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Protein

Beclin-1-like protein

Gene

Atg6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • autophagy Source: FlyBase
  • autophagy of nucleus Source: GO_Central
  • cellular response to nitrogen starvation Source: GO_Central
  • cellular response to starvation Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • endocytosis Source: FlyBase
  • glycophagy Source: FlyBase
  • hemopoiesis Source: FlyBase
  • larval midgut cell programmed cell death Source: FlyBase
  • late endosome to vacuole transport Source: GO_Central
  • negative regulation of innate immune response Source: FlyBase
  • neuron remodeling Source: FlyBase
  • protein secretion Source: FlyBase
  • response to oxidative stress Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-1632852 Macroautophagy
R-DME-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Beclin-1-like protein
Alternative name(s):
Autophagy protein 6-like
Short name:
APG6-like
Gene namesi
Name:Atg6
ORF Names:CG5429
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0264325 Atg6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185571 – 422Beclin-1-like proteinAdd BLAST422

Proteomic databases

PaxDbiQ9VCE1
PRIDEiQ9VCE1

Expressioni

Gene expression databases

BgeeiFBgn0264325
GenevisibleiQ9VCE1 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rpt6O184133EBI-134130,EBI-174806

Protein-protein interaction databases

BioGridi67784, 11 interactors
DIPiDIP-22026N
IntActiQ9VCE1, 1 interactor
STRINGi7227.FBpp0083975

Structurei

3D structure databases

ProteinModelPortaliQ9VCE1
SMRiQ9VCE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 243Sequence analysisAdd BLAST125

Sequence similaritiesi

Belongs to the beclin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2751 Eukaryota
ENOG410XQ85 LUCA
GeneTreeiENSGT00390000008164
InParanoidiQ9VCE1
KOiK08334
OMAiMRYAQMQ
OrthoDBiEOG091G0COC
PhylomeDBiQ9VCE1

Family and domain databases

Gene3Di1.10.418.40, 1 hit
InterProiView protein in InterPro
IPR007243 Atg6/Beclin
IPR038274 Atg6/Beclin_C_sf
PANTHERiPTHR12768 PTHR12768, 1 hit
PfamiView protein in Pfam
PF04111 APG6, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VCE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAEKQAVS FACQRCLQPI VLDEQLEKIS VHAMAELSLP IYGDNGNTLD
60 70 80 90 100
PQDASSFDHF VPPYRLTDSI NGTGFMLVSD GRDNKKMSAA FKLKAELFDC
110 120 130 140 150
LSSNSEIDHP LCEECADSML EIMDRELRIA EDEWDVYKAY LDELEQQRVA
160 170 180 190 200
PNVEALDKEL DELKRSEQQL LSELKELKKE EQSLNDAIAE EEQEREELHE
210 220 230 240 250
QEESYWREYT KHRRELMLTE DDKRSLECQI AYSKQQLDKL RDTNIFNITF
260 270 280 290 300
HIWHAGHFGT INNFRLGRLP SVSVDWSEIN AAWGQTVLLL SALARKIGLT
310 320 330 340 350
FERYRVVPFG NHSYVEVLGE NRELPLYGSG GFKFFWDTKF DAAMVAFLDC
360 370 380 390 400
LTQFQKEVEK RDTEFLLPYK MEKGKIIDPS TGNSYSIKIQ FNSEEQWTKA
410 420
LKFMLTNLKW GLAWVSSQFV SP
Length:422
Mass (Da):48,870
Last modified:May 1, 2000 - v1
Checksum:i046B96E776667635
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56227.1
AY061424 mRNA Translation: AAL28972.1
RefSeqiNP_651209.1, NM_142952.3
UniGeneiDm.20240

Genome annotation databases

EnsemblMetazoaiFBtr0084590; FBpp0083975; FBgn0264325
GeneIDi42850
KEGGidme:Dmel_CG5429

Similar proteinsi

Entry informationi

Entry nameiBECN1_DROME
AccessioniPrimary (citable) accession number: Q9VCE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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