UniProtKB - Q9VDE3 (Q9VDE3_DROME)
Protein
Submitted name:
LD08669p
Gene
slmb
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
GO - Biological processi
- chorion-containing eggshell formation Source: FlyBase
- circadian rhythm Source: FlyBase
- dorsal appendage formation Source: FlyBase
- establishment of epithelial cell polarity Source: FlyBase
- germarium-derived egg chamber formation Source: FlyBase
- germarium-derived female germ-line cyst encapsulation Source: FlyBase
- germarium-derived female germ-line cyst formation Source: FlyBase
- locomotor rhythm Source: FlyBase
- negative regulation of apoptotic process Source: FlyBase
- negative regulation of cell population proliferation Source: FlyBase
- negative regulation of glial cell proliferation Source: FlyBase
- negative regulation of nurse cell apoptotic process Source: FlyBase
- oocyte axis specification Source: FlyBase
- oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- ovarian follicle cell stalk formation Source: FlyBase
- positive regulation of border follicle cell migration Source: FlyBase
- proteolysis Source: FlyBase
- regulation of centriole replication Source: FlyBase
- regulation of chromosome condensation Source: FlyBase
- regulation of establishment of cell polarity Source: FlyBase
- regulation of mitotic nuclear division Source: FlyBase
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Names & Taxonomyi
Protein namesi | Submitted name: LD08669pImportedSubmitted name: SlimbImportedSubmitted name: Supernumerary limbs, isoform AImportedSubmitted name: Supernumerary limbs, isoform CImported |
Gene namesi | Name:slmbImported Synonyms:BcDNA:GM02031Imported, beta-TRCPImported, beta-TrCPImported, Beta-TRCP1Imported, betaTrCPImported, crdImported, Dmel\CG3412Imported, FBXW1Imported, icaImported, l(3)00295Imported, MENE (3R)-BImported, MENE(3R)-BImported, shvImported, SLIMBImported, SlimbImported, slimbImported, SLMBImported, SlmbImported, welImported ORF Names:CG3412Imported, Dmel_CG3412Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0283468, slmb |
Subcellular locationi
Other locations
- SCF ubiquitin ligase complex Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0023423, Expressed in saliva-secreting gland and 39 other tissues |
Interactioni
Binary interactionsi
Hide detailsQ9VDE3
With | #Exp. | IntAct |
---|---|---|
Akt1 [Q8INB9] | 4 | EBI-91763,EBI-162210 |
SAK [O97143] | 2 | EBI-91763,EBI-162366 |
SkpA [O77430] | 3 | EBI-91763,EBI-180180 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
DIPi | DIP-22524N |
IntActi | Q9VDE3, 9 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 98 – 136 | F-boxInterPro annotationAdd BLAST | 39 | |
Domaini | 206 – 497 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 292 | |
Repeati | 206 – 245 | WDPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 246 – 285 | WDPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 286 – 325 | WDPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 329 – 368 | WDPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 369 – 408 | WDPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 409 – 440 | WDPROSITE-ProRule annotationAdd BLAST | 32 | |
Repeati | 458 – 488 | WDPROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159672 |
HOGENOMi | CLU_000288_103_6_1 |
OMAi | PDLKCRR |
OrthoDBi | 666965at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VDE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT
60 70 80 90 100
QWSESGQVDF VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI
110 120 130 140 150
AENILSYLDA ESLKSSELVC KEWLRVISEG MLWKKLIERK VRTDSLWRGL
160 170 180 190 200
AERRNWMQYL FKPRPGQTQR PHSFHRELFP KIMNDIDSIE NNWRTGRHML
210 220 230 240 250
RRINCRSENS KGVYCLQYDD GKIVSGLRDN TIKIWDRTDL QCVKTLMGHT
260 270 280 290 300
GSVLCLQYDD KVIISGSSDS TVRVWDVNTG EMVNTLIHHC EAVLHLRFNN
310 320 330 340 350
GMMVTCSKDR SIAVWDMTSP SEITLRRVLV GHRAAVNVVD FDEKYIVSAS
360 370 380 390 400
GDRTIKVWST SSCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNSIRLWDI
410 420 430 440 450
ECGACLRVLE GHEELVRCIR FDTKRIVSGA YDGKIKVWDL VAALDPRAAS
460 470 480 490 500
NTLCLNTLVE HTGRVFRLQF DEFQIVSSSH DDTILIWDFL NFTPNENKTG
510
RTPSPALMEH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KHK1 | A0A0B4KHK1_DROME | Supernumerary limbs, isoform B | slmb BcDNA:GM02031, beta-TRCP, beta-TrCP, Beta-TRCP1, betaTrCP | 597 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55853.1 AF222923 mRNA Translation: AAF63213.1 AF222924 mRNA Translation: AAF63214.1 AY118898 mRNA Translation: AAM50758.1 AE014297 Genomic DNA Translation: AGB96181.1 |
RefSeqi | NP_001262801.1, NM_001275872.1 NP_524430.1, NM_079706.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0084032; FBpp0083434; FBgn0283468 FBtr0333931; FBpp0306059; FBgn0283468 |
GeneIDi | 42504 |
KEGGi | dme:Dmel_CG3412 |
UCSCi | CG3412-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55853.1 AF222923 mRNA Translation: AAF63213.1 AF222924 mRNA Translation: AAF63214.1 AY118898 mRNA Translation: AAM50758.1 AE014297 Genomic DNA Translation: AGB96181.1 |
RefSeqi | NP_001262801.1, NM_001275872.1 NP_524430.1, NM_079706.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-22524N |
IntActi | Q9VDE3, 9 interactors |
Genome annotation databases
EnsemblMetazoai | FBtr0084032; FBpp0083434; FBgn0283468 FBtr0333931; FBpp0306059; FBgn0283468 |
GeneIDi | 42504 |
KEGGi | dme:Dmel_CG3412 |
UCSCi | CG3412-RA, d. melanogaster |
Organism-specific databases
CTDi | 42504 |
FlyBasei | FBgn0283468, slmb |
Phylogenomic databases
GeneTreei | ENSGT00940000159672 |
HOGENOMi | CLU_000288_103_6_1 |
OMAi | PDLKCRR |
OrthoDBi | 666965at2759 |
Miscellaneous databases
BioGRID-ORCSi | 42504, 1 hit in 3 CRISPR screens |
GenomeRNAii | 42504 |
Gene expression databases
Bgeei | FBgn0023423, Expressed in saliva-secreting gland and 39 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 5 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VDE3_DROME | |
Accessioni | Q9VDE3Primary (citable) accession number: Q9VDE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |