UniProtKB - Q9VDS9 (Q9VDS9_DROME)
Protein
Submitted name:
Apoptotic signal-regulating kinase 1, isoform C
Gene
Ask1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase kinase kinase activity Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: GO_Central
GO - Biological processi
- activation of MAPKK activity Source: FlyBase
- MAPK cascade Source: FlyBase
- positive regulation of JNK cascade Source: FlyBase
- positive regulation of stress-activated MAPK cascade Source: FlyBase
- regulation of adult chitin-containing cuticle pigmentation Source: FlyBase
Keywordsi
Molecular function | KinaseImported, Transferase |
Ligand | ATP-bindingARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-2559580, Oxidative Stress Induced Senescence |
SignaLinki | Q9VDS9 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ask1Imported Synonyms:ASK1Imported, D-ASKImported, DASKImported, dASKImported, DASK1Imported, dASK1Imported, dAsk1Imported, Dmel\CG4720Imported, DPk92BImported, MEKK5Imported, Pk92BImported, pk92BImported ORF Names:CG4720Imported, Dmel_CG4720Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0014006, Ask1 |
Subcellular locationi
Other locations
- protein kinase complex Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0014006, Expressed in oviduct (Drosophila) and 38 other tissues |
ExpressionAtlasi | Q9VDS9, baseline and differential |
Genevisiblei | Q9VDS9, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q9VDS9, 2 interactors |
STRINGi | 7227.FBpp0289484 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 585 – 843 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 144 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1087 – 1140 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 1331 – 1363 | DisorderedSequence analysisAdd BLAST | 33 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1005 – 1025 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1150 – 1170 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 124 – 143 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1095 – 1129 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1331 – 1347 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4279, Eukaryota |
GeneTreei | ENSGT00940000171895 |
InParanoidi | Q9VDS9 |
OMAi | YHYGVRE |
PhylomeDBi | Q9VDS9 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR043969, MAP3K_PH IPR025136, MAP3K_TRAF-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF19039, ASK_PH, 1 hit PF13281, DUF4071, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VDS9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVVCVMDTA VGDHLEDRQC ALEEIKQAVQ SAGANFQRVQ FERLDFGETN
60 70 80 90 100
VLETFYNADV AIIDLSILTQ QRPLSYHYGV RESFGMKENI LTYNDIDSKQ
110 120 130 140 150
TLSLKLSCAN YLFLSYKRNA ETNSCHLTSQ PNSGNNSKEP NAEGRVPTLQ
160 170 180 190 200
WRLKRKLQDV EIQSKAHMRE KFLSDMRTAR DTYATNGAKL QSILHEMRKR
210 220 230 240 250
LDDPHVLSGE VVHSFMCSLR DVQDYDAMVR LVNDLKNIPN TRKYVETGNM
260 270 280 290 300
SFLYAFALNR RNRKGDREKA LESSLKALEK KENHFPDMLC LCGRIYKDIF
310 320 330 340 350
VESDYTDATS LAHAIKWYRQ SFEVQPNEYA GINLATLLVI EGKEFTNTEE
360 370 380 390 400
LQHIGMTLNN LIGKKGSLSS LSEYWDVATF FEISVLANDY AKAIQAAECM
410 420 430 440 450
FKLKPPNWYL KSTIGNISLI HRFRKKPEER QPPIEEQVFQ FWMDFFLEAT
460 470 480 490 500
NTEEVKNSIR FPILILEPQK IYMPSYVTIN MDADEKSIQI VNICLAHAKN
510 520 530 540 550
ACKKIHDFLF VASKIKSVSL YKRDDRCAYL YVHHNSDDFQ IYFPSTERRQ
560 570 580 590 600
KFYDMILEMT ADQVVFVNLS NDDANIEYEY DYDEQNRKMV LGKGTYGTVY
610 620 630 640 650
AARDKQTQVR IAIKEVPEKN SQDVQPLHEE IKLHSQLRHR NIVRYLGSCS
660 670 680 690 700
ENGFFKIFME QVPGGSLSDL LETKWGPLKD NESTMAFYSK QILEGLKYLH
710 720 730 740 750
EQDIVHRDIK GDNVLVNTYS GVVKISDFGT SKRLARINPM TETFTGTLQY
760 770 780 790 800
MAPEVIDQGV RGYGPAADIW SFGCTNVEMA TGKPPFIELG SAHAAMFKVG
810 820 830 840 850
FYKKHPNIPE ELSANAKNFI LRCFAISVMD RPSASQLLED PFLQDKPRKV
860 870 880 890 900
RPALPINTEF GRSISVPADR FVHKTTPPLS YNTTCNTPTT PELDITHSSS
910 920 930 940 950
VDIDELPSNQ FMLERRNSHG FLLSPEIEPS TPSLRTSISE TSETDGFYRL
960 970 980 990 1000
KKDSQRRTTL SKVLALDESK ICDIWLKKVD ADQNSIAIRK SDLEVLIRGL
1010 1020 1030 1040 1050
RDYIMNENEK HLEATINELK QKLNNDAVAL DHLHLALYSF QDAVVCVLRY
1060 1070 1080 1090 1100
HCIKPHWMFA LDNLVKRAVQ AAVTIFSPEL GANLADKDLS GNDDESLRTS
1110 1120 1130 1140 1150
LMQKGSTESQ EKQSLEKVLP TSNTREGVGL TPAESGGDAL SSSMECARIL
1160 1170 1180 1190 1200
RDIRDNQQKL QRQLLEQQRQ SMRALHNISQ ELAHIYMGGR KRLRRTINGF
1210 1220 1230 1240 1250
NKKCHRMSTS VGGTSGVRPN IAGNPRRQLN KHHFGLHEVD EQLEQWLTQQ
1260 1270 1280 1290 1300
EIDEFSKTLI LNEGFTFDDF IYNMEKLDLM RLGLRVGIEV RLWKLIIQER
1310 1320 1330 1340 1350
VCTSSDCVDS PPSTYHKPIG GNSSFALIDN NNTLPSPTTT TPGTPGIKTK
1360
IKKSESEYDS CSE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7KSB7 | Q7KSB7_DROME | Apoptotic signal-regulating kinase ... | Ask1 ASK1, D-ASK, DASK, dASK, DASK1 | 1,196 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55711.3 |
RefSeqi | NP_477089.3, NM_057741.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0300256; FBpp0289484; FBgn0014006 |
GeneIDi | 42366 |
KEGGi | dme:Dmel_CG4720 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55711.3 |
RefSeqi | NP_477089.3, NM_057741.4 |
3D structure databases
SMRi | Q9VDS9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VDS9, 2 interactors |
STRINGi | 7227.FBpp0289484 |
Proteomic databases
PaxDbi | Q9VDS9 |
Genome annotation databases
EnsemblMetazoai | FBtr0300256; FBpp0289484; FBgn0014006 |
GeneIDi | 42366 |
KEGGi | dme:Dmel_CG4720 |
Organism-specific databases
CTDi | 42366 |
FlyBasei | FBgn0014006, Ask1 |
Phylogenomic databases
eggNOGi | KOG4279, Eukaryota |
GeneTreei | ENSGT00940000171895 |
InParanoidi | Q9VDS9 |
OMAi | YHYGVRE |
PhylomeDBi | Q9VDS9 |
Enzyme and pathway databases
Reactomei | R-DME-2559580, Oxidative Stress Induced Senescence |
SignaLinki | Q9VDS9 |
Miscellaneous databases
BioGRID-ORCSi | 42366, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42366 |
Gene expression databases
Bgeei | FBgn0014006, Expressed in oviduct (Drosophila) and 38 other tissues |
ExpressionAtlasi | Q9VDS9, baseline and differential |
Genevisiblei | Q9VDS9, DM |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR043969, MAP3K_PH IPR025136, MAP3K_TRAF-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF19039, ASK_PH, 1 hit PF13281, DUF4071, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VDS9_DROME | |
Accessioni | Q9VDS9Primary (citable) accession number: Q9VDS9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |