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Entry version 177 (25 May 2022)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Java no jive

Gene

jnj

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Java no jiveImported
Submitted name:
SD25546pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:jnjImported
Synonyms:AAF56254Imported, Dmel\CG5524Imported, Huc-95DEImported, huc95EImported, huc[95D-E]Imported, huc[95DE]Imported, huc[95E]Imported, SMC6Imported, Smc6Imported, smc6Imported
ORF Names:CG5524Imported, Dmel_CG5524Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0266282, jnj

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0266282

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0266282, Expressed in female gonad and 35 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VCB8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083958

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 1084SMC_NInterPro annotationAdd BLAST983

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71DisorderedSequence analysisAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili272 – 306Sequence analysisAdd BLAST35
Coiled coili332 – 359Sequence analysisAdd BLAST28
Coiled coili395 – 436Sequence analysisAdd BLAST42
Coiled coili444 – 492Sequence analysisAdd BLAST49
Coiled coili715 – 735Sequence analysisAdd BLAST21
Coiled coili799 – 826Sequence analysisAdd BLAST28
Coiled coili887 – 907Sequence analysisAdd BLAST21
Coiled coili917 – 937Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 71Polar residuesSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0250, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074816

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009063_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCHDHFY

Database of Orthologous Groups

More...
OrthoDBi
263113at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02463, SMC_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VCB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERSRRGRIR RMPSPGSESD GSTAEPTRKR SKQQFVAEAE PDFVEEETEK
60 70 80 90 100
YANASTSQTA RSRNKQARQT TLNMSQRSVN FNLTSELSIP NAFDRCGKVI
110 120 130 140 150
SMRLTNFMCH SNLFIEFGPN INFLVGNNGS GKSAVITALA LGLTSSARAT
160 170 180 190 200
NRASSIQKLI KNGEVSATIS ITLSNSGLRP FKADIFGPHL TVVRQIRHSS
210 220 230 240 250
STYDLQDARG KSVSKKVSDI RRMLLCFGIN VENPIFVLNQ EAAREFLKEL
260 270 280 290 300
EPASNYKLLM KATQLDVCTS SLTECHALRR HFTQELEQLE KKKEMMIKHI
310 320 330 340 350
AAEEEKLSIL EDKEMVKENL QQCKTKLAWM AVTSYQNELN NLEHSIKLIE
360 370 380 390 400
NKKASLEQTT SKKESTQATM NQKLKEFEAS KNQILATQKF QDERLKTAKK
410 420 430 440 450
AVQDLLLEAS QVKAKIGNAE RRMREDQRSY DECEKLIGNY HADFNRVNEQ
460 470 480 490 500
REENANKIEM LKKQVVKSEE IIAQLRAEQQ EIKRDITSVQ ERLDAVKNGR
510 520 530 540 550
IQLHKSKQNI SWEIEALSRN KSNKLSVYGE QTIQVVHALR TQYAGSNMHR
560 570 580 590 600
MPRGPLGQYI SAPNPKYRDL IENQLMHCLR SFIVGSDRER QSLRALLQNK
610 620 630 640 650
FQGGNMPTII TSPFTDRVYD VSRNKVQPTT PNTTVLIDEI SCDDPVVMNY
660 670 680 690 700
LIDILRIETV LVTESKEIAE FLTSDTENVP PNLTRVLVPN LGLEYIPSPN
710 720 730 740 750
YAVYSTRITP ARYIQKNVDD RIRQLQMEQS DLQEKEPSLE IDYMQHKKVL
760 770 780 790 800
ENTQKVISQK STMIGQHQSR NQKAMQKIME LQNFDYQELP EYDRLKSHLA
810 820 830 840 850
DSGEKIEKCR LEREMLQEKL LSIQHRQTEL ESTEAEERRA LEGINKKLTA
860 870 880 890 900
LDTEAGEVES KMRSLDLHYE ENTRRFQKTL QLERKMLGEK ETVLSELEKA
910 920 930 940 950
RTEAEKLGEF IATTQTEEKI REAISRYKSK IKQVEELNYN PEELERGLAE
960 970 980 990 1000
LRDELELQSR HLAVVDSVVK KLRMAYHQRA QLFQRSRHHY FTMVQFQFEQ
1010 1020 1030 1040 1050
ALAMRQFKVS FETSDKEKTW KINVFPPSGN ETSNTRSLSG GERSFTTVSL
1060 1070 1080 1090 1100
LKGLWSTSDH PFYFLDEYDV FTDEVNRKFI TEILIGEGLE WLSRQYCFLT
1110 1120
PQDTKVEASN LITVHKLEAP ER
Length:1,122
Mass (Da):129,335
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFB75F724BB5E3B1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56254.1
BT023747 mRNA Translation: AAZ41755.1

NCBI Reference Sequences

More...
RefSeqi
NP_651228.1, NM_142971.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084573; FBpp0083958; FBgn0266282

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5524

UCSC genome browser

More...
UCSCi
CG5524-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56254.1
BT023747 mRNA Translation: AAZ41755.1
RefSeqiNP_651228.1, NM_142971.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VCB8, 2 interactors
STRINGi7227.FBpp0083958

Genome annotation databases

EnsemblMetazoaiFBtr0084573; FBpp0083958; FBgn0266282
GeneIDi42876
KEGGidme:Dmel_CG5524
UCSCiCG5524-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42876
FlyBaseiFBgn0266282, jnj
VEuPathDBiVectorBase:FBgn0266282

Phylogenomic databases

eggNOGiKOG0250, Eukaryota
GeneTreeiENSGT00550000074816
HOGENOMiCLU_009063_0_0_1
OMAiMCHDHFY
OrthoDBi263113at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42876, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42876

Gene expression databases

BgeeiFBgn0266282, Expressed in female gonad and 35 other tissues

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
PfamiView protein in Pfam
PF02463, SMC_N, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VCB8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VCB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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