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Entry version 165 (29 Sep 2021)
Sequence version 2 (01 Mar 2001)
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Protein

Alpha-mannosidase

Gene

alpha-Man-IIb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotationARBA annotation, Hydrolase
LigandMetal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-975578, Reactions specific to the complex N-glycan synthesis pathway

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH38, Glycoside Hydrolase Family 38

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-mannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alpha-Man-IIbImported
Synonyms:1Imported, alpha-M-IIImported, alpha-Man-II bImported, alpha-Man-IIb-RAImported, dGMIIbImported, DM-GII.2Imported, Dmel\CG4606Imported, GMImported, GTD#24Imported, Man'aseImported, ManIIbImported
ORF Names:CG4606Imported, Dmel_CG4606Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026616, alpha-Man-IIb

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0026616

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 30HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VF33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026616, Expressed in male reproductive gland and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VF33, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VF33, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082633

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini508 – 596Alpha-mann_midInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni81 – 108DisorderedSequence analysisAdd BLAST28
Regioni645 – 669DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1958, Eukaryota
KOG1959, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004690_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRQGYDC

Database of Orthologous Groups

More...
OrthoDBi
1101882at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VF33

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.50, 1 hit
2.60.40.1180, 1 hit
3.20.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR011330, Glyco_hydro/deAcase_b/a-brl
IPR011682, Glyco_hydro_38_C
IPR015341, Glyco_hydro_38_cen
IPR037094, Glyco_hydro_38_cen_sf
IPR000602, Glyco_hydro_38_N
IPR027291, Glyco_hydro_38_N_sf
IPR028995, Glyco_hydro_57/38_cen_sf
IPR013780, Glyco_hydro_b

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09261, Alpha-mann_mid, 1 hit
PF07748, Glyco_hydro_38C, 1 hit
PF01074, Glyco_hydro_38N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00872, Alpha-mann_mid, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74650, SSF74650, 1 hit
SSF88688, SSF88688, 1 hit
SSF88713, SSF88713, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VF33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFKLFRRGS ARCIGLLSAF VTILLCLYYI SIGQPNPTPI SETGAPSAAL
60 70 80 90 100
RGSPLSGLTG FSVDGGSSSI IHQQKQQLVI ASNQKKSSET KSAQTSVSPE
110 120 130 140 150
EQSEEQYTNS NWGDKCYELI QSNTNITASE EHSKFDFQPE WMRSKEYWDR
160 170 180 190 200
GFEERFDAQK KDKQRPPLKI IVVPHSHNDP GWLKTFTNYF QSDSRQILNL
210 220 230 240 250
LVTKMQEYTD MTFIWSEISF LQLWWDQAHP TKQRALKRLI DAGRIEITTG
260 270 280 290 300
GWVMTDEANV HIYPMLDQLI EGHQWLKNNL NVTPKVGWSI DPFGHGSTVP
310 320 330 340 350
YLLSGANFEG TIIQRIHYAW KQWFARQQSG DFIWKPYWRS RKDKDSEAGS
360 370 380 390 400
LLTHNMPFDI YSIKGSCGPH PFICLNFDFR KIPGEYTEYS VKAQFITDDN
410 420 430 440 450
LESKAQLLLE QYARTASLFP HNVALIPVGD DFRYNKDREV DQQYQNYKKL
460 470 480 490 500
IDHIMANRRL YNADIRFGTP SDYFEAIKER MKDHTPGFPT FKGDFFVYSD
510 520 530 540 550
IFSEGRPAYW SGYFTTRPFY KLLSSELEHQ LRSAEIVFTL AYNTARQAKR
560 570 580 590 600
ENAIKIYEKN YELIINARRN LGLFQHHDAI TGTSKAAVMR DYAMRLFEST
610 620 630 640 650
QNMVKMQESC LELLLQKGQP RHHGFLLSEF ERDNFNKLPR KMPIQMANGD
660 670 680 690 700
ESTPTVPAGE GGAGGSSSSG SVGSFVLYNS LAQKRLEVVT LRVQHPNVKI
710 720 730 740 750
VNDKGVELNH IQINPVWNIT DTYEQGLGTS VSGTVGRIRT STRQFEVMFV
760 770 780 790 800
AELEPLSLST YRVQVDEVNF KRNIATIYCD DCTESQPASV SPPEEIESSP
810 820 830 840 850
TSVFEARGKP AGDIQLENPH MRLLFDEKSG FLKTITRKNQ KKELLKPLQC
860 870 880 890 900
NIKFAAYRSA QFHSGAYLFK TDPEQSEAEK EVLEGYTDMR IIITSGPIAS
910 920 930 940 950
DVTVIYGPFL AHTVRIFNTR THLDAAIYVE NDIDFEPPPK NRETELFMRF
960 970 980 990 1000
VTNIDNIAQA PMQRDPLKEP VDAATMPELP VFYSDQNGFQ YHERIKVPAI
1010 1020 1030 1040 1050
GIEGNYFPIT SGAFIQDSRL RLTLLTTHAQ GAASYEPGQL EVMLDRRTLY
1060 1070 1080 1090 1100
DDYRGMGEGV VDSRLTRHKF WLLVEDLPGG QHVTQPPSYK VLSQQAQQLA
1110 1120 1130 1140 1150
NALRYPPNLY FVSNLEQPEL AAALLPLVRL LPKGPLPCDV HLTTLRTLSD
1160 1170 1180 1190 1200
PELQLFPSAS ALLVLHRQGF DCSVSAGREL SMEAICPLSS KGLGNVQLGR
1210 1220 1230 1240
LSLHTIEATS LTGTEQKSSR ESYHIRSLAE ISLEPMELRT FNLTFRSEV
Length:1,249
Mass (Da):141,918
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03F1A3F15300DD3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55228.2
AE014297 Genomic DNA Translation: AGB95994.1
BT150367 mRNA Translation: AGW52177.1
AE014297 Genomic DNA Translation: AHN57340.1

NCBI Reference Sequences

More...
RefSeqi
NP_001262614.1, NM_001275685.1
NP_001287341.1, NM_001300412.1
NP_650494.2, NM_142237.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083179; FBpp0082633; FBgn0026616
FBtr0334593; FBpp0306660; FBgn0026616
FBtr0345238; FBpp0311424; FBgn0026616

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4606

UCSC genome browser

More...
UCSCi
CG4606-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55228.2
AE014297 Genomic DNA Translation: AGB95994.1
BT150367 mRNA Translation: AGW52177.1
AE014297 Genomic DNA Translation: AHN57340.1
RefSeqiNP_001262614.1, NM_001275685.1
NP_001287341.1, NM_001300412.1
NP_650494.2, NM_142237.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VF33, 4 interactors
STRINGi7227.FBpp0082633

Protein family/group databases

CAZyiGH38, Glycoside Hydrolase Family 38

Proteomic databases

PRIDEiQ9VF33

Genome annotation databases

EnsemblMetazoaiFBtr0083179; FBpp0082633; FBgn0026616
FBtr0334593; FBpp0306660; FBgn0026616
FBtr0345238; FBpp0311424; FBgn0026616
GeneIDi41913
KEGGidme:Dmel_CG4606
UCSCiCG4606-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41913
FlyBaseiFBgn0026616, alpha-Man-IIb
VEuPathDBiVectorBase:FBgn0026616

Phylogenomic databases

eggNOGiKOG1958, Eukaryota
KOG1959, Eukaryota
GeneTreeiENSGT01030000234638
HOGENOMiCLU_004690_1_0_1
OMAiHRQGYDC
OrthoDBi1101882at2759
PhylomeDBiQ9VF33

Enzyme and pathway databases

ReactomeiR-DME-975578, Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41913, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
alpha-Man-IIa, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41913

Gene expression databases

BgeeiFBgn0026616, Expressed in male reproductive gland and 18 other tissues
ExpressionAtlasiQ9VF33, baseline and differential

Family and domain databases

Gene3Di1.20.1270.50, 1 hit
2.60.40.1180, 1 hit
3.20.110.10, 1 hit
InterProiView protein in InterPro
IPR011013, Gal_mutarotase_sf_dom
IPR011330, Glyco_hydro/deAcase_b/a-brl
IPR011682, Glyco_hydro_38_C
IPR015341, Glyco_hydro_38_cen
IPR037094, Glyco_hydro_38_cen_sf
IPR000602, Glyco_hydro_38_N
IPR027291, Glyco_hydro_38_N_sf
IPR028995, Glyco_hydro_57/38_cen_sf
IPR013780, Glyco_hydro_b
PfamiView protein in Pfam
PF09261, Alpha-mann_mid, 1 hit
PF07748, Glyco_hydro_38C, 1 hit
PF01074, Glyco_hydro_38N, 1 hit
SMARTiView protein in SMART
SM00872, Alpha-mann_mid, 1 hit
SUPFAMiSSF74650, SSF74650, 1 hit
SSF88688, SSF88688, 1 hit
SSF88713, SSF88713, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VF33_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VF33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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