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Entry version 165 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Importin-13

Gene

cdm

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin-13ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdmImported
Synonyms:3R23Imported, CdmImported, CG 7212Imported, Dmel\CG7212Imported, Imp13Imported, imp13Imported, sd-5Imported
ORF Names:CG7212Imported, Dmel_CG7212Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261532, cdm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VEC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261532, Expressed in embryo and 34 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.

ARBA annotation

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3170, cdm-RanGTP complex
CPX-3171, cdm-mago-Y14 complex

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083039

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VEC5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 93Importin N-terminalInterPro annotationAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2022, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005996_3_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTFMYCY

Database of Orthologous Groups

More...
OrthoDBi
1032285at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR001494, Importin-beta_N
IPR040709, Importin_rep_1
IPR040520, Importin_rep_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03810, IBN_N, 1 hit
PF18773, Importin_rep, 1 hit
PF18806, Importin_rep_3, 1 hit
PF08389, Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VEC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPIDIARLE EAVVSFYRSN SQNQAITHEW LTDAEASPQA WQFSWQLMQL
60 70 80 90 100
GKSQEVQFFG AITLHSKLMK HWHEVPPENR EELKQKILES IVRFAGGPKI
110 120 130 140 150
VLNRLCISLG AYIVHMLGEW PGAIEEVINT FQNQRMPNVS ADVQLWIMLE
160 170 180 190 200
VLTAIPEEAQ VIHTSVKRVV LRAEIAKRVQ LVIHTVERYL KLQMNRVWDA
210 220 230 240 250
EAYSNMNRAV KCVGTWIKNI GYTIEGCVTI TAVLLEVVHK CYWPCIHAGD
260 270 280 290 300
GCMTADENEL AESCLKTMVN IIIQPDCHNY PKTAFVLIKM FLDSLSEITK
310 320 330 340 350
TEWKRENDNE DIIVHIYMLF VSSVERHSTL LLSGITSADP ELSILVHRIV
360 370 380 390 400
QEILHCTDKP GIYPVEESCS TMALAFWYML QDEVFAMSND EQKHKCWEYI
410 420 430 440 450
KPLYAHLTRI LVRKSEQPDE KSLAKWSSDD LECFRCYRQD ISDTFMYCYD
460 470 480 490 500
VLNDYILEIL AAMLDEAIAD LQRHPTHWTK LEACIYSFQS VAEHFGGEEK
510 520 530 540 550
RQIPRLMRVL AEIPYEKLNV KLLGTALETM GSYCNWLMEN PAYIPPAINL
560 570 580 590 600
LVRGLNSSMS AQATLGLKEL CRDCQLQLKP YADPLLNACH ASLNTGRMKN
610 620 630 640 650
SDSVRLMFSI GKLMSLLRPE EIPKYLDIIV SPCFEELQAI CQADSKTPAA
660 670 680 690 700
RIRTIFRLNM ISTLFSSLNT DVDEQATDQP IVQPVLLVMQ RTMPIFKRIA
710 720 730 740 750
EMWVEEIDVL EAACSAMKHA ITNLRSSFQP MLQDLCLFIV ASFQTRCCAP
760 770 780 790 800
TLEISKTAIV MFFKDEGCKP LMQQLLREFI QHSFKLFEST PEQNFSNISD
810 820 830 840 850
TMETFFGCLT QIIKKIPQVL EDKTLAYDRL VFYAQRGMTL PESGAIRNSI
860 870 880 890 900
QFLTHFVMQS RNHAHVTEVV LATGEQTLYT AMMCVGYLTP RSQVDKFADI
910 920 930 940 950
LLAMNRKYAA EMAVWMKSLM STPNFPTQLI TDADKTRYTA LIIKEKVNKR
960 970
LLQQHLSEMA MKTRGLTEKF Q
Length:971
Mass (Da):111,313
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79479AC06DCCF35E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55502.1
AY061428 mRNA Translation: AAL28976.1
AE014297 Genomic DNA Translation: AGB96076.1

NCBI Reference Sequences

More...
RefSeqi
NP_001262696.1, NM_001275767.1
NP_650682.1, NM_142425.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083619; FBpp0083039; FBgn0261532
FBtr0336472; FBpp0307575; FBgn0261532

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42171

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7212

UCSC genome browser

More...
UCSCi
CG7212-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55502.1
AY061428 mRNA Translation: AAL28976.1
AE014297 Genomic DNA Translation: AGB96076.1
RefSeqiNP_001262696.1, NM_001275767.1
NP_650682.1, NM_142425.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X1GX-ray3.35F/G1-971[»]
3ZKVX-ray3.00A1-971[»]
SMRiQ9VEC5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3170, cdm-RanGTP complex
CPX-3171, cdm-mago-Y14 complex
STRINGi7227.FBpp0083039

Proteomic databases

PRIDEiQ9VEC5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
42171

Genome annotation databases

EnsemblMetazoaiFBtr0083619; FBpp0083039; FBgn0261532
FBtr0336472; FBpp0307575; FBgn0261532
GeneIDi42171
KEGGidme:Dmel_CG7212
UCSCiCG7212-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
12582
FlyBaseiFBgn0261532, cdm

Phylogenomic databases

eggNOGiKOG2022, Eukaryota
GeneTreeiENSGT00530000063347
HOGENOMiCLU_005996_3_0_1
OMAiDTFMYCY
OrthoDBi1032285at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42171, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42171

Gene expression databases

BgeeiFBgn0261532, Expressed in embryo and 34 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR001494, Importin-beta_N
IPR040709, Importin_rep_1
IPR040520, Importin_rep_3
PfamiView protein in Pfam
PF03810, IBN_N, 1 hit
PF18773, Importin_rep, 1 hit
PF18806, Importin_rep_3, 1 hit
PF08389, Xpo1, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VEC5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VEC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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