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Protein

Ribosome production factor 2 homolog

Gene

Non3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 2 homolog
Alternative name(s):
Brix domain-containing protein 1 homolog
Novel nucleolar protein 31 Publication
Ribosome biogenesis protein RPF2 homolog
Gene namesi
Name:Non3Imported
ORF Names:CG7993Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038585 Non3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202261 – 320Ribosome production factor 2 homologAdd BLAST320

Proteomic databases

PaxDbiQ9VEB3
PRIDEiQ9VEB3

Expressioni

Gene expression databases

BgeeiFBgn0038585
ExpressionAtlasiQ9VEB3 baseline and differential
GenevisibleiQ9VEB3 DM

Interactioni

Protein-protein interaction databases

BioGridi67204, 4 interactors
IntActiQ9VEB3, 2 interactors
STRINGi7227.FBpp0082984

Structurei

3D structure databases

ProteinModelPortaliQ9VEB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 234BrixPROSITE-ProRule annotationAdd BLAST205

Sequence similaritiesi

Belongs to the RPF2 family.Curated

Phylogenomic databases

eggNOGiKOG3031 Eukaryota
COG5106 LUCA
GeneTreeiENSGT00390000007279
InParanoidiQ9VEB3
KOiK14847
OMAiKIYMRSY
OrthoDBiEOG091G0EYG
PhylomeDBiQ9VEB3

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VEB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRIRKPK TRKGKKVLLA REPQLIESAR TMLFLDGRKC GGNVKLCMKD
60 70 80 90 100
LQALKKPLVK VLNRKNDITP FDDPSSLEFL TMKNDAALFT FGSTSKKRPD
110 120 130 140 150
NIILGRIFEN EVLDMFELGI KRYQAISEFK NEKIGACVKP CLVFNGPKWA
160 170 180 190 200
QTEELRRLRN LFIDTFQREK VDSIRLQGIE HVLSFTVTDD MNILMRSYRI
210 220 230 240 250
LLKKSGQRTP RIELEEIGPS ADFSIRRTKI ASEDLYKQAR KQPKQLKVGK
260 270 280 290 300
KKNISTDALG NTKGRVHLGK QQTGSIQTRR VKALRKTPEE KKENRQRKKV
310 320
ALKAAAAEAL ASQGNNPFSS
Length:320
Mass (Da):36,498
Last modified:August 4, 2003 - v3
Checksum:iEE988944DD5226F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188T → I in AAL13477 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55514.2
AY058248 mRNA Translation: AAL13477.1
RefSeqiNP_650694.2, NM_142437.3
UniGeneiDm.4339

Genome annotation databases

EnsemblMetazoaiFBtr0083562; FBpp0082984; FBgn0038585
GeneIDi42183
KEGGidme:Dmel_CG7993
UCSCiCG7993-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRPF2_DROME
AccessioniPrimary (citable) accession number: Q9VEB3
Secondary accession number(s): Q95U84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 4, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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