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UniProtKB - Q9VCW3 (NU133_DROME)

Entry version 169 (23 Feb 2022)
Sequence version 2 (05 Jul 2004)
Previous versions | rss
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Protein

Nuclear pore complex protein Nup133

Gene

Nup133

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance (PubMed:20547758).

Curated1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4085377, SUMOylation of SUMOylation proteins
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs
R-DME-9615933, Postmitotic nuclear pore complex (NPC) reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup133Curated
Alternative name(s):
133 kDa nucleoporinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup1331 Publication
ORF Names:CG6958Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0039004, Nup133

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0039004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004406911 – 1200Nuclear pore complex protein Nup133Add BLAST1200

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VCW3

PRoteomics IDEntifications database

More...PRIDEi		Q9VCW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0039004, Expressed in eye disc (Drosophila) and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VCW3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the Nup107-Nup160 subcomplex in the nuclear pore.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0083695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VCW3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin Nup133 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4121, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008593_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VCW3

Identification of Orthologs from Complete Genome Data

More...OMAi		RYTLHHK

Database of Orthologous Groups

More...OrthoDBi		51227at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VCW3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007187, Nucleoporin_Nup133/Nup155_C
IPR014908, Nucleoporin_Nup133/Nup155_N
IPR037624, Nup133-like
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13405, PTHR13405, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03177, Nucleoporin_C, 1 hit
PF08801, Nucleoporin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VCW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNLQKQLY GISRESSPGA RRYSMPAASA DSTRKSIFGG SASCAQMSGS 
        60         70         80         90        100
LKRTALTNSR LSLSVRSTQS IAGIRSDYNS VESFGCPLPV VVNEALTFAG 
       110        120        130        140        150
PGAGTVTAKV TQNGWAWVVQ GRRLLIWQYK DTAKSGSPPR VGKLARRGGG 
       160        170        180        190        200
LAQCRELTLP YSDLGHKSDL ISVFQTEGQQ MASCIAVSAT GEVRYWSSIA 
       210        220        230        240        250
HDGNSVDLSI LTGQEFVQLL SLPTQQGYLA VTTTCNLVFL RVGLTNGRYT 
       260        270        280        290        300
LHHKTIKPAT SFLGGFGKKF ASILIGMNTG ADKDQTLVGM CCESNLESGE 
       310        320        330        340        350
TIVAVLSDRA IQRWSLSNNG NTENLLYEDA DMLRRIREEF ITNFWKFRLP 
       360        370        380        390        400
ADSLEIDLHL LDFHVVKNKA YILAGAVNAA HAPQMCYALV TGTAQAERML 
       410        420        430        440        450
LESFTPLNMN KFFSAKTEED CLSVRFVVGS SHIYLYTSKV VYPLHLTNSV 
       460        470        480        490        500
PTAELEAEKI EFHQHDDRIL SAVICSQLPL FFSRTHGLVS ITPGDFDGTE 
       510        520        530        540        550
MMNMSSCNTP DLYAPNSCNA SFAVADHSAL TNSTNNLHLF ELDPDEMYNE 
       560        570        580        590        600
LSDEVGQLKA AFLYHMKRNS NMVKTIVDEL LRNVTAADPS GAPMDAYKLD 
       610        620        630        640        650
RIVITIAEDL AEDIPIADPR WEEALADQEM NRHAIGSSRS MQIINQLRDK 
       660        670        680        690        700
IIAFQHFITF LHSSLVWDKL NVIPCGSHSL KPTGCILADI SEKIVAAMAL 
       710        720        730        740        750
RSIQTKLPKL IEEAIDATVA LWHEEPQGSL TYQDIFYVKL SRFQNVFEAL 
       760        770        780        790        800
ADIADDRIAA QNQTTISVAH FVNEINSIVL DVLGQVFKYR KQHASSFRLS 
       810        820        830        840        850
HEKLPSYENL PWTAMAGSAG VRDTLTRLID ISVRYGSHCV SETELKQQLY 
       860        870        880        890        900
QQIFELIDLV LDGRKTYLKS VRDTEKFNVL QQQFEAQRRE LISVLIKDRQ 
       910        920        930        940        950
YEYAAKIAEK YLDFQSLVLI CDETQDKERL EDYTRKYEEY DFSQFAINWH 
       960        970        980        990       1000
LRQNRHGEVF ERFKGNQTAL AQFMRDHPSL GWIQLIFNGD FERAAKVLYE 
      1010       1020       1030       1040       1050
LAQCETEFVA RKKSMLSLAK LAAFAAAESD LTAQVEKINA DLTLVEYQSQ 
      1060       1070       1080       1090       1100
LGHDVLESFG FDPAEQKVLK AEEIISLYIA EENETASETE FRKALELLSY 
      1110       1120       1130       1140       1150
VEQPYDMRHK IWCAAIKRDN WTDYDPNNAV HYMQKLLFYK IIEISQLMGN 
      1160       1170       1180       1190       1200
DSENVLPPME DFLESVELGD LPQQKPFQYL LKLTYEYVAD MFKQPDDMEL
Length:1,200
Mass (Da):135,147
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE2A38685CB2EA69
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK93145 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56042.2
BT003226 mRNA Translation: AAO24981.1
AY051721 mRNA Translation: AAK93145.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_651080.2, NM_142823.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0084302; FBpp0083695; FBgn0039004

Database of genes from NCBI RefSeq genomes

More...GeneIDi		42680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG6958

UCSC genome browser

More...UCSCi		CG6958-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56042.2
BT003226 mRNA Translation: AAO24981.1
AY051721 mRNA Translation: AAK93145.1 Different initiation.
RefSeqiNP_651080.2, NM_142823.3

3D structure databases

SMRiQ9VCW3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0083695

Proteomic databases

PaxDbiQ9VCW3
PRIDEiQ9VCW3

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		42680

Genome annotation databases

EnsemblMetazoaiFBtr0084302; FBpp0083695; FBgn0039004
GeneIDi42680
KEGGidme:Dmel_CG6958
UCSCiCG6958-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55746
FlyBaseiFBgn0039004, Nup133
VEuPathDBiVectorBase:FBgn0039004

Phylogenomic databases

eggNOGiKOG4121, Eukaryota
GeneTreeiENSGT00390000011529
HOGENOMiCLU_008593_1_0_1
InParanoidiQ9VCW3
OMAiRYTLHHK
OrthoDBi51227at2759
PhylomeDBiQ9VCW3

Enzyme and pathway databases

ReactomeiR-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4085377, SUMOylation of SUMOylation proteins
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs
R-DME-9615933, Postmitotic nuclear pore complex (NPC) reformation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		42680, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		42680

Protein Ontology

More...PROi		PR:Q9VCW3

Gene expression databases

BgeeiFBgn0039004, Expressed in eye disc (Drosophila) and 34 other tissues
ExpressionAtlasiQ9VCW3, baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR007187, Nucleoporin_Nup133/Nup155_C
IPR014908, Nucleoporin_Nup133/Nup155_N
IPR037624, Nup133-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13405, PTHR13405, 1 hit
PfamiView protein in Pfam
PF03177, Nucleoporin_C, 1 hit
PF08801, Nucleoporin_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU133_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VCW3
Secondary accession number(s): Q86PB8, Q961A9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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