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Entry version 150 (16 Oct 2019)
Sequence version 2 (26 Apr 2005)
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Protein

Filamin-A

Gene

cher

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the germline ring canal formation. May tether actin microfilament within the ovarian ring canal to the cell membrane. Contributes to actin microfilaments organization.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169408 ISG15 antiviral mechanism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filamin-A
Short name:
FLN-A
Alternative name(s):
Actin-binding protein 280
Short name:
ABP-280
Filamin-1
Filamin1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cher
Synonyms:cheerio, sko
ORF Names:CG3937
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014141 cher

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Shows defect in ring canal assembly and female sterility.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004211261 – 2210Filamin-AAdd BLAST2210

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VEN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Germline-specific in females (at protein level). Expressed in ovary.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout the egg-chamber development (at protein level). Expressed in the embryo.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014141 Expressed in 30 organ(s), highest expression level in female reproductive system

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VEN1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VEN1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Ten-m.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Ten-mO613074EBI-133626,EBI-118556

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67106, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VEN1, 45 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VEN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 120Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST106
Domaini139 – 242Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati249 – 347Filamin 1Add BLAST99
Repeati349 – 447Filamin 2Add BLAST99
Repeati448 – 544Filamin 3Add BLAST97
Repeati545 – 635Filamin 4Add BLAST91
Repeati638 – 734Filamin 5Add BLAST97
Repeati735 – 831Filamin 6Add BLAST97
Repeati832 – 929Filamin 7Add BLAST98
Repeati930 – 1022Filamin 8Add BLAST93
Repeati1023 – 1121Filamin 9Add BLAST99
Repeati1122 – 1217Filamin 10Add BLAST96
Repeati1218 – 1312Filamin 11Add BLAST95
Repeati1322 – 1423Filamin 12Add BLAST102
Repeati1424 – 1515Filamin 13Add BLAST92
Repeati1516 – 1603Filamin 14Add BLAST88
Repeati1606 – 1698Filamin 15Add BLAST93
Repeati1699 – 1796Filamin 16Add BLAST98
Repeati1799 – 1891Filamin 17Add BLAST93
Repeati1893 – 1986Filamin 18Add BLAST94
Repeati1988 – 2079Filamin 19Add BLAST92
Repeati2116 – 2210Filamin 20Add BLAST95

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the filamin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VEN1

KEGG Orthology (KO)

More...
KOi
K04437

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.60.40.10, 20 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 20 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9VEN1-1) [UniParc]FASTAAdd to basket
Also known as: Filamin A, filamin 240

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAERDLAED AQWKKIQQNT FTRWANEHLK TIDRSINNLE TDLSDGLRLI
60 70 80 90 100
ALIEVLSQKR MPKYNKRPTF RSQKLENVSV ALKFLQDEGI KIVNIDSSDI
110 120 130 140 150
VDCKLKLILG LIWTLILHYS ISMPMWDGED DKQLNGSGHT PKQRLLNWIH
160 170 180 190 200
AKIPDLPINN FTNDWTTGKA VGALVDACAP GLCPDWELWD PKDAVQNASE
210 220 230 240 250
AMGLADDWLN VRQLIKPEEL VNPNVDEQSM MTYLSQYPNS KLKTGAPLRP
260 270 280 290 300
KTNPNRVRAY GPGIEPIGPV VGAPANFTVE TFSAGKGSVD VDIQGPNGEI
310 320 330 340 350
EKADVRFNND KNLTYTVSYI PKSEGSHKVA VKFSGRDIPK SPFPVKVEGH
360 370 380 390 400
AGDASKVKVT GPGIQPNGVT IKKPTFFDIL AKDAGRGVPE VIIIDPANHK
410 420 430 440 450
TSVAAKVRQL ENDTWRCEYV TALQGLHSVN VFYAGTPIPN SPFPVKVAPL
460 470 480 490 500
SDARKVRASG RGLQATGVRV GDDADFKIYT EGAGEGEPEV RVIGPGGMNQ
510 520 530 540 550
NVMQSKVDGN TYECHYYPTK EGRYVIMVTF AGQEVAKSPF EVKVGPKKES
560 570 580 590 600
SIVAYGPGLS SGVIGYPAAF VVETNGETGA LGFTVAGPSQ AEIECHDNGD
610 620 630 640 650
GSALVKYHPT AVGEYAVHIL CDNEDIPKSP FIAQILPRTD FHPELVKASG
660 670 680 690 700
PGLEKNGVTI NQPTSFTVDP SKAGNAPLDV VVQDVFGTKL PVELKNNPDG
710 720 730 740 750
TKKVTYTPTS GVPHTVEVNY GGVSTPNSPH RVYVGVPVDA AKVQAFGPWL
760 770 780 790 800
QPGVRPNAAT HFNVDAREAG DAELKVKIIH EETKIEVPCR IIDNEDNTYS
810 820 830 840 850
VEVIPPSKGA YTTTMTYGGQ RVPLGEKVVV EQTVDVSKIK VDGLEPSVIM
860 870 880 890 900
NAATDFMVDM SKVGSNIDSG KLSCAIFDPM GHVLPSKIVQ GPTDDIFRIM
910 920 930 940 950
YTPFEAGRHT IELMYDNIPV PGSPFVVNVK SGCDPARCKA YGPGLEKGLT
960 970 980 990 1000
NQKNKFTVET KGAGNGGLSL AIEGPSEAKM TCTDNRDGSC DVDYLATDPG
1010 1020 1030 1040 1050
EYDITIRFAD KHIPGSPFRV LVEETVDPSK VKVYGPGIEH GQVRESVPTF
1060 1070 1080 1090 1100
FNVDVGEAGP GRIAVKLTNS EGIPVDNLRV EDKGNCIYAV HYVPPKAGSV
1110 1120 1130 1140 1150
LTCQVKFSEV EVPCSPFVMT VFPKSEPTKV KVKGVNEKKK TPASLPAEFE
1160 1170 1180 1190 1200
IDTKQAGQAD INVAIKNPKG KAMQPRLEEV STGTYVVSFV PDECGTYQCS
1210 1220 1230 1240 1250
IKYGDKEIEG SPFKLEAFPT GEAKKCKLVE QAPKIQTSGS QSHLKVDARE
1260 1270 1280 1290 1300
AGDGAVTCKI TNKAGSEIVD IDVIEKDGFF DILYALNDPG DYDINVKFGG
1310 1320 1330 1340 1350
KDIPNGSFSI KAVESIEQYS HSEYIEEHTT KVVQQTTQSE LVNGKSEITY
1360 1370 1380 1390 1400
RSVAFEKLPL PTTGGNVTAE VRMPSGKVDK PVIQDNRDGT VSVKYDPREE
1410 1420 1430 1440 1450
GSHELVVKYN GEPVQGSPFK FHVDSITSGY VTAYGPGLTH GVTGEPANFT
1460 1470 1480 1490 1500
ISTKGASAGG LTMAVEGPSK ADINYHDNKD GTVSVQYLPT APGEYQVSVR
1510 1520 1530 1540 1550
FGDKHIKGSP YFAKITGEGR KRNQISVGSC SEVTMPGDIT DDDLRALNAS
1560 1570 1580 1590 1600
IQAPSGLEEP CFLKRMPTGN IGISFTPREI GEHLVSVKRL GKHINNSPFK
1610 1620 1630 1640 1650
VTVCEREVGD AKKVKVSGTG LKEGQTHADN IFSVDTRNAG FGGLSVSIEG
1660 1670 1680 1690 1700
PSKAEIQCTD KDDGTLNISY KPTEPGYYIV NLKFADHHVE GSPFTVKVAG
1710 1720 1730 1740 1750
EGSNRKREKI QRERDAVPIT EIGSQCKLTF KMPGITSFDL AACVTSPSNV
1760 1770 1780 1790 1800
TEDAEIQEVE DGLYAVHFVP KELGVHTVSV RYSEMHIPGS PFQFTVGPLR
1810 1820 1830 1840 1850
DSGSHLVKAG GSGLERGVVG EAAEFNVWTR EAGGGSLAIS VEGPSKADIE
1860 1870 1880 1890 1900
FKDRKDGSCD VSYKVTEPGE YRVGLKFNDR HIPDSPFKVY VSPDAGDAHK
1910 1920 1930 1940 1950
LEVQQFPQGN IQADAPYQFM VRKNGAKGEL DAKIVAPSGT DDDCFIQVID
1960 1970 1980 1990 2000
GEMYSVRFYP RENGIHAIHV KFNGVHIPDS PFRIKVGKDV ADPAAVHASG
2010 2020 2030 2040 2050
NGLDEVKTGH KADFIINTCN AGVGTLAVSI DGPSKVAMDC TEVEEGYKVR
2060 2070 2080 2090 2100
YTPLLPGEHY ITVKYNNMHI VGSPFKVNAT GDKLADEGAQ ETSTVIVETV
2110 2120 2130 2140 2150
QKVAKGGKNT GVHLPTFKSD ASKVVSKGMG LKKAYIGKQN QFSISATDAG
2160 2170 2180 2190 2200
NNILYVGMYG PKGPCEEFHV KHAGHNNYNV QYLVRDRGQY VLLIKWGEEH
2210
IPGSPFQIDV
Length:2,210
Mass (Da):239,181
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA600974971A3FD84
GO
Isoform 2 (identifier: Q9VEN1-2) [UniParc]FASTAAdd to basket
Also known as: Filamin B, filamin 90

The sequence of this isoform differs from the canonical sequence as follows:
     1-1372: Missing.

Show »
Length:838
Mass (Da):90,428
Checksum:i5C86814F18DDA3CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KGT8A0A0B4KGT8_DROME
Cheerio, isoform M
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
2,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JCY6A0A0B4JCY6_DROME
Cheerio, isoform I
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
2,240Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KSF4Q7KSF4_DROME
Cheerio, isoform G
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
2,399Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHN1A0A0B4KHN1_DROME
Cheerio, isoform N
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
2,404Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z0L2B7Z0L2_DROME
Cheerio, isoform F
cher Cher, cher-RF, Dmel\CG3937, Fil, FLN
919Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V310A4V310_DROME
Cheerio, isoform H
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
857Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGB3A0A0B4KGB3_DROME
Cheerio, isoform K
cher Cher, Dmel\CG3937, Fil, FLN, FLN90
838Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF25614 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452051 – 1372Missing in isoform 2. 1 PublicationAdd BLAST1372

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF188360 mRNA Translation: AAF04108.1
AF188361 mRNA Translation: AAF04109.1
AF174492 mRNA Translation: AAF25614.1 Different initiation.
AE014297 Genomic DNA Translation: AAF55390.4
AE014297 Genomic DNA Translation: AAN13734.1
AF183182 Genomic DNA Translation: AAG43432.1

NCBI Reference Sequences

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RefSeqi
NP_001262656.1, NM_001275727.1 [Q9VEN1-2]
NP_524383.3, NM_079659.4 [Q9VEN1-1]
NP_732207.1, NM_169746.3 [Q9VEN1-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089471; FBpp0088478; FBgn0014141 [Q9VEN1-1]
FBtr0089473; FBpp0088480; FBgn0014141 [Q9VEN1-2]
FBtr0332167; FBpp0304476; FBgn0014141 [Q9VEN1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
42066

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3937

UCSC genome browser

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UCSCi
CG3937-RA d. melanogaster [Q9VEN1-1]
CG3937-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188360 mRNA Translation: AAF04108.1
AF188361 mRNA Translation: AAF04109.1
AF174492 mRNA Translation: AAF25614.1 Different initiation.
AE014297 Genomic DNA Translation: AAF55390.4
AE014297 Genomic DNA Translation: AAN13734.1
AF183182 Genomic DNA Translation: AAG43432.1
RefSeqiNP_001262656.1, NM_001275727.1 [Q9VEN1-2]
NP_524383.3, NM_079659.4 [Q9VEN1-1]
NP_732207.1, NM_169746.3 [Q9VEN1-2]

3D structure databases

SMRiQ9VEN1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67106, 62 interactors
IntActiQ9VEN1, 45 interactors

Proteomic databases

PRIDEiQ9VEN1

Genome annotation databases

EnsemblMetazoaiFBtr0089471; FBpp0088478; FBgn0014141 [Q9VEN1-1]
FBtr0089473; FBpp0088480; FBgn0014141 [Q9VEN1-2]
FBtr0332167; FBpp0304476; FBgn0014141 [Q9VEN1-2]
GeneIDi42066
KEGGidme:Dmel_CG3937
UCSCiCG3937-RA d. melanogaster [Q9VEN1-1]
CG3937-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42066
FlyBaseiFBgn0014141 cher

Phylogenomic databases

InParanoidiQ9VEN1
KOiK04437

Enzyme and pathway databases

ReactomeiR-DME-1169408 ISG15 antiviral mechanism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
cher fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42066

Protein Ontology

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PROi
PR:Q9VEN1

Gene expression databases

BgeeiFBgn0014141 Expressed in 30 organ(s), highest expression level in female reproductive system
ExpressionAtlasiQ9VEN1 baseline and differential
GenevisibleiQ9VEN1 DM

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.60.40.10, 20 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 18 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 20 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 20 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLNA_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VEN1
Secondary accession number(s): Q7KJX2
, Q7KKC2, Q9GQV1, Q9U4I3, Q9U6C0, Q9U6C1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 26, 2005
Last modified: October 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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