UniProtKB - Q9VCC0 (CHRD1_DROME)
Protein
Cysteine and histidine-rich domain-containing protein
Gene
CHORD
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Regulates centrosome duplication.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 4 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 9 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 23 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 26 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 41 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 42 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 58 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 63 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 140 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 145 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 159 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 162 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 177 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 178 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 194 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 199 | Zinc 3PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- zinc ion binding Source: GO_Central
GO - Biological processi
- centrosome duplication Source: FlyBase
- regulation of cell size Source: FlyBase
- regulation of dendrite development Source: FlyBase
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine and histidine-rich domain-containing proteinAlternative name(s): Morgana |
Gene namesi | Name:CHORD Synonyms:mora ORF Names:CG6198 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0029503, CHORD |
Pathology & Biotechi
Disruption phenotypei
Results in centrosome amplification and lethality. Cells become polyploid or undergo apoptosis. Homozygotes died as third instar larvae.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000402803 | 1 – 354 | Cysteine and histidine-rich domain-containing proteinAdd BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 324 | Phosphoserine2 Publications | 1 | |
Modified residuei | 339 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9VCC0 |
PRIDEi | Q9VCC0 |
PTM databases
iPTMneti | Q9VCC0 |
Expressioni
Gene expression databases
Bgeei | FBgn0029503, Expressed in egg chamber and 24 other tissues |
Genevisiblei | Q9VCC0, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 67806, 4 interactors |
IntActi | Q9VCC0, 1 interactor |
STRINGi | 7227.FBpp0083939 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 63 | CHORD 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 140 – 199 | CHORD 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 210 – 301 | CSPROSITE-ProRule annotationAdd BLAST | 92 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1667, Eukaryota |
GeneTreei | ENSGT00940000159429 |
HOGENOMi | CLU_040079_0_0_1 |
InParanoidi | Q9VCC0 |
OMAi | KKVVQCR |
OrthoDBi | 1163528at2759 |
PhylomeDBi | Q9VCC0 |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR007051, CHORD_dom IPR007052, CS_dom IPR008978, HSP20-like_chaperone |
Pfami | View protein in Pfam PF04968, CHORD, 2 hits PF04969, CS, 1 hit |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS51401, CHORD, 2 hits PS51203, CS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VCC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQCYNRGCG QLFDPQTNND ESCRHHPGEP FFHDAYKGWS CCNKKSVDFT
60 70 80 90 100
EFLNIKGCTL AKHSNVKPPE PEKPVKDESD KDEVIEVRAP IREALPRPPI
110 120 130 140 150
DSPLTVIQPT VAPALKDMVF AVKTPAAQKS SDAIEVGTTC KNNGCTYSFT
160 170 180 190 200
GNSSDFGECT YHPGVPIFHE GMKFWSCCQK RTSDFSQFMA QKGCTYGEHK
210 220 230 240 250
WVKENDDKKV VQCRYDWHQT ATNVVMAIYA KKYDYSQSVI ELNPIRLHVN
260 270 280 290 300
LVFPEQDNAR FDLDLELRGI VNVSNASAHM YGTKVEIKLP KLEPGSWSNL
310 320 330 340 350
NFPNKKLPVV KKSQVEEKKK QEESDEEFFD LDDIKAETSF RLSEMSMQSP
NNLD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 288 | K → T in AAF18436 (PubMed:10571178).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF192465 mRNA Translation: AAF18436.1 AE014297 Genomic DNA Translation: AAF56252.1 AY070947 mRNA Translation: AAL48569.1 |
RefSeqi | NP_651226.1, NM_142969.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0084554; FBpp0083939; FBgn0029503 |
GeneIDi | 42874 |
KEGGi | dme:Dmel_CG6198 |
UCSCi | CG6198-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF192465 mRNA Translation: AAF18436.1 AE014297 Genomic DNA Translation: AAF56252.1 AY070947 mRNA Translation: AAL48569.1 |
RefSeqi | NP_651226.1, NM_142969.4 |
3D structure databases
SMRi | Q9VCC0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 67806, 4 interactors |
IntActi | Q9VCC0, 1 interactor |
STRINGi | 7227.FBpp0083939 |
PTM databases
iPTMneti | Q9VCC0 |
Proteomic databases
PaxDbi | Q9VCC0 |
PRIDEi | Q9VCC0 |
Genome annotation databases
EnsemblMetazoai | FBtr0084554; FBpp0083939; FBgn0029503 |
GeneIDi | 42874 |
KEGGi | dme:Dmel_CG6198 |
UCSCi | CG6198-RA, d. melanogaster |
Organism-specific databases
CTDi | 42874 |
FlyBasei | FBgn0029503, CHORD |
Phylogenomic databases
eggNOGi | KOG1667, Eukaryota |
GeneTreei | ENSGT00940000159429 |
HOGENOMi | CLU_040079_0_0_1 |
InParanoidi | Q9VCC0 |
OMAi | KKVVQCR |
OrthoDBi | 1163528at2759 |
PhylomeDBi | Q9VCC0 |
Miscellaneous databases
BioGRID-ORCSi | 42874, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42874 |
PROi | PR:Q9VCC0 |
Gene expression databases
Bgeei | FBgn0029503, Expressed in egg chamber and 24 other tissues |
Genevisiblei | Q9VCC0, DM |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR007051, CHORD_dom IPR007052, CS_dom IPR008978, HSP20-like_chaperone |
Pfami | View protein in Pfam PF04968, CHORD, 2 hits PF04969, CS, 1 hit |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS51401, CHORD, 2 hits PS51203, CS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHRD1_DROME | |
Accessioni | Q9VCC0Primary (citable) accession number: Q9VCC0 Secondary accession number(s): Q9U4A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2011 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase