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Entry version 164 (07 Oct 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Protein mini spindles

Gene

msps

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization. Seems to be involved in elongation of kinetochore-derived microtubule fibers.1 Publication7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mini spindles
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:msps
ORF Names:CG5000Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0027948, msps

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21W → E: Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-292. 2 Publications1
Mutagenesisi292W → E: Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-21. 2 Publications1
Mutagenesisi546 – 549KVLK → EAAE: Disrupts microtubule lattice binding. 1 Publication4
Mutagenesisi606W → E: Impairs microtubule polymerization, decreases microtubule lattice localization. 1 Publication1
Mutagenesisi874W → E: Impairs microtubule polymerization, decreases microtubule lattice localization. 1 Publication1
Mutagenesisi1102 – 1107KLKTVR → ELEAAA: Disrupts microtubule lattice binding. 1 Publication6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004375741 – 2042Protein mini spindlesAdd BLAST2042

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VEZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0027948, Expressed in brain and 46 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VEZ3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tacc, dgt6.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VEZ3, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293341

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12042
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VEZ3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9VEZ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati120 – 157HEAT 1Sequence analysisAdd BLAST38
Repeati160 – 197HEAT 2Sequence analysisAdd BLAST38
Repeati270 – 311HEAT 3Sequence analysisAdd BLAST42
Repeati315 – 353HEAT 4Sequence analysisAdd BLAST39
Repeati357 – 394HEAT 5Sequence analysisAdd BLAST38
Repeati396 – 433HEAT 6Sequence analysisAdd BLAST38
Repeati440 – 478HEAT 7PROSITE-ProRule annotationAdd BLAST39
Repeati587 – 624HEAT 8Sequence analysisAdd BLAST38
Repeati625 – 662HEAT 9Sequence analysisAdd BLAST38
Repeati672 – 710HEAT 10Sequence analysisAdd BLAST39
Repeati745 – 782HEAT 11Sequence analysisAdd BLAST38
Repeati856 – 893HEAT 12Sequence analysisAdd BLAST38
Repeati896 – 933HEAT 13Sequence analysisAdd BLAST38
Repeati937 – 974HEAT 14Sequence analysisAdd BLAST38
Repeati1017 – 1054HEAT 15Sequence analysisAdd BLAST38
Repeati1205 – 1242HEAT 16Sequence analysisAdd BLAST38
Repeati1272 – 1309HEAT 17Sequence analysisAdd BLAST38
Repeati1311 – 1344HEAT 18Sequence analysisAdd BLAST34
Repeati1346 – 1383HEAT 19Sequence analysisAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 516Promotes microtubule polymerization1 PublicationAdd BLAST516
Regioni1 – 505Binds tubulin1 PublicationAdd BLAST505
Regioni1 – 229TOG 11 PublicationAdd BLAST229
Regioni267 – 505TOG 21 PublicationAdd BLAST239
Regioni498 – 821Association with microtubule lattice1 PublicationAdd BLAST324
Regioni581 – 1080Promotes microtubule polymerization1 PublicationAdd BLAST500
Regioni581 – 814TOG 31 PublicationAdd BLAST234
Regioni849 – 1087TOG 41 PublicationAdd BLAST239
Regioni1099 – 1428Association with microtubule lattice1 PublicationAdd BLAST330
Regioni1179 – 1415TOG 51 PublicationAdd BLAST237

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice. TOG 1-2 show strong and TOG 3-4 weak tubulin binding; TOG 1-5 are required for full ability to promote MT polymerization.3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TOG/XMAP215 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1820, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014757

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000539_2_1_1

KEGG Orthology (KO)

More...
KOi
K16803

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024395, CLASP_N_dom
IPR021133, HEAT_type_2
IPR034085, TOG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348, CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349, TOG, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9VEZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDTEYKKL PVEERCVHKL WKARVDGYEE AAKIFRELDD EKSPEWSKFA
60 70 80 90 100
GLIKKMVVDS NALAQEKGLE AALIFVENSG LAGRTVGDVM TGIVQKCIAA
110 120 130 140 150
PKTKTKELSV QVALMYVEIE KQEAVVEELV KGMEAKNPKI VSACVAATTL
160 170 180 190 200
ALREFGHKVI GVKPLIKKLA PLMSDRDKTV RDEGKQLAVE IYRWIGAAMK
210 220 230 240 250
AQISTLPQVT LKELEDEFDK LKGERVEPSR YLKSQQEKQA KIADAAATED
260 270 280 290 300
AYNEDDGEAG VEEIDPMDLL DPVDILSKMP KDFYDKLEEK KWTLRKESLE
310 320 330 340 350
VLEKLLTDHP KLENGEYGAL VSALKKVITK DSNVVLVAMA GKCLALLAKG
360 370 380 390 400
LAKRFSNYAS ACVPSLLEKF KEKKPNVVTA LREAIDAIYA STSLEAQQES
410 420 430 440 450
IVESLSNKNP SVKSETALFI ARALTRTQPT ALNKKLLKLL TTSLVKTLNE
460 470 480 490 500
PDPTVRDSSA EALGTLIKLM GDKAVTPLLA DVDPLKMAKI KECQEKAEIK
510 520 530 540 550
IKVAGPKKET RPASAPTAKA AAPAKTVAGS VDPKPVTRPA TTGARKVLKK
560 570 580 590 600
PATVSGGGAT SAPTAALKAG GKPLATEREI TPEELQEKSE EILPAEILNG
610 620 630 640 650
LVDSNWKNRL AAVEQLLGEI SGFDAKQAGI SQILIRTISG RKPGLKEMNF
660 670 680 690 700
QVLKFKLDII RSVAENYPLT TTTVDLVINE IIEKLADAKN GAAAADVLSA
710 720 730 740 750
FAEATKLEYV VGKVLSFAFE QKSPKVQSEA FNWVNRSIIE FGFQLQPKTL
760 770 780 790 800
IEDVRKGVQS TNPTVRASAI QMVGTMSMYM GKALMMFFDS EKPALKSQIQ
810 820 830 840 850
VEFDKNVGEK PPKPVRGVQR SSGGTAGNSP DNEDDDGGAA GEEEPINMAD
860 870 880 890 900
LLPRVDIAPQ ITEALLKEMS DKDWKTRNEG LTKLQAIISE ARLIKPSIGD
910 920 930 940 950
LAPALAHRLV DSNAKIAQTT LAICEQLATA MGAGCRNHVR NLFPGFLHAL
960 970 980 990 1000
GDNKSFVRAA ALNCINSFGE KGGYKEFFES EMIADALKGG SPALKTELWA
1010 1020 1030 1040 1050
WLADKLPGLP PKSVSKEDIH SMVPHLYAHI CDRNADVRKN ANEAVLGIMI
1060 1070 1080 1090 1100
HLGFDAMNRA LDKQKPASKK DILAALEKAR PNLPVKPLPK GKHQAPIPEE
1110 1120 1130 1140 1150
PKLKTVRGGG AGGAPGIQKS ATARVAGGQD KQVPARKKDE DIDTSPLLCA
1160 1170 1180 1190 1200
NSAKNQRLLD EQKMKVLKWT FVTPREEFTE LLRDQMMTAN VNKALIANMF
1210 1220 1230 1240 1250
HDDFRYHLKV IEQLSEDLAG NSKALVCNLD LILKWLTLRF YDTNPSVLIK
1260 1270 1280 1290 1300
GLEYLVQVFQ VLIDEEYILA ENEGSSFVPH LLLKIGDPKD AVRNGVRRVL
1310 1320 1330 1340 1350
RQVILVFPFV KVFGYVMEGL KSKNARQRTE CLDELTFLIE SYGMNICPQS
1360 1370 1380 1390 1400
AVREIARQIS DRDNSVRNAA LNCIVQVFFL SGEKTYKMIG HLNEKDLSML
1410 1420 1430 1440 1450
DERIKRAKKT KKPTPPPSVD VPAPQRHDSI EIEDAEVGNG CDELPPPDED
1460 1470 1480 1490 1500
GTFDQAPSSQ LLLLQQQLQQ LQQQAQQQKP SGPFGLDSQV ISEIEKDWVR
1510 1520 1530 1540 1550
VDQMEQKPLL NVDISSLDEP IKVRPTRAGI HYPQEKFDRL ISRQHYMQQT
1560 1570 1580 1590 1600
LTTSPSSTAG MTSGVSPYRS PMRLQHQQPQ QQLENNIPNL ADVLPKHDPQ
1610 1620 1630 1640 1650
LVKVIKGVSS TDTLKARAAI NELAAIIEAP EKQAVLRDYE EIFIQNVLAQ
1660 1670 1680 1690 1700
FKNLSQIPSA QSVVVYQPLL SILYTFFHAN ILGKTLSVAC IKNLMSALLN
1710 1720 1730 1740 1750
LMADPKLAVG DDSQYNKVIN GICLKVLDKV DFTNLNCALI RLLRETCPEA
1760 1770 1780 1790 1800
KLPKFTDLLM KCIWRNVKML PERSNELNYD AVILEVHEFM LALPSTWWQN
1810 1820 1830 1840 1850
RPSDTPMRTI KTILHNMAKV KGNAILQHLN QIPTHSELHT YLIRILKNFQ
1860 1870 1880 1890 1900
KDGSASGIGA SPQRAKEIAS KRISHQTHDT VSQIFKLISD RDTKQQGLQK
1910 1920 1930 1940 1950
LYDFKQQNPD IDLSTFLQGS SAPFHKYIEE GLAEIERNQN AGSTQDNRTD
1960 1970 1980 1990 2000
VNYQNNGPDP DFWMDRLQYH MTGGAAKLAS ARSADDGSHM LDNKVVDENL
2010 2020 2030 2040
CLNGMNAQKA SLIKREKRDM SPNRLQHLQA KLAQIKKENH AQ
Length:2,042
Mass (Da):225,980
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF79B31535CE56D2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K664A0A0B4K664_DROME
Mini spindles, isoform E
msps anon-WO0140519.136, Dis1, Dmel\CG5000, MSPS, Msps
2,074Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K700A0A0B4K700_DROME
Mini spindles, isoform D
msps anon-WO0140519.136, Dis1, Dmel\CG5000, MSPS, Msps
2,082Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JIM4E1JIM4_DROME
Mini spindles, isoform B
msps anon-WO0140519.136, Dis1, Dmel\CG5000, MSPS, Msps
2,050Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55269.3
BT023496 mRNA Translation: AAY84896.1

NCBI Reference Sequences

More...
RefSeqi
NP_732105.2, NM_169698.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0301480; FBpp0290695; FBgn0027948

Database of genes from NCBI RefSeq genomes

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GeneIDi
41952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5000

UCSC genome browser

More...
UCSCi
CG5000-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55269.3
BT023496 mRNA Translation: AAY84896.1
RefSeqiNP_732105.2, NM_169698.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QK2X-ray2.10A267-505[»]
4QMHX-ray1.65A848-1084[»]
4Y5JX-ray2.30A582-825[»]
5VJCX-ray2.00A/B1141-1411[»]
SMRiQ9VEZ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ9VEZ3, 6 interactors
STRINGi7227.FBpp0293341

Proteomic databases

PRIDEiQ9VEZ3

Genome annotation databases

EnsemblMetazoaiFBtr0301480; FBpp0290695; FBgn0027948
GeneIDi41952
KEGGidme:Dmel_CG5000
UCSCiCG5000-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41952
FlyBaseiFBgn0027948, msps

Phylogenomic databases

eggNOGiKOG1820, Eukaryota
GeneTreeiENSGT00390000014757
HOGENOMiCLU_000539_2_1_1
KOiK16803

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41952, 1 hit in 1 CRISPR screen
EvolutionaryTraceiQ9VEZ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41952

Protein Ontology

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PROi
PR:Q9VEZ3

Gene expression databases

BgeeiFBgn0027948, Expressed in brain and 46 other tissues
ExpressionAtlasiQ9VEZ3, baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 5 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024395, CLASP_N_dom
IPR021133, HEAT_type_2
IPR034085, TOG
PfamiView protein in Pfam
PF12348, CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349, TOG, 5 hits
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSPS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VEZ3
Secondary accession number(s): Q4QQC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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