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Protein

Probable nucleoporin Nup58

Gene

Nup58

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • structural constituent of nuclear pore Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-191859 snRNP Assembly
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nucleoporin Nup58
Gene namesi
Name:Nup58
ORF Names:CG7360
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038722 Nup58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048911 – 546Probable nucleoporin Nup58Add BLAST546

Proteomic databases

PaxDbiQ9VDV3
PRIDEiQ9VDV3

Expressioni

Gene expression databases

BgeeiFBgn0038722 Expressed in 28 organ(s), highest expression level in embryo
GenevisibleiQ9VDV3 DM

Interactioni

Protein-protein interaction databases

BioGridi67334, 7 interactors
IntActiQ9VDV3, 2 interactors
STRINGi7227.FBpp0083195

Structurei

3D structure databases

ProteinModelPortaliQ9VDV3
SMRiQ9VDV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 2312
Repeati36 – 3722
Repeati45 – 4632
Repeati64 – 6542
Repeati73 – 7452
Repeati82 – 8362
Repeati92 – 9372
Repeati101 – 10282
Repeati110 – 11192
Repeati119 – 120102
Repeati128 – 129112
Repeati137 – 138122
Repeati146 – 147132
Repeati155 – 156142
Repeati166 – 167152
Repeati197 – 198162
Repeati199 – 200172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 20017 X 2 AA repeats of F-GAdd BLAST179

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA
GeneTreeiENSGT00730000111111
InParanoidiQ9VDV3
KOiK14307
OMAiFFPSQSS
OrthoDBiEOG091G0KUR
PhylomeDBiQ9VDV3

Family and domain databases

InterProiView protein in InterPro
IPR024882 Nucleoporin_p58/p45
IPR024945 Spt5_C_dom
PANTHERiPTHR13437 PTHR13437, 1 hit
SMARTiView protein in SMART
SM01104 CTD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VDV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTPTTNNAI GGATAATGAF AFGARPATTT APPPSFGAAT STPTFGAAPA
60 70 80 90 100
TTSLFAAPAA TPAFGAPAAT PAFGAPASTP GFGATSTAAP AFGTAAATPA
110 120 130 140 150
FGIPAATSAF GAPAATPAFG AAAATPAFGA PAATPAFGAP AATSAFGAPA
160 170 180 190 200
ATTAFGAPAS TQASAFGAPA PAVGTVAPTF SFATPATSAP TTAPPAFGFG
210 220 230 240 250
TTATTAAAAM PASLSSGIGS FSFPKPQATT AASLNFNTTT TTATAQPFNT
260 270 280 290 300
GLKLGTTNAT TTLGGGGIFS KPAGQAAAPA ASTFVGLGGI DVTATQPKLG
310 320 330 340 350
DNKQDGIKIK ETQVPDEIIK TVDGLKAYIK QQKTISSDIG RTSTSKFTNV
360 370 380 390 400
SHEITNLKWA LQNMATLVEG SNQQIRLMRQ ETVKAIQSLE MAQRTQDTPA
410 420 430 440 450
GLQFENNAPF QYFQCLVAKY EQDLIAFRQQ IALTERHMHA ISNPQSISPD
460 470 480 490 500
DLKRGFRQLN ESFISLAGRL HEVHQRVEEH KEHYLNLRRY RLRDTTNVFE
510 520 530 540
RIDNPPLPTV EPQRISSGPT PFSNISALMN KSYAAAASSA SNATGN
Length:546
Mass (Da):55,528
Last modified:May 1, 2000 - v1
Checksum:iEBA7C812DDBEEACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267Missing in AAL49062 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55687.1
AY071440 mRNA Translation: AAL49062.1
RefSeqiNP_650821.2, NM_142564.4
UniGeneiDm.5932

Genome annotation databases

EnsemblMetazoaiFBtr0083781; FBpp0083195; FBgn0038722
GeneIDi42342
KEGGidme:Dmel_CG7360

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55687.1
AY071440 mRNA Translation: AAL49062.1
RefSeqiNP_650821.2, NM_142564.4
UniGeneiDm.5932

3D structure databases

ProteinModelPortaliQ9VDV3
SMRiQ9VDV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67334, 7 interactors
IntActiQ9VDV3, 2 interactors
STRINGi7227.FBpp0083195

Proteomic databases

PaxDbiQ9VDV3
PRIDEiQ9VDV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083781; FBpp0083195; FBgn0038722
GeneIDi42342
KEGGidme:Dmel_CG7360

Organism-specific databases

CTDi9818
FlyBaseiFBgn0038722 Nup58

Phylogenomic databases

eggNOGiENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA
GeneTreeiENSGT00730000111111
InParanoidiQ9VDV3
KOiK14307
OMAiFFPSQSS
OrthoDBiEOG091G0KUR
PhylomeDBiQ9VDV3

Enzyme and pathway databases

ReactomeiR-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-191859 snRNP Assembly
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

GenomeRNAii42342
PROiPR:Q9VDV3

Gene expression databases

BgeeiFBgn0038722 Expressed in 28 organ(s), highest expression level in embryo
GenevisibleiQ9VDV3 DM

Family and domain databases

InterProiView protein in InterPro
IPR024882 Nucleoporin_p58/p45
IPR024945 Spt5_C_dom
PANTHERiPTHR13437 PTHR13437, 1 hit
SMARTiView protein in SMART
SM01104 CTD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUP58_DROME
AccessioniPrimary (citable) accession number: Q9VDV3
Secondary accession number(s): Q8SYM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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