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Entry version 170 (17 Jun 2020)
Sequence version 2 (01 Oct 2002)
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Protein

Modular serine protease

Gene

modSP

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi (PubMed:19590012, PubMed:24794300). During Gram-positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation (PubMed:19590012). Functions in a separate pathway to the psh-mediated activation of the Toll pathway (PubMed:19590012).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei414Charge relay systemPROSITE-ProRule annotation1
Active sitei472Charge relay systemPROSITE-ProRule annotation1
Active sitei563Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processImmunity, Innate immunity

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.508

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Modular serine protease1 Publication (EC:3.4.21.-1 Publication)
Cleaved into the following 2 chains:
Modular serine protease non-catalytic chain1 Publication
Modular serine protease catalytic chain1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:modSP1 PublicationImported
Synonyms:LdlrImported
ORF Names:CG31217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0051217 modSP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype (PubMed:19590012). Viable but highly susceptible to septic injury with Gram-positive bacteria and fungi (PubMed:19590012, PubMed:24794300). Adults infected with Gram-positive bacteria E.faecalis and L.monocytogenes rapidly succumb to infection (PubMed:19590012), and display reduced expression of the antimicrobial peptide gene Drs in response to septic injury with the Gram-positive bacteria M.luteus and E.faecalis and also after injection with their purified peptidoglycans (PubMed:19590012). Adults infected with C.albicans display a severe reduction in survival after infection, and show reduced expression of Drs in response to septic injury with living C.albicans and after injection with dead C.albicans (PubMed:19590012). Moderate reduction in survival and Drs expression after infection with A.fumigatus spores (PubMed:19590012). Stage 15 embryos also display reduced survival and Drs expression after injection with M.luteus and a moderate decrease in survival after injection with proteases from the fungus A.oryzae (PubMed:24794300). No effect on survival after septic injury with the Gram-negative bacteria E.carotovora (PubMed:19590012). In adults, no effect on Drs expression after injection of proteases derived from the fungi A.oryzae and B.subtilis (PubMed:19590012). In embryos, no effect on survival or expression of the antimicrobial peptide DptA after infection with the Gram-negative bacteria Ecc15 (PubMed:24794300).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043774926 – 368Modular serine protease non-catalytic chain1 PublicationAdd BLAST343
ChainiPRO_0000437750369 – 628Modular serine protease catalytic chain1 PublicationAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi46 ↔ 63PROSITE-ProRule annotation
Disulfide bondi70 ↔ 82PROSITE-ProRule annotation
Disulfide bondi77 ↔ 95PROSITE-ProRule annotation
Disulfide bondi89 ↔ 106PROSITE-ProRule annotation
Disulfide bondi123 ↔ 135PROSITE-ProRule annotation
Disulfide bondi130 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
Disulfide bondi167 ↔ 179PROSITE-ProRule annotation
Disulfide bondi174 ↔ 192PROSITE-ProRule annotation
Disulfide bondi186 ↔ 203PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Disulfide bondi256 ↔ 283PROSITE-ProRule annotation
Disulfide bondi302 ↔ 341PROSITE-ProRule annotation
Disulfide bondi326 ↔ 354PROSITE-ProRule annotation
Glycosylationi376N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi399 ↔ 415PROSITE-ProRule annotation
Glycosylationi621N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be proteolytically cleaved via an autocatalytic mechanism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei368 – 369Cleavage1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VER6

PRoteomics IDEntifications database

More...
PRIDEi
Q9VER6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0051217 Expressed in crop (Drosophila) and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VER6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VER6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082798

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 64LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini69 – 107LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST39
Domaini122 – 163LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST42
Domaini166 – 204LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini222 – 285Sushi 1PROSITE-ProRule annotationAdd BLAST64
Domaini300 – 356Sushi 2PROSITE-ProRule annotationAdd BLAST57
Domaini369 – 621Peptidase S1PROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027452_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VER6

KEGG Orthology (KO)

More...
KOi
K20674

Identification of Orthologs from Complete Genome Data

More...
OMAi
KGRTENY

Database of Orthologous Groups

More...
OrthoDBi
267332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VER6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 2 hits
cd00112 LDLa, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 2 hits
SM00192 LDLa, 4 hits
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF57424 SSF57424, 4 hits
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 4 hits
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VER6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLISFLSNP LFFCALLLKF RTIFAACDSS QFECDNGSCI SQYDVCNGEK
60 70 80 90 100
NCPDGSDETA LTCVSQRQHC TKPYFQCTYG ACVIGTAGCN GVNECADGSD
110 120 130 140 150
ETRLRCGNED DIRQHDRRLQ GNCKENEFKC PSGICLDKSN FLCDGKDDCA
160 170 180 190 200
DGTGFDESVE LCGHMECPAY SFKCGTGGCI SGSLSCNGEN DCYDGSDEAP
210 220 230 240 250
LLCNTTKKVT TPVVTETPLE LLGCPLPLGD ERPILTGDGS RVLTGPITRG
260 270 280 290 300
TVRFSCKQGY VLEGEESSYC AKNKWSTSTI PKCVKYCSTA GEFDGYSTKA
310 320 330 340 350
LCTHNGQQVE CRKPFHPPGT EVKFVCSTGF KTLSPLPEMR CMKGGYWNRG
360 370 380 390 400
RQRCEQDCGQ LATPIKQFSS GGYTINNTVV PWHVGLYVWH NEKDYHFQCG
410 420 430 440 450
GSLLTPDLVI TAAHCVYDEG TRLPYSYDTF RVIAAKFYRN YGETTPEEKR
460 470 480 490 500
RDVRLIEIAP GYKGRTENYY QDLALLTLDE PFELSHVIRP ICVTFASFAE
510 520 530 540 550
KESVTDDVQG KFAGWNIENK HELQFVPAVS KSNSVCRRNL RDIQADKFCI
560 570 580 590 600
FTQGKSLACQ GDSGGGFTSE LPTNAFSTWN TARHFLFGVI SNAPNADQCA
610 620
HSLTVMTNIQ HFEDMILNAM NRSVETRS
Length:628
Mass (Da):69,433
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB27ED630785D338
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55354.2
AY118964 mRNA Translation: AAM50824.1
BT011129 mRNA Translation: AAR82796.1

NCBI Reference Sequences

More...
RefSeqi
NP_536776.2, NM_080515.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083353; FBpp0082798; FBgn0051217

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31217

UCSC genome browser

More...
UCSCi
CG31217-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55354.2
AY118964 mRNA Translation: AAM50824.1
BT011129 mRNA Translation: AAR82796.1
RefSeqiNP_536776.2, NM_080515.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VER6, 5 interactors
STRINGi7227.FBpp0082798

Protein family/group databases

MEROPSiS01.508

Proteomic databases

PaxDbiQ9VER6
PRIDEiQ9VER6

Genome annotation databases

EnsemblMetazoaiFBtr0083353; FBpp0082798; FBgn0051217
GeneIDi42032
KEGGidme:Dmel_CG31217
UCSCiCG31217-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42032
FlyBaseiFBgn0051217 modSP

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000167619
HOGENOMiCLU_027452_1_0_1
InParanoidiQ9VER6
KOiK20674
OMAiKGRTENY
OrthoDBi267332at2759
PhylomeDBiQ9VER6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42032 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42032

Protein Ontology

More...
PROi
PR:Q9VER6

Gene expression databases

BgeeiFBgn0051217 Expressed in crop (Drosophila) and 24 other tissues
ExpressionAtlasiQ9VER6 baseline and differential

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00112 LDLa, 4 hits
Gene3Di4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00192 LDLa, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57424 SSF57424, 4 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 4 hits
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMODSP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VER6
Secondary accession number(s): Q6NP02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. Peptidase families
    Classification of peptidase families and list of entries
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