 486 | TPR 1Add BLAST | 34 | |
Repeati | 493 – 526 | TPR 2Add BLAST | 34 |
Sequence similaritiesi
Belongs to the SCC4/mau-2 family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG2300, Eukaryota |
GeneTreei | ENSGT00390000012198 |
HOGENOMi | CLU_030238_0_0_1 |
InParanoidi | Q9VFC0 |
OMAi | APNWPSD |
OrthoDBi | 240898at2759 |
PhylomeDBi | Q9VFC0 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR019440, MAU2 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR21394, PTHR21394, 1 hit |
Pfami | View protein in Pfam PF10345, Cohesin_load, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VFC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSASTSTSTA ASQDACYISL LGLAEYFRTS QPPNIKKCIQ CLQALFTFMP
60 70 80 90 100
PSKVEARTHL QMGQILMAYT KNIDLARQHL EKAWSISEPL PNFDVKFDTA
110 120 130 140 150
SLLAQLHLQT DRNSHQAKAM LRRAVELSQN NVYWHCKLLL QLAQIHASDR
160 170 180 190 200
EYSLASELLA VGAESADEAS ATYLKVLFLL SRAMILMIER KTNDVLALLN
210 220 230 240 250
SAGQIIDNNI PNPHQKEYLK VFFLVLQVCY YLALGQVKTV KPSLKQLQMS
260 270 280 290 300
IQTIMAPNWP SDEAIFGANQ LEMFVWLPKE QLYVLVYLVT VSHSMMAGYM
310 320 330 340 350
DKAQKYTEKA LTQIEKLKQQ EDKPILSVFK VILLEHIVMC RMVMGNRELA
360 370 380 390 400
IREIAAARDV CMAAPQRSLL RRHSAQLHCL IGLYSMSTNL FEHAERQFVV
410 420 430 440 450
CVSETSERDL KLFANLNLAI IYLRTKRDTD LKQILDAVST ENTHTYSSQA
460 470 480 490 500
LMGGFYYVQG LHAFHKNSFH EAKRFLRETL KMANAEDLNR LTSCSLVLLS
510 520 530 540 550
HVFLSIGNSK ESMNMVTPAM QLASKIPDIH VQLWGSAILK DLHRMSKDVQ
560 570 580 590 600
HEKDAYANHV KYSENLIADQ RKCVQSAHHE LVNWFQGDPP VTSGPPAAPV
610 620 630
LLMPESSVTA SVPVIASTST AMQPAGQYGQ FY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55140.1 AY069560 mRNA Translation: AAL39705.1 |
RefSeqi | NP_650428.1, NM_142171.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0083048; FBpp0082507; FBgn0038300 |
GeneIDi | 41830 |
KEGGi | dme:Dmel_CG4203 |
UCSCi | CG4203-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55140.1 AY069560 mRNA Translation: AAL39705.1 |
RefSeqi | NP_650428.1, NM_142171.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 66894, 2 interactors |
DIPi | DIP-29197N |
IntActi | Q9VFC0, 2 interactors |
STRINGi | 7227.FBpp0082507 |
Proteomic databases
PaxDbi | Q9VFC0 |
PRIDEi | Q9VFC0 |
Genome annotation databases
EnsemblMetazoai | FBtr0083048; FBpp0082507; FBgn0038300 |
GeneIDi | 41830 |
KEGGi | dme:Dmel_CG4203 |
UCSCi | CG4203-RA, d. melanogaster |
Organism-specific databases
CTDi | 23383 |
FlyBasei | FBgn0038300, Mau2 |
Phylogenomic databases
eggNOGi | KOG2300, Eukaryota |
GeneTreei | ENSGT00390000012198 |
HOGENOMi | CLU_030238_0_0_1 |
InParanoidi | Q9VFC0 |
OMAi | APNWPSD |
OrthoDBi | 240898at2759 |
PhylomeDBi | Q9VFC0 |
Enzyme and pathway databases
Reactomei | R-DME-2470946, Cohesin Loading onto Chromatin |
Miscellaneous databases
BioGRID-ORCSi | 41830, 0 hits in 1 CRISPR screen |
GenomeRNAii | 41830 |
PROi | PR:Q9VFC0 |
Gene expression databases
Bgeei | FBgn0038300, Expressed in embryo and 18 other tissues |
Genevisiblei | Q9VFC0, DM |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR019440, MAU2 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR21394, PTHR21394, 1 hit |
Pfami | View protein in Pfam PF10345, Cohesin_load, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCC4_DROME | |
Accessioni | Q9VFC0Primary (citable) accession number: Q9VFC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families