UniProtKB - Q9VCN6 (Q9VCN6_DROME)
Protein
Submitted name:
Cell division cycle 16
Gene
Cdc16
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: GO_Central
- cell division Source: GO_Central
- compound eye photoreceptor cell differentiation Source: FlyBase
- metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
- mitotic cell cycle Source: FlyBase
- negative regulation of canonical Wnt signaling pathway Source: FlyBase
- positive regulation of mitotic metaphase/anaphase transition Source: FlyBase
- protein catabolic process Source: FlyBase
- protein ubiquitination Source: GO_Central
- regulation of mitotic metaphase/anaphase transition Source: FlyBase
Keywordsi
Biological process | Cell cycle, Cell divisionImported |
Enzyme and pathway databases
Reactomei | R-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176412, Phosphorylation of the APC/C R-DME-179409, APC-Cdc20 mediated degradation of Nek2A R-DME-2467813, Separation of Sister Chromatids R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Submitted name: Cell division cycle 16Imported |
Gene namesi | Name:Cdc16Imported Synonyms:APC6Imported, Apc6Imported, CDC16Imported, cdc16Imported, Dmcdc16Imported, Dmel\CG6759Imported ORF Names:CG6759Imported, Dmel_CG6759Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0025781, Cdc16 |
Subcellular locationi
Nucleus
- anaphase-promoting complex Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | FBgn0025781, Expressed in embryo and 33 other tissues |
ExpressionAtlasi | Q9VCN6, baseline and differential |
Genevisiblei | Q9VCN6, DM |
Interactioni
Protein-protein interaction databases
DIPi | DIP-60668N |
IntActi | Q9VCN6, 1 interactor |
STRINGi | 7227.FBpp0083769 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 152 – 185 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 373 – 641 | TPR_REGIONInterPro annotationAdd BLAST | 269 | |
Repeati | 426 – 459 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 460 – 493 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 574 – 607 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 608 – 641 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1173, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_011751_3_2_1 |
InParanoidi | Q9VCN6 |
OMAi | QFIDMRR |
OrthoDBi | 905026at2759 |
PhylomeDBi | Q9VCN6 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
SMARTi | View protein in SMART SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VCN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGDTENTST DTTNEHIDLA LYRQLVKQFI DMRRYSTALF WAEKVAVLGG
60 70 80 90 100
LEPRDIYYQA QCMYLLGEYH RAAHTIQHHK LEKNSLPCFN LLLESLYAAK
110 120 130 140 150
EFTEAANVIQ NVEVEVMTTS LINQPVDASS GCYLESNSVF GGEENHRNEL
160 170 180 190 200
LSSIYLMKGK VYEALDNRGM AMDFYVQALH KSIYCFEALE ALVQHEMLMA
210 220 230 240 250
WEEFELMHHL PLAQQSSEAD AKFILKLYES RLKKYYELIS ARNAEEMSPI
260 270 280 290 300
VNPDILQFIK EFTARVQQSG SSDTQMPKVS AVKVPLTPSQ FMSPAQKVLE
310 320 330 340 350
DLKAPTFSLQ TSLSKASSLI DASHRSMFDS SSRRRSRDHD TDTLIPIAEC
360 370 380 390 400
LDRVQRSTDL MAAEAEKCFY DCDYKQCLKI LNELLKVDPF HNTALTIQIA
410 420 430 440 450
CLVENGDFNR LFYVAHKLVD RYPDKAISWY AVGCYYDMIG KSDPARRYLS
460 470 480 490 500
KATALDRLYG PAWLAYGHSF ANENEHEQAM AAYFKATQLM RGCHLPLLYI
510 520 530 540 550
GVECGLTKNL ELAEKFFLQA MNIAPLDVYV LHELGVIKYE YEFFDGAATI
560 570 580 590 600
FQCTVDIVKQ RAKSNNEEIS SRWEPLFINL GHSLRKVHKY EEALYNFQYA
610 620 630 640 650
LLLKPQSPTT YTSIGFIHAL LGNLDPAIEA FHKSLALNRD CIVTSTILKS
660 670 680 690 700
CIEDLMDDSA TIDEICSAAL RDVAKNITAN SRRVLNSDKF NGMKLKFDEE
710
EEFANSDSNM VVEMSFDT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56121.1 |
RefSeqi | NP_477397.1, NM_058049.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0084377; FBpp0083769; FBgn0025781 |
GeneIDi | 42753 |
KEGGi | dme:Dmel_CG6759 |
UCSCi | CG6759-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56121.1 |
RefSeqi | NP_477397.1, NM_058049.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-60668N |
IntActi | Q9VCN6, 1 interactor |
STRINGi | 7227.FBpp0083769 |
Proteomic databases
PaxDbi | Q9VCN6 |
Genome annotation databases
EnsemblMetazoai | FBtr0084377; FBpp0083769; FBgn0025781 |
GeneIDi | 42753 |
KEGGi | dme:Dmel_CG6759 |
UCSCi | CG6759-RA, d. melanogaster |
Organism-specific databases
CTDi | 8881 |
FlyBasei | FBgn0025781, Cdc16 |
Phylogenomic databases
eggNOGi | KOG1173, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_011751_3_2_1 |
InParanoidi | Q9VCN6 |
OMAi | QFIDMRR |
OrthoDBi | 905026at2759 |
PhylomeDBi | Q9VCN6 |
Enzyme and pathway databases
Reactomei | R-DME-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176408, Regulation of APC/C activators between G1/S and early anaphase R-DME-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176412, Phosphorylation of the APC/C R-DME-179409, APC-Cdc20 mediated degradation of Nek2A R-DME-2467813, Separation of Sister Chromatids R-DME-2559582, Senescence-Associated Secretory Phenotype (SASP) R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 42753, 0 hits in 1 CRISPR screen |
GenomeRNAii | 42753 |
Gene expression databases
Bgeei | FBgn0025781, Expressed in embryo and 33 other tissues |
ExpressionAtlasi | Q9VCN6, baseline and differential |
Genevisiblei | Q9VCN6, DM |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
SMARTi | View protein in SMART SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VCN6_DROME | |
Accessioni | Q9VCN6Primary (citable) accession number: Q9VCN6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |