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Protein

Adiponectin receptor protein

Gene

AdipoR

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi258ZincBy similarity1
Metal bindingi404ZincBy similarity1
Metal bindingi408ZincBy similarity1

GO - Molecular functioni

  • hormone binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein-hormone receptor activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processFatty acid metabolism, Lipid metabolism
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein
Gene namesi
Name:AdipoR
ORF Names:CG5315
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038984 AdipoR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 204CytoplasmicSequence analysisAdd BLAST204
Transmembranei205 – 225Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini226 – 237ExtracellularSequence analysisAdd BLAST12
Transmembranei238 – 258Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini259 – 276CytoplasmicSequence analysisAdd BLAST18
Transmembranei277 – 297Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini298 – 302ExtracellularSequence analysis5
Transmembranei303 – 323Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini324 – 334CytoplasmicSequence analysisAdd BLAST11
Transmembranei335 – 355Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini356 – 365ExtracellularSequence analysis10
Transmembranei366 – 386Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini387 – 405CytoplasmicSequence analysisAdd BLAST19
Transmembranei406 – 426Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini427 – 444ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188321 – 444Adiponectin receptor proteinAdd BLAST444

Proteomic databases

PaxDbiQ9VCY8
PRIDEiQ9VCY8

Expressioni

Tissue specificityi

In larval and adult brain, expressed in insulin-producing cells and in neurons of the subesophageal region. Also expressed in lateral neurons of the adult brain (at protein level). In third instar larvae, expressed in central nervous system (CNS), imaginal disk, salivary gland, fat body, gut and malphigian tubules.1 Publication

Developmental stagei

Expressed throughout development and in adult.1 Publication

Gene expression databases

BgeeiFBgn0038984 Expressed in 41 organ(s), highest expression level in mouthpart (Drosophila)
ExpressionAtlasiQ9VCY8 baseline and differential
GenevisibleiQ9VCY8 DM

Interactioni

Protein-protein interaction databases

BioGridi67611, 9 interactors
IntActiQ9VCY8, 5 interactors
STRINGi7227.FBpp0083675

Structurei

3D structure databases

ProteinModelPortaliQ9VCY8
SMRiQ9VCY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062926
InParanoidiQ9VCY8
KOiK07297
OMAiFHTVHCH
OrthoDBiEOG091G04EU
PhylomeDBiQ9VCY8

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9VCY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSATNLLEQ QGSAADVSGG SHPAEVEVTT QARATFGMDA EGHATGEAVT
60 70 80 90 100
TTTATLRREG SDEDIFEQVQ MILRKRRGWG PEDSLSPNDL DILEYDDELV
110 120 130 140 150
EEDDAGCPLP STPEDTQLIE AEMTEVLKAG VLSDEIDLGA LAHNAAEQAE
160 170 180 190 200
EFVRKVWEAS WKVCHYKNLP KWLQDNDFLH RGHRPPLPSF RACFKSIFRV
210 220 230 240 250
HTETGNIWTH LLGCIAFIGV ALYFISRPSV EIQTQEKIVF GAFFIGAIVC
260 270 280 290 300
LGFSFAFHTL SCHSVEMGRL FSKLDYCGIA LLIMGSFVPW LYYGFYCHYQ
310 320 330 340 350
PKVIYLSVVS ILGILSIVVS LWDKFSEPAL RPLRAGVFMS FGLSGVIPAI
360 370 380 390 400
HYSIMEGWFS QMSRASLGWL ILMGLLYILG ALLYALRVPE RWFPGKFDIW
410 420 430 440
GQSHQIFHIL VIAAAFVHYH GISEMAMYRV MYSECTVPIE PITF
Length:444
Mass (Da):49,757
Last modified:March 1, 2001 - v2
Checksum:iAAFFE1C9DA935A02
GO
Isoform 2 (identifier: Q9VCY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-122: DSLSPNDLDI...PEDTQLIEAE → MQTQPEVIVR...TVKEQAENAV

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,189
Checksum:iF96F5A0AF47E7B3A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V392A4V392_DROME
Adiponectin receptor, isoform C
AdipoR CG5315-RA, dAdipoR, Dmel\CG5315, CG5315, Dmel_CG5315
444Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0088891 – 82Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_00889083 – 122DSLSP…LIEAE → MQTQPEVIVRVNPDLEPDLS QETYRTQNPDTVKEQAENAV in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56016.2
AE014297 Genomic DNA Translation: AAF56017.3
BI585801 mRNA No translation available.
BT001487 mRNA Translation: AAN71242.1
RefSeqiNP_001247239.1, NM_001260310.2 [Q9VCY8-1]
NP_001262844.1, NM_001275915.1 [Q9VCY8-1]
NP_651061.1, NM_142804.3 [Q9VCY8-1]
NP_732758.1, NM_170019.2 [Q9VCY8-1]
NP_732759.2, NM_170020.2 [Q9VCY8-2]
UniGeneiDm.11569

Genome annotation databases

EnsemblMetazoaiFBtr0084282; FBpp0083675; FBgn0038984 [Q9VCY8-1]
FBtr0084283; FBpp0083676; FBgn0038984 [Q9VCY8-1]
FBtr0084284; FBpp0083677; FBgn0038984 [Q9VCY8-2]
FBtr0308848; FBpp0301003; FBgn0038984 [Q9VCY8-1]
FBtr0334561; FBpp0306628; FBgn0038984 [Q9VCY8-1]
GeneIDi42656
KEGGidme:Dmel_CG5315
UCSCiCG5315-RA d. melanogaster [Q9VCY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADRL_DROME
AccessioniPrimary (citable) accession number: Q9VCY8
Secondary accession number(s): Q9VCY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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