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Entry version 182 (07 Apr 2021)
Sequence version 3 (30 Nov 2010)
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Protein
Submitted name:

Apoptotic signal-regulating kinase 1, isoform C

Gene

Ask1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei614ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2559580, Oxidative Stress Induced Senescence

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9VDS9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apoptotic signal-regulating kinase 1, isoform CImported (EC:2.7.11.25Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ask1Imported
Synonyms:ASK1Imported, D-ASKImported, DASKImported, dASKImported, DASK1Imported, dASK1Imported, dAsk1Imported, Dmel\CG4720Imported, DPk92BImported, MEKK5Imported, Pk92BImported, pk92BImported
ORF Names:CG4720Imported, Dmel_CG4720Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014006, Ask1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VDS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014006, Expressed in oviduct (Drosophila) and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VDS9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VDS9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VDS9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0289484

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VDS9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini585 – 843Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 144DisorderedSequence analysisAdd BLAST21
Regioni1087 – 1140DisorderedSequence analysisAdd BLAST54
Regioni1331 – 1363DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1005 – 1025Sequence analysisAdd BLAST21
Coiled coili1150 – 1170Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 143PolarSequence analysisAdd BLAST20
Compositional biasi1095 – 1129PolarSequence analysisAdd BLAST35
Compositional biasi1331 – 1347PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4279, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171895

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VDS9

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHYGVRE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VDS9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, DUF4071, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VDS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVVCVMDTA VGDHLEDRQC ALEEIKQAVQ SAGANFQRVQ FERLDFGETN
60 70 80 90 100
VLETFYNADV AIIDLSILTQ QRPLSYHYGV RESFGMKENI LTYNDIDSKQ
110 120 130 140 150
TLSLKLSCAN YLFLSYKRNA ETNSCHLTSQ PNSGNNSKEP NAEGRVPTLQ
160 170 180 190 200
WRLKRKLQDV EIQSKAHMRE KFLSDMRTAR DTYATNGAKL QSILHEMRKR
210 220 230 240 250
LDDPHVLSGE VVHSFMCSLR DVQDYDAMVR LVNDLKNIPN TRKYVETGNM
260 270 280 290 300
SFLYAFALNR RNRKGDREKA LESSLKALEK KENHFPDMLC LCGRIYKDIF
310 320 330 340 350
VESDYTDATS LAHAIKWYRQ SFEVQPNEYA GINLATLLVI EGKEFTNTEE
360 370 380 390 400
LQHIGMTLNN LIGKKGSLSS LSEYWDVATF FEISVLANDY AKAIQAAECM
410 420 430 440 450
FKLKPPNWYL KSTIGNISLI HRFRKKPEER QPPIEEQVFQ FWMDFFLEAT
460 470 480 490 500
NTEEVKNSIR FPILILEPQK IYMPSYVTIN MDADEKSIQI VNICLAHAKN
510 520 530 540 550
ACKKIHDFLF VASKIKSVSL YKRDDRCAYL YVHHNSDDFQ IYFPSTERRQ
560 570 580 590 600
KFYDMILEMT ADQVVFVNLS NDDANIEYEY DYDEQNRKMV LGKGTYGTVY
610 620 630 640 650
AARDKQTQVR IAIKEVPEKN SQDVQPLHEE IKLHSQLRHR NIVRYLGSCS
660 670 680 690 700
ENGFFKIFME QVPGGSLSDL LETKWGPLKD NESTMAFYSK QILEGLKYLH
710 720 730 740 750
EQDIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLARINPM TETFTGTLQY
760 770 780 790 800
MAPEVIDQGV RGYGPAADIW SFGCTNVEMA TGKPPFIELG SAHAAMFKVG
810 820 830 840 850
FYKKHPNIPE ELSANAKNFI LRCFAISVMD RPSASQLLED PFLQDKPRKV
860 870 880 890 900
RPALPINTEF GRSISVPADR FVHKTTPPLS YNTTCNTPTT PELDITHSSS
910 920 930 940 950
VDIDELPSNQ FMLERRNSHG FLLSPEIEPS TPSLRTSISE TSETDGFYRL
960 970 980 990 1000
KKDSQRRTTL SKVLALDESK ICDIWLKKVD ADQNSIAIRK SDLEVLIRGL
1010 1020 1030 1040 1050
RDYIMNENEK HLEATINELK QKLNNDAVAL DHLHLALYSF QDAVVCVLRY
1060 1070 1080 1090 1100
HCIKPHWMFA LDNLVKRAVQ AAVTIFSPEL GANLADKDLS GNDDESLRTS
1110 1120 1130 1140 1150
LMQKGSTESQ EKQSLEKVLP TSNTREGVGL TPAESGGDAL SSSMECARIL
1160 1170 1180 1190 1200
RDIRDNQQKL QRQLLEQQRQ SMRALHNISQ ELAHIYMGGR KRLRRTINGF
1210 1220 1230 1240 1250
NKKCHRMSTS VGGTSGVRPN IAGNPRRQLN KHHFGLHEVD EQLEQWLTQQ
1260 1270 1280 1290 1300
EIDEFSKTLI LNEGFTFDDF IYNMEKLDLM RLGLRVGIEV RLWKLIIQER
1310 1320 1330 1340 1350
VCTSSDCVDS PPSTYHKPIG GNSSFALIDN NNTLPSPTTT TPGTPGIKTK
1360
IKKSESEYDS CSE
Length:1,363
Mass (Da):155,497
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90E0B46C4612FD40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7KSB7Q7KSB7_DROME
Apoptotic signal-regulating kinase ...
Ask1 ASK1, D-ASK, DASK, dASK, DASK1
1,196Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55711.3

NCBI Reference Sequences

More...
RefSeqi
NP_477089.3, NM_057741.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0300256; FBpp0289484; FBgn0014006

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42366

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55711.3
RefSeqiNP_477089.3, NM_057741.4

3D structure databases

SMRiQ9VDS9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VDS9, 2 interactors
STRINGi7227.FBpp0289484

Proteomic databases

PaxDbiQ9VDS9

Genome annotation databases

EnsemblMetazoaiFBtr0300256; FBpp0289484; FBgn0014006
GeneIDi42366
KEGGidme:Dmel_CG4720

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42366
FlyBaseiFBgn0014006, Ask1

Phylogenomic databases

eggNOGiKOG4279, Eukaryota
GeneTreeiENSGT00940000171895
InParanoidiQ9VDS9
OMAiYHYGVRE
PhylomeDBiQ9VDS9

Enzyme and pathway databases

ReactomeiR-DME-2559580, Oxidative Stress Induced Senescence
SignaLinkiQ9VDS9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42366, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42366

Gene expression databases

BgeeiFBgn0014006, Expressed in oviduct (Drosophila) and 38 other tissues
ExpressionAtlasiQ9VDS9, baseline and differential
GenevisibleiQ9VDS9, DM

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, DUF4071, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VDS9_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VDS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: April 7, 2021
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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