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UniProtKB - Q9VCW1 (CP6D4_DROME)
Protein
Probable cytochrome P450 6d4
Gene
Cyp6d4
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 457 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp6d4 ORF Names:CG12800 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0039006, Cyp6d4 |
VEuPathDBi | VectorBase:FBgn0039006 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051881 | 1 – 515 | Probable cytochrome P450 6d4Add BLAST | 515 |
Proteomic databases
PaxDbi | Q9VCW1 |
PRIDEi | Q9VCW1 |
Expressioni
Gene expression databases
Bgeei | FBgn0039006, Expressed in multi-cellular organism and 40 other tissues |
Genevisiblei | Q9VCW1, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 67632, 8 interactors |
IntActi | Q9VCW1, 3 interactors |
STRINGi | 7227.FBpp0083697 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000168877 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9VCW1 |
OMAi | VMQTYAI |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9VCW1 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VCW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSLILLAVT LLTLAWFYLK RHYEYWERRG FPFEKHSGIP FGCLDSVWRQ
60 70 80 90 100
EKSMGLAIYD VYVKSKERVL GIYLLFRPAV LIRDADLARR VLAQDFASFH
110 120 130 140 150
DRGVYVDEER DPLSANIFSL RGQSWRSMRH MLSPCFTSGK LKSMFSTSED
160 170 180 190 200
IGDKMVAHLQ KELPEEGFKE VDIKKVMQNY AIDIIASTIF GLDVNSFENP
210 220 230 240 250
DNKFRKLVSL ARANNRFNAM FGMMIFLVPS IAQFLFRIGF KNPVGLAMLQ
260 270 280 290 300
IVKETVEYRE KHGIVRKDLL QLLIQLRNTG KIDENDEKSF SIQKTPDGHI
310 320 330 340 350
KTISLEAITA QAFIFYIAGQ ETTGSTAAFT IYELAQYPEL LKRLQDEVDE
360 370 380 390 400
TLAKNDGKIT YDSLNKMEFL DLCVQETIRK YPGLPILNRE CTQDYTVPDT
410 420 430 440 450
NHVIPKGTPV VISLYGIHHD AEYFPDPETY DPERFSEESR NYNPTAFMPF
460 470 480 490 500
GEGPRICIAQ RMGRINSKLA IIKILQNFNV EVMSRSEIEF ENSGIALIPK
510
HGVRVRLSKR VPKLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56044.1 AY051606 mRNA Translation: AAK93030.1 |
RefSeqi | NP_651082.1, NM_142825.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0084304; FBpp0083697; FBgn0039006 |
GeneIDi | 42682 |
KEGGi | dme:Dmel_CG12800 |
UCSCi | CG12800-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56044.1 AY051606 mRNA Translation: AAK93030.1 |
RefSeqi | NP_651082.1, NM_142825.4 |
3D structure databases
SMRi | Q9VCW1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 67632, 8 interactors |
IntActi | Q9VCW1, 3 interactors |
STRINGi | 7227.FBpp0083697 |
Proteomic databases
PaxDbi | Q9VCW1 |
PRIDEi | Q9VCW1 |
Protocols and materials databases
DNASUi | 42682 |
Genome annotation databases
EnsemblMetazoai | FBtr0084304; FBpp0083697; FBgn0039006 |
GeneIDi | 42682 |
KEGGi | dme:Dmel_CG12800 |
UCSCi | CG12800-RA, d. melanogaster |
Organism-specific databases
CTDi | 42682 |
FlyBasei | FBgn0039006, Cyp6d4 |
VEuPathDBi | VectorBase:FBgn0039006 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000168877 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9VCW1 |
OMAi | VMQTYAI |
OrthoDBi | 467733at2759 |
PhylomeDBi | Q9VCW1 |
Miscellaneous databases
BioGRID-ORCSi | 42682, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42682 |
PROi | PR:Q9VCW1 |
Gene expression databases
Bgeei | FBgn0039006, Expressed in multi-cellular organism and 40 other tissues |
Genevisiblei | Q9VCW1, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP6D4_DROME | |
Accessioni | Q9VCW1Primary (citable) accession number: Q9VCW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | September 29, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families