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UniProtKB - Q9VD99 (Q9VD99_DROME)
Protein
Submitted name:
Homeodomain-containing protein
Gene
C15
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 185 – 244 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- animal organ development Source: GO_Central
- antennal morphogenesis Source: FlyBase
- chaeta development Source: FlyBase
- elongation of arista core Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- leg disc development Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- positive regulation of transcription, DNA-templated Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeodomain-containing proteinImported |
Gene namesi | Name:C15Imported ORF Names:CG7937Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Organism-specific databases
FlyBasei | FBgn0004863, C15 |
VEuPathDBi | VectorBase:FBgn0004863 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Nucleus
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: FlyBase
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0004863, Expressed in multi-cellular organism and 25 other tissues |
ExpressionAtlasi | Q9VD99, baseline and differential |
Structurei
3D structure databases
SMRi | Q9VD99 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9VD99 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 183 – 243 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 41 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 54 – 89 | DisorderedSequence analysisAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 245 – 265 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 41 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 62 – 80 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_053409_0_0_1 |
OMAi | LHVEDHE |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042247, TLX1/2/3 |
PANTHERi | PTHR45921, PTHR45921, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VD99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCGSGSDVD MDGGSCYDES ETPLSESLQS EQTRSSSSEN LPFSISRLLS
60 70 80 90 100
KPFETSHHHH NNNNHLLSSS PGSSSNNNNS GEKGEEKELL QQEDHDLAAY
110 120 130 140 150
KLATSIANST YGSAAALYSY PHLYPSAAGG HVLRVPPQRT PLTWALPPLH
160 170 180 190 200
HAALAHQAVK DRLAAAFPIA RRIGHPYQNR TPPKRKKPRT SFTRIQVAEL
210 220 230 240 250
EKRFHKQKYL ASAERAALAR GLKMTDAQVK TWFQNRRTKW RRQTAEEREA
260 270 280 290 300
ERQAANRLML SLQAEAISKG FAPPSAPLGS QGGVNGAPLA ALHGLQPWAE
ASHAAGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22959 mRNA Translation: CAA80535.1 |
PIRi | S37252 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22959 mRNA Translation: CAA80535.1 |
PIRi | S37252 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3A01 | X-ray | 2.70 | A/E | 169-261 | [»] | |
SMRi | Q9VD99 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q9VD99, 7 interactors |
MINTi | Q9VD99 |
Organism-specific databases
FlyBasei | FBgn0004863, C15 |
VEuPathDBi | VectorBase:FBgn0004863 |
Phylogenomic databases
HOGENOMi | CLU_053409_0_0_1 |
OMAi | LHVEDHE |
Miscellaneous databases
EvolutionaryTracei | Q9VD99 |
Gene expression databases
Bgeei | FBgn0004863, Expressed in multi-cellular organism and 25 other tissues |
ExpressionAtlasi | Q9VD99, baseline and differential |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR042247, TLX1/2/3 |
PANTHERi | PTHR45921, PTHR45921, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VD99_DROME | |
Accessioni | Q9VD99Primary (citable) accession number: Q9VD99 Secondary accession number(s): Q24357, Q61678 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | July 5, 2004 | |
Last modified: | September 29, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |