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Entry version 116 (03 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Nucleoporin Ndc1

Gene

Ndc1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4615885 SUMOylation of DNA replication proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin Ndc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ndc1
ORF Names:CG5857
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0039125 Ndc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 60Perinuclear spaceSequence analysisAdd BLAST18
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 106CytoplasmicSequence analysisAdd BLAST25
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 144Perinuclear spaceSequence analysisAdd BLAST17
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 200CytoplasmicSequence analysisAdd BLAST35
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 239Perinuclear spaceSequence analysisAdd BLAST18
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 578CytoplasmicSequence analysisAdd BLAST318

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002352481 – 578Nucleoporin Ndc1Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei414Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VCG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9VCG4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VCG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0039125 Expressed in 4 organ(s), highest expression level in adult organism

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VCG4 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67761, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VCG4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VCG4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4358 Eukaryota
ENOG4110XEC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014590

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VCG4

KEGG Orthology (KO)

More...
KOi
K14315

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFKLPHA

Database of Orthologous Groups

More...
OrthoDBi
556184at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VCG4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019049 Nucleoporin_prot_Ndc1/Nup

The PANTHER Classification System

More...
PANTHERi
PTHR13269 PTHR13269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09531 Ndc1_Nup, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VCG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASSSSNAC KLLLLGRCLR AVLLSVAIQF LLLTVFLLFV NFQLLHPLAW
60 70 80 90 100
VTGTLRLVAS WYTWFASIPL VASVVLYGVI LCQQHLSERR YCPTRYRWLL
110 120 130 140 150
HYGPRKVLFL FAHLLVGLLT AWLYTGYLHT DYQHLKYKCY GQDCISAYNV
160 170 180 190 200
YLLGIGMTAG CYYFVSVHMR KEISIEFPIV EQSRAEKMRE LLYASLAKSL
210 220 230 240 250
LSSLLPTISY TAVFCLFGPM VCHRLSHILS VDMDERLDGF FGVVTNVRLL
260 270 280 290 300
FYGYLLTAQI LSNMHLMRCF YGILLSEDLP LVVTKPRAAF AHEQDITLVA
310 320 330 340 350
GLGVFNVYVV QCLAAHHFYK LALRKNSPQR AEIFQLTEPG NRPASWRSLC
360 370 380 390 400
DQCLSILGSF TEELTESMQK ISILKCAQSL PMPKITESLT TSLMAEKVLL
410 420 430 440 450
RQYNQKHGIR PIVSPSREVA VESPADGIRH FPNWCERVST QLEQSLQRLL
460 470 480 490 500
QRVPGIVYLF NEPEGAKTTF LLANSLPVVY MTQALAQVCA ASLKEDPYGV
510 520 530 540 550
VQNDLPAIIK AINKLRNELD KLSSVIGNIR ISSSSFNVLR CAVRRSLYAI
560 570
CLSFCDYLDD LLPPGEELRQ LQDLVCQE
Length:578
Mass (Da):65,387
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB298547FE0B5D88A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti437 – 438RV → LL in AAZ73088 (Ref. 1) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ141697 mRNA Translation: AAZ73088.1
AE014297 Genomic DNA Translation: AAF56202.1
AY061468 mRNA Translation: AAL29016.1

NCBI Reference Sequences

More...
RefSeqi
NP_651191.1, NM_142934.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084491; FBpp0083879; FBgn0039125

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5857

UCSC genome browser

More...
UCSCi
CG5857-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141697 mRNA Translation: AAZ73088.1
AE014297 Genomic DNA Translation: AAF56202.1
AY061468 mRNA Translation: AAL29016.1
RefSeqiNP_651191.1, NM_142934.4

3D structure databases

SMRiQ9VCG4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67761, 5 interactors
IntActiQ9VCG4, 1 interactor
STRINGi7227.FBpp0083879

PTM databases

iPTMnetiQ9VCG4

Proteomic databases

PaxDbiQ9VCG4
PRIDEiQ9VCG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084491; FBpp0083879; FBgn0039125
GeneIDi42825
KEGGidme:Dmel_CG5857
UCSCiCG5857-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55706
FlyBaseiFBgn0039125 Ndc1

Phylogenomic databases

eggNOGiKOG4358 Eukaryota
ENOG4110XEC LUCA
GeneTreeiENSGT00390000014590
InParanoidiQ9VCG4
KOiK14315
OMAiHFKLPHA
OrthoDBi556184at2759
PhylomeDBiQ9VCG4

Enzyme and pathway databases

ReactomeiR-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4615885 SUMOylation of DNA replication proteins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42825

Protein Ontology

More...
PROi
PR:Q9VCG4

Gene expression databases

BgeeiFBgn0039125 Expressed in 4 organ(s), highest expression level in adult organism
GenevisibleiQ9VCG4 DM

Family and domain databases

InterProiView protein in InterPro
IPR019049 Nucleoporin_prot_Ndc1/Nup
PANTHERiPTHR13269 PTHR13269, 1 hit
PfamiView protein in Pfam
PF09531 Ndc1_Nup, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDC1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VCG4
Secondary accession number(s): Q3YE69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 2000
Last modified: July 3, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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