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UniProtKB - Q9VE77 (Q9VE77_DROME)
Protein
V-type proton ATPase subunit a
Gene
Vha100-4
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
UniRule annotationGO - Molecular functioni
- ATPase binding Source: GO_Central
- proton-transporting ATPase activity, rotational mechanism Source: InterPro
GO - Biological processi
- proton transmembrane transport Source: FlyBase
- vacuolar acidification Source: GO_Central
Keywordsi
Biological process | Hydrogen ion transportUniRule annotationARBA annotation, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-DME-1222556, ROS and RNS production in phagocytes R-DME-6798695, Neutrophil degranulation R-DME-77387, Insulin receptor recycling R-DME-917977, Transferrin endocytosis and recycling R-DME-9639288, Amino acids regulate mTORC1 R-DME-983712, Ion channel transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit aUniRule annotation |
Gene namesi | ORF Names:CG7678Imported, Dmel_CG7678Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0038613, Vha100-4 |
VEuPathDBi | VectorBase:FBgn0038613 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- vacuolar proton-transporting V-type ATPase complex Source: GO_Central
- vacuolar proton-transporting V-type ATPase, V0 domain Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 411 – 435 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 447 – 468 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 542 – 562 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 569 – 593 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 647 – 667 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 776 – 798 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneInteractioni
GO - Molecular functioni
- ATPase binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q9VE77, 1 interactor |
STRINGi | 7227.FBpp0083073 |
Structurei
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 107 – 134 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2189, Eukaryota |
GeneTreei | ENSGT00950000182881 |
HOGENOMi | CLU_005230_0_2_1 |
OMAi | AIHTVEY |
OrthoDBi | 181796at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su IPR026028, V-type_ATPase_116kDa_su_euka |
PANTHERi | PTHR11629, PTHR11629, 1 hit |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 1 hit |
PIRSFi | PIRSF001293, ATP6V0A1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VE77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKWWSCGSN QESNSIFRSE VMSLVQMYLQ PEAAYDTIAA LGEVGCVQFR
60 70 80 90 100
DLNAKINAQQ RKFIGEVRRC DELERRIRYV TAELNKEGHK VLDLMDDFPP
110 120 130 140 150
APQPREIIDL ELHLEKTETE ILELAANNVN LQTSYLELSE MIQVLERTDQ
160 170 180 190 200
FFSDQESHNF DLNKMGTHRD PEKSNGHLGF VAGVISRERE YAFERMLWRI
210 220 230 240 250
SRGNVFVRRC DVDVALTDPK TGNVLHKSVF VVFFQGDQLQ ARIRKVCTGF
260 270 280 290 300
HAHMYPCPSS HSERQEMVKN VRTRLEDLQV IINQTSDHRT CVLQAALKQL
310 320 330 340 350
PTWSAMVKKM KGIYHTLNLF NVDLGSKCLI GEGWVPKREL ELVEVALAAG
360 370 380 390 400
SASVGSTVPS FINVLDTKKE PPTHFRTNKF TRGFQNLIDA YGIAGYREVN
410 420 430 440 450
PGLYTCITFP FLFAVMFGDM GHGTILFLLG LWMVIDEKRL SKKRGGEIWN
460 470 480 490 500
IFFAGRYIIM LMGLFAMYTG FHYNDIFSKS INVFGTRWVN VYNRTTVLTN
510 520 530 540 550
PTLQLNPSVA TRGVYPMGID PIWQSASNKI IFLNTYKMKL SIIFGVLHMV
560 570 580 590 600
FGVCMSVENF VFFKKYAYII LQFVPQVLFL LLMFGYMCFM MFYKWVKYSP
610 620 630 640 650
TTDVEADTPG CAPSVLIMFI DMVLFKTETA LPGCDVNMFP IQKNLEMIFL
660 670 680 690 700
VVALLCIPWI LLGKPLYIKY QRRNRPAGPV EEVDEIVEKI EVTTGKEIII
710 720 730 740 750
TEVAEAHESG GHSEEDDEPM SEIWIHQAIH TIEYILSTIS HTASYLRLWA
760 770 780 790 800
LSLAHAQLSE VLWTMVLAMG LQMNGYVGAI GLFFIFAVWE FFTIAIMVMM
810 820 830 840
EGLSAFLHTL RLHWVEFMSK FYVGNGYPFT PFSFKDILIV VEDD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55550.1 AY071067 mRNA Translation: AAL48689.1 |
RefSeqi | NP_650720.1, NM_142463.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0083658; FBpp0083073; FBgn0038613 |
GeneIDi | 42214 |
KEGGi | dme:Dmel_CG7678 |
UCSCi | CG7678-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55550.1 AY071067 mRNA Translation: AAL48689.1 |
RefSeqi | NP_650720.1, NM_142463.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9VE77, 1 interactor |
STRINGi | 7227.FBpp0083073 |
Protocols and materials databases
DNASUi | 42214 |
Genome annotation databases
EnsemblMetazoai | FBtr0083658; FBpp0083073; FBgn0038613 |
GeneIDi | 42214 |
KEGGi | dme:Dmel_CG7678 |
UCSCi | CG7678-RA, d. melanogaster |
Organism-specific databases
CTDi | 42214 |
FlyBasei | FBgn0038613, Vha100-4 |
VEuPathDBi | VectorBase:FBgn0038613 |
Phylogenomic databases
eggNOGi | KOG2189, Eukaryota |
GeneTreei | ENSGT00950000182881 |
HOGENOMi | CLU_005230_0_2_1 |
OMAi | AIHTVEY |
OrthoDBi | 181796at2759 |
Enzyme and pathway databases
Reactomei | R-DME-1222556, ROS and RNS production in phagocytes R-DME-6798695, Neutrophil degranulation R-DME-77387, Insulin receptor recycling R-DME-917977, Transferrin endocytosis and recycling R-DME-9639288, Amino acids regulate mTORC1 R-DME-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 42214, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42214 |
Gene expression databases
Bgeei | FBgn0038613, Expressed in midgut and 24 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su IPR026028, V-type_ATPase_116kDa_su_euka |
PANTHERi | PTHR11629, PTHR11629, 1 hit |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 1 hit |
PIRSFi | PIRSF001293, ATP6V0A1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VE77_DROME | |
Accessioni | Q9VE77Primary (citable) accession number: Q9VE77 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |