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Entry version 134 (26 Feb 2020)
Sequence version 1 (01 May 2000)
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Protein

Nuclear pore complex protein Nup58

Gene

Nup58

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-4615885 SUMOylation of DNA replication proteins
R-DME-5578749 Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup581 Publication
Alternative name(s):
Nucleoporin Nup58Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup58Imported
ORF Names:CG7360Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0038722 Nup58

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048911 – 546Nuclear pore complex protein Nup58Add BLAST546

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains O-GlcNAc (PubMed:15086791, PubMed:24706800). O-GlcNAcylation increases with increasing ambient temperature (PubMed:24706800).2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VDV3

PRoteomics IDEntifications database

More...
PRIDEi
Q9VDV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryonic development (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0038722 Expressed in embryo and 27 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VDV3 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67334, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VDV3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VDV3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 2312
Repeati36 – 3722
Repeati45 – 4632
Repeati64 – 6542
Repeati73 – 7452
Repeati82 – 8362
Repeati92 – 9372
Repeati101 – 10282
Repeati110 – 11192
Repeati119 – 120102
Repeati128 – 129112
Repeati137 – 138122
Repeati146 – 147132
Repeati155 – 156142
Repeati166 – 167152
Repeati197 – 198162
Repeati199 – 200172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 20017 X 2 AA repeats of F-GAdd BLAST179

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034851_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VDV3

KEGG Orthology (KO)

More...
KOi
K14307

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTQLRKW

Database of Orthologous Groups

More...
OrthoDBi
885529at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VDV3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024882 Nucleoporin_p58/p45
IPR024945 Spt5_C_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13437 PTHR13437, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01104 CTD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VDV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTPTTNNAI GGATAATGAF AFGARPATTT APPPSFGAAT STPTFGAAPA
60 70 80 90 100
TTSLFAAPAA TPAFGAPAAT PAFGAPASTP GFGATSTAAP AFGTAAATPA
110 120 130 140 150
FGIPAATSAF GAPAATPAFG AAAATPAFGA PAATPAFGAP AATSAFGAPA
160 170 180 190 200
ATTAFGAPAS TQASAFGAPA PAVGTVAPTF SFATPATSAP TTAPPAFGFG
210 220 230 240 250
TTATTAAAAM PASLSSGIGS FSFPKPQATT AASLNFNTTT TTATAQPFNT
260 270 280 290 300
GLKLGTTNAT TTLGGGGIFS KPAGQAAAPA ASTFVGLGGI DVTATQPKLG
310 320 330 340 350
DNKQDGIKIK ETQVPDEIIK TVDGLKAYIK QQKTISSDIG RTSTSKFTNV
360 370 380 390 400
SHEITNLKWA LQNMATLVEG SNQQIRLMRQ ETVKAIQSLE MAQRTQDTPA
410 420 430 440 450
GLQFENNAPF QYFQCLVAKY EQDLIAFRQQ IALTERHMHA ISNPQSISPD
460 470 480 490 500
DLKRGFRQLN ESFISLAGRL HEVHQRVEEH KEHYLNLRRY RLRDTTNVFE
510 520 530 540
RIDNPPLPTV EPQRISSGPT PFSNISALMN KSYAAAASSA SNATGN
Length:546
Mass (Da):55,528
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBA7C812DDBEEACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti267Missing in AAL49062 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55687.1
AY071440 mRNA Translation: AAL49062.1

NCBI Reference Sequences

More...
RefSeqi
NP_650821.2, NM_142564.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083781; FBpp0083195; FBgn0038722

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55687.1
AY071440 mRNA Translation: AAL49062.1
RefSeqiNP_650821.2, NM_142564.4

3D structure databases

SMRiQ9VDV3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67334, 7 interactors
IntActiQ9VDV3, 2 interactors
STRINGi7227.FBpp0083195

Proteomic databases

PaxDbiQ9VDV3
PRIDEiQ9VDV3

Genome annotation databases

EnsemblMetazoaiFBtr0083781; FBpp0083195; FBgn0038722
GeneIDi42342
KEGGidme:Dmel_CG7360

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9818
FlyBaseiFBgn0038722 Nup58

Phylogenomic databases

eggNOGiENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA
GeneTreeiENSGT00730000111111
HOGENOMiCLU_034851_0_0_1
InParanoidiQ9VDV3
KOiK14307
OMAiYTQLRKW
OrthoDBi885529at2759
PhylomeDBiQ9VDV3

Enzyme and pathway databases

ReactomeiR-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-4615885 SUMOylation of DNA replication proteins
R-DME-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42342

Protein Ontology

More...
PROi
PR:Q9VDV3

Gene expression databases

BgeeiFBgn0038722 Expressed in embryo and 27 other tissues
GenevisibleiQ9VDV3 DM

Family and domain databases

InterProiView protein in InterPro
IPR024882 Nucleoporin_p58/p45
IPR024945 Spt5_C_dom
PANTHERiPTHR13437 PTHR13437, 1 hit
SMARTiView protein in SMART
SM01104 CTD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP58_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VDV3
Secondary accession number(s): Q8SYM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: February 26, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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