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Entry version 156 (11 Dec 2019)
Sequence version 2 (01 Jun 2003)
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Protein

Ankyrin repeat and KH domain-containing protein mask

Gene

mask

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediator of receptor tyrosine kinase (RTK) signaling, and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway (PubMed:11782402). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:26251439).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9VCA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and KH domain-containing protein mask
Alternative name(s):
Multiple ankyrin repeat single KH domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:maskImported
ORF Names:CG33106
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0043884 mask

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit compromised photoreceptor differentiation, cell survival and proliferation (PubMed:11782402). RNAi-mediated knockdown in muscles causes severe lethality at the early pupal stage and the few surviving animals can not fly (PubMed:26251439). Severe defects in the indirect flight muscle structure characterized by narrower myofibrils and abnormal positioning of sarcomere Z line, M line and H line (PubMed:26251439). Although the spacing between Z line and M lines stays regular, M lines are not straight and sarcomere length is shorter. In the more affected myofibrils, the sarcomere structure is lost (PubMed:26251439). Localization of unc-89/obscurin to M lines and localization of kettin (sls isoform A) to Z line is not affected (PubMed:26251439).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003126811 – 4001Ankyrin repeat and KH domain-containing protein maskAdd BLAST4001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei501Phosphoserine2 Publications1
Modified residuei1389Phosphoserine1 Publication1
Modified residuei1588Phosphoserine1 Publication1
Modified residuei2687Phosphoserine1 Publication1
Modified residuei2698Phosphothreonine1 Publication1
Modified residuei2747Phosphoserine1 Publication1
Modified residuei2753Phosphoserine1 Publication1
Modified residuei3596Phosphoserine1 Publication1
Modified residuei3820Phosphoserine1 Publication1
Modified residuei3822Phosphoserine1 Publication1
Modified residuei3825Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VCA8

PRoteomics IDEntifications database

More...
PRIDEi
Q9VCA8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VCA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously in eye imaginal disk, slightly higher expression is seen in presumptive photoreceptors (PubMed:11782402). Expressed in indirect flight muscle (IFM) (at protein level) (PubMed:26251439).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0043884 Expressed in 41 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9VCA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VCA8 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with Unc-89 (via protein kinase domain 1 or 2).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P141302EBI-89853,EBI-114906

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
72524, 29 interactors

Database of interacting proteins

More...
DIPi
DIP-22630N

Protein interaction database and analysis system

More...
IntActi
Q9VCA8, 15 interactors

Molecular INTeraction database

More...
MINTi
Q9VCA8

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293580

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VCA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati546 – 575ANK 1Sequence analysisAdd BLAST30
Repeati584 – 614ANK 2Sequence analysisAdd BLAST31
Repeati618 – 647ANK 3Sequence analysisAdd BLAST30
Repeati651 – 680ANK 4Sequence analysisAdd BLAST30
Repeati684 – 713ANK 5Sequence analysisAdd BLAST30
Repeati718 – 747ANK 6Sequence analysisAdd BLAST30
Repeati751 – 780ANK 7Sequence analysisAdd BLAST30
Repeati784 – 813ANK 8Sequence analysisAdd BLAST30
Repeati817 – 846ANK 9Sequence analysisAdd BLAST30
Repeati851 – 880ANK 10Sequence analysisAdd BLAST30
Repeati881 – 910ANK 11Sequence analysisAdd BLAST30
Repeati914 – 943ANK 12Sequence analysisAdd BLAST30
Repeati947 – 976ANK 13Sequence analysisAdd BLAST30
Repeati981 – 1011ANK 14Sequence analysisAdd BLAST31
Repeati1014 – 1043ANK 15Sequence analysisAdd BLAST30
Repeati2312 – 2341ANK 16Sequence analysisAdd BLAST30
Repeati2345 – 2374ANK 17Sequence analysisAdd BLAST30
Repeati2379 – 2408ANK 18Sequence analysisAdd BLAST30
Repeati2412 – 2441ANK 19Sequence analysisAdd BLAST30
Repeati2447 – 2476ANK 20Sequence analysisAdd BLAST30
Repeati2481 – 2510ANK 21Sequence analysisAdd BLAST30
Repeati2514 – 2543ANK 22Sequence analysisAdd BLAST30
Repeati2549 – 2578ANK 23Sequence analysisAdd BLAST30
Repeati2582 – 2611ANK 24Sequence analysisAdd BLAST30
Repeati2615 – 2644ANK 25Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3036 – 3100KHPROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2674 – 2732Sequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 125Asn-richSequence analysisAdd BLAST88
Compositional biasi96 – 160Thr-richSequence analysisAdd BLAST65
Compositional biasi189 – 354Ala-richSequence analysisAdd BLAST166
Compositional biasi409 – 487Glu-richSequence analysisAdd BLAST79
Compositional biasi1172 – 1275Gln-richSequence analysisAdd BLAST104
Compositional biasi1422 – 1501Ala-richSequence analysisAdd BLAST80
Compositional biasi1649 – 1744Glu-richSequence analysisAdd BLAST96
Compositional biasi1692 – 1760Asp-richSequence analysisAdd BLAST69
Compositional biasi1953 – 2213Gln-richSequence analysisAdd BLAST261
Compositional biasi2737 – 2759Asp-richSequence analysisAdd BLAST23
Compositional biasi2887 – 2938Ser-richSequence analysisAdd BLAST52
Compositional biasi3153 – 3275Ser-richSequence analysisAdd BLAST123
Compositional biasi3278 – 3377Ala-richSequence analysisAdd BLAST100
Compositional biasi3400 – 3458Gln-richSequence analysisAdd BLAST59
Compositional biasi3565 – 3577Gln-richSequence analysisAdd BLAST13
Compositional biasi3650 – 3685Ala-richSequence analysisAdd BLAST36
Compositional biasi3690 – 3718Gln-richSequence analysisAdd BLAST29
Compositional biasi3878 – 3950Gln-richSequence analysisAdd BLAST73

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174194

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9VCA8

KEGG Orthology (KO)

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KOi
K16726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 7 hits
3.30.1370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9VCA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNDAKNHES DDLNVRSTAY FNQQTTTNQP KAPATSKNNT GSGSGSNNNN
60 70 80 90 100
NNTNQNPNRQ LNHNLPRIAA ARQSIAAALL KNSGRKILTA KNEPLTTTES
110 120 130 140 150
SGVLTNTPLP SNSRLKVNNN NNTNNTAKMS GTSSSQSSAT PTPPTASSST
160 170 180 190 200
TTTTTTNIST GGGGSGSSGG GGGSTTVIAN PASVTNTGAG SAAKFRAAVA
210 220 230 240 250
SAPSPALPAT NAPANATAAA AIAAIATAPA PSSSSSSSSS SKKTRAAVAA
260 270 280 290 300
LKRQVALQQQ QPVTGNAPNM TSKDSAHLKF ATTTLLMGAA AAAADSNAGA
310 320 330 340 350
ALGGSGAGGS GSSSSVGAVG GARMALNPAV DMANAAVLLK QKLKDAAAAA
360 370 380 390 400
SASASNRSAT SSMSSTASSL SSSAGIVNAI SSALQNIITP DTDTDTEFYP
410 420 430 440 450
QPVTTDLSES EEESVSEDDI PESDPDSCPH EGEVREDEDE TEEESEDSDE
460 470 480 490 500
SEGEEEEEDE EEIDVLQDND ADDEEIDDED EEEDAPEVSS FLLDANNKRS
510 520 530 540 550
SNISALLEAA ANEKAPVLRH ATHAIDETKQ ALTKMRCASS PRDKNSGFSR
560 570 580 590 600
SLVAACTDND VNTVKRLLCK GNVNLNDAAA STDDGESLLS MACSAGYYEL
610 620 630 640 650
AQVLLAMSAA QVEDKGQKDS TPLMEAASAG HLDIVKLLLN HNADVNAHCA
660 670 680 690 700
TGNTPLMFAC AGGQVDVVKV LLKHGANVEE QNENGHTPLM EAASAGHVEV
710 720 730 740 750
AKVLLEHGAG INTHSNEFKE SALTLACYKG HLDMVRFLLQ AGADQEHKTD
760 770 780 790 800
EMHTALMEAS MDGHVEVARL LLDSGAQVNM PTDSFESPLT LAACGGHVEL
810 820 830 840 850
ATLLIERGAN IEEVNDEGYT PLMEAAREGH EEMVALLLSK GANINATTEE
860 870 880 890 900
TQETALTLAC CGGFMEVAAF LIKEGANLEL GASTPLMEAS QEGHTDLVSF
910 920 930 940 950
LLKKKANVHA ETQTGDTALT HACENGHTDA AGVLLSYGAE LEHESEGGRT
960 970 980 990 1000
PLMKACRAGH LCTVKFLIQK GANVNKQTTS NDHTALSLAC AGGHQSVVEL
1010 1020 1030 1040 1050
LLKNNADPFH KLKDNSTMLI EASKGGHTRV VELLFRYPNI SPTENAASAN
1060 1070 1080 1090 1100
VTQAAPTSNQ PGPNQMRQKI MKQQLQHQLQ QLNAPPGLHE LSEAARASNQ
1110 1120 1130 1140 1150
QHFHQQQFSS AGNGSSNIVA MGTGDFLDAG ELQLTATAGM SAGAGTSTTG
1160 1170 1180 1190 1200
SETGMEEYGE VGGIDLTTLG AQQQEGLIAK SRLFHLQQQQ QQQQQQQQQQ
1210 1220 1230 1240 1250
QQQQQQQQQQ QQQQQQPPAA GQHQLVPCKH FDLDMEHINS LQPPQKAPPA
1260 1270 1280 1290 1300
PPVLFHTVCQ QPVMQQQQQQ LQPGQLKLKA MLPNRNRALK TAEVVEFIDC
1310 1320 1330 1340 1350
PVDQQQPGEQ VRTQPLGEDG KTPQFACAGE DPRLQRRRGF MPELKKGELP
1360 1370 1380 1390 1400
PESSSSDPNE LALKGADNNQ PVPTALDNSA CAQIPARNSG GAITHSSEVL
1410 1420 1430 1440 1450
QSTAISDRPK VKATNKNNRK QAAAAAAAAA AAAAAAAAAA QHAQQVLPNP
1460 1470 1480 1490 1500
MVSIYNNLHL QHLQHPHLQF QQQLQLHHQR VAGLDNAAAA AAAAASSANM
1510 1520 1530 1540 1550
AYSISPASPL PSPTGSGNYV DQQLQQQSMD VALQRKTAMD DFRGMLETAV
1560 1570 1580 1590 1600
NGPRGRKDLA LNTPQLNFFK DGWHMVGVHN FFGDQPKSPT ETPPEMEETT
1610 1620 1630 1640 1650
MSSPTEADRL GSEPRAEMKN LATLCSAAAA AAAVAAVNKD QVEISSDLES
1660 1670 1680 1690 1700
ECEDDAEGGA GADCEENTLP PEPIELAAAL REDGIIVEEE EDDEEEDDDD
1710 1720 1730 1740 1750
EEQDTNSGEV DKLNYDDEDA EVDNDGEVDY IDEDEGGGEG EEEEDDADDD
1760 1770 1780 1790 1800
EFFLDEPDSD QGTGNNNNNS KSGASSLPLK QRKMATRLEN LILNSQTVCD
1810 1820 1830 1840 1850
FPPELSNSEL VHVLPQISNL KAAANSNAAL NSVLQQQLAA ASAAAAHAKA
1860 1870 1880 1890 1900
SVVHQKQQHG EGDQQCEDDG SASASELYSG LEHFANDGEM EDIFQELASS
1910 1920 1930 1940 1950
LNYPELAEFS LNQMCKGRFA GNWAQSSGKW TGQEQLVGVV RSPGLINPGD
1960 1970 1980 1990 2000
VPQDAQRQAN LVLLDYPMQQ NIQLEQRLLD AEEMHLQQHQ QTPLSLLPFT
2010 2020 2030 2040 2050
DEQQQQLHHQ ALSNASDFQQ HQQLALENDP ELKQQLQQNS NARIIKAVAA
2060 2070 2080 2090 2100
QHQQQPPTNF VYNVESGDKN APPVQLLFQL PPHMAQHQAQ QQQGVGEPLT
2110 2120 2130 2140 2150
EQQQQQLHAE QAHLFQHRTG GQRPPTQSEL EQVAQELLLQ RSGQVPAGAP
2160 2170 2180 2190 2200
VVGVQAIPLK QKHFNLHPPP CPPTCVQHQV ATQTHPASVV VPQPAVGYTQ
2210 2220 2230 2240 2250
FALQASQQQQ MQQNELSIWP MATPTPAPSS GVSSTKSMPG GIAKKAIDKQ
2260 2270 2280 2290 2300
SRKERRCVVR QTPAGIQENT KLHLQPQVAT AQQQFLVQNQ LAVATTVSLD
2310 2320 2330 2340 2350
KTIEIDSETE SNHDTALTLA CAGGHEELVE LLINRGANIE HRDKKGFTPL
2360 2370 2380 2390 2400
ILAATAGHDK VVDILLKHSA ELEAQSERTK DTPLSLACSG GRYEVVELLL
2410 2420 2430 2440 2450
SVGANKEHRN VSDYTPLSLA ASGGYVNIIK LLLSHGAEIN SRTGSKLGIS
2460 2470 2480 2490 2500
PLMLAAMNGH TPAVKLLLDQ GSDINAQIET NRNTALTLAC FQGRHEVVSL
2510 2520 2530 2540 2550
LLDRRANVEH RAKTGLTPLM EAASGGYIEV GRVLLDKGAD VNAAPVPTSR
2560 2570 2580 2590 2600
DTALTIAADK GHQKFVELLL SRNASVEVKN KKGNSPLWLA AHGGHLSVVE
2610 2620 2630 2640 2650
LLYDHNADID SQDNRRVSCL MAAFRKGHTK IVKWMVQYVS QFPSDQEMIR
2660 2670 2680 2690 2700
FIGTISDKEL IDKCFDCMKI LRSAKEAQAV KANKNASILL EELDLERTRE
2710 2720 2730 2740 2750
ESRKAAAARR RERKKKKKME KKEEKRRQQQ GNGPGGDDMQ GDDDDASDKD
2760 2770 2780 2790 2800
DDSDKDDEDE EAAPAAAREE GDSGIDQGSC SSGDTKGARF GGSQSAQAAE
2810 2820 2830 2840 2850
AAANSVSTNS QGKKNKKQAK NKVLISVEPT QPVITSNSVL KGVCAKKHPA
2860 2870 2880 2890 2900
VEVVKQPPAT QQAAPLKRQL DVKKEEPALK KKEEKNSSSS SSSKREKENL
2910 2920 2930 2940 2950
APKEVALPAK QQPSSSSKLQ SSESASNINS STATNTSSAN TTRKEVAKPA
2960 2970 2980 2990 3000
SQTASATTLN PAKRTEVDGW KEVVRKSSAQ QTTAVGASGA PLPVTATSSA
3010 3020 3030 3040 3050
TSVQHHPHHH LANSSSNSSS SLTTSTTTAA SSVPEMTCKK VQVPVNAISR
3060 3070 3080 3090 3100
VIGRGGSNIN AIRATTGAHI EVEKQGKNQS ERCITIKGLT DATKQAHMLI
3110 3120 3130 3140 3150
LALIKDPDVD ILQMLPRINS SIKQASSGGA STPMSVGTWD NRTAAGVNAY
3160 3170 3180 3190 3200
TFSSAASTTS TSSSSSASST TPAGASYSNA HKQHQQQPQS VKGPSGRSST
3210 3220 3230 3240 3250
SVKSNGSSTK VSASSGSGSR SGRAGSSYLA QQQPGRSSGG GSSNGVIKSK
3260 3270 3280 3290 3300
SESSSKSLPA AQKSSTTLGK SSTVSPGAQN FAKAAAIGQS SPKKAEGGAT
3310 3320 3330 3340 3350
SAVVTSAGGR SSGVVAPFGR GKPVAGQGGP AATAASNVAQ LGSVSGNSNI
3360 3370 3380 3390 3400
LAGPIGTFNV ADVAAVNAAA AAGAAAATNS NVKPIAPIAP PSKRVGSPTQ
3410 3420 3430 3440 3450
VQQQHQTQQQ QQQQLPQPAP VPGPQPQQQP LQQQQQQQAP QQQPQQPNQQ
3460 3470 3480 3490 3500
QQPQTSQQNL VINTNLLNDL MAASAANTTS DSFSAQLAAK LSSAYSLFSD
3510 3520 3530 3540 3550
YQQSQWGKLG DPGIGGGAGA VGDGLPQADA SKAPGYNRNI LSSPVGSSKA
3560 3570 3580 3590 3600
SSNHSTSPPV GNVIQQQQQQ QPQSSQQALN IITSGPGGPA TAPARSPMVS
3610 3620 3630 3640 3650
ANEGNPAVGQ PSMNGTQGLG ETAPAHSPGV IKPPTATVPI QRHVPMPISA
3660 3670 3680 3690 3700
PEAGAPPTFG AIGSNPASGN NSAAAQAAAA AAASAMIDRQ QQNLQNLQTL
3710 3720 3730 3740 3750
QNLQRMVGAS QQQQPQQQLN YPMDPTSSFI VDANNVLRLN PRVIFPQGNT
3760 3770 3780 3790 3800
KPPQPPPQGG TQSNVFGGNP GRQPPGTGAR QPGGAAAQRW YGGTLEYPSY
3810 3820 3830 3840 3850
TGRDMLHLEN GAGGMAGMGS PSAMSPNHDD IRKMPRPIGT ERAASWKYNN
3860 3870 3880 3890 3900
FNVGGPSLNM EDALASVLPP WAHELKAQPP GLQQPPPPPQ SQQQQQQPLN
3910 3920 3930 3940 3950
WLKQQPQQQQ YRAYNNGPYP QQQQQHEPMN MPMDYHNMQA PPNMSQQQQQ
3960 3970 3980 3990 4000
HVNLMPSYGY QHFVGAPGAV DISAHMPDKM EVWDHHDKHM PWTNYTTNWS

N
Length:4,001
Mass (Da):423,201
Last modified:June 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22335427E9C8D447
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KHZ8A0A0B4KHZ8_DROME
Multiple ankyrin repeats single KH ...
mask CG18671, CG31138, CG6268, CG6313, cg6313
3,636Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K725A0A0B4K725_DROME
Multiple ankyrin repeats single KH ...
mask CG18671, CG31138, CG6268, CG6313, cg6313
4,010Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LHK4A0A0B4LHK4_DROME
Multiple ankyrin repeats single KH ...
mask CG18671, CG31138, CG6268, CG6313, cg6313
3,623Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHR8A0A0B4KHR8_DROME
Multiple ankyrin repeats single KH ...
mask CG18671, CG31138, CG6268, CG6313, cg6313
4,000Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39468 differs from that shown. Reason: Frameshift.Curated
The sequence AAL39468 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL68383 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM11086 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2886N → T in AAL65911 (PubMed:11782402).Curated1
Sequence conflicti3307A → G in AAL68383 (PubMed:12537569).Curated1
Sequence conflicti3401V → A in AAL68383 (PubMed:12537569).Curated1
Sequence conflicti3408Q → H in AAR82779 (Ref. 4) Curated1
Sequence conflicti3415L → Q in AAR82779 (Ref. 4) Curated1
Sequence conflicti3430 – 3431PL → QPHQQQ in AAL68383 (PubMed:12537569).Curated2
Sequence conflicti3474S → N in AAL68383 (PubMed:12537569).Curated1
Sequence conflicti3578A → V in AAL68383 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF425651 mRNA Translation: AAL65911.1
AE014297 Genomic DNA Translation: AAO41600.1
AE014297 Genomic DNA Translation: AAO41601.1
BT011112 mRNA Translation: AAR82779.1
AY069323 mRNA Translation: AAL39468.1 Sequence problems.
AY075578 mRNA Translation: AAL68383.1 Different initiation.
AY094733 mRNA Translation: AAM11086.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_788733.1, NM_176556.2
NP_788734.1, NM_176557.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084562; FBpp0083947; FBgn0043884
FBtr0084563; FBpp0083948; FBgn0043884

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33106

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425651 mRNA Translation: AAL65911.1
AE014297 Genomic DNA Translation: AAO41600.1
AE014297 Genomic DNA Translation: AAO41601.1
BT011112 mRNA Translation: AAR82779.1
AY069323 mRNA Translation: AAL39468.1 Sequence problems.
AY075578 mRNA Translation: AAL68383.1 Different initiation.
AY094733 mRNA Translation: AAM11086.1 Different initiation.
RefSeqiNP_788733.1, NM_176556.2
NP_788734.1, NM_176557.2

3D structure databases

SMRiQ9VCA8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi72524, 29 interactors
DIPiDIP-22630N
IntActiQ9VCA8, 15 interactors
MINTiQ9VCA8
STRINGi7227.FBpp0293580

PTM databases

iPTMnetiQ9VCA8

Proteomic databases

PaxDbiQ9VCA8
PRIDEiQ9VCA8

Genome annotation databases

EnsemblMetazoaiFBtr0084562; FBpp0083947; FBgn0043884
FBtr0084563; FBpp0083948; FBgn0043884
GeneIDi50070
KEGGidme:Dmel_CG33106

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50070
FlyBaseiFBgn0043884 mask

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000174194
InParanoidiQ9VCA8
KOiK16726

Enzyme and pathway databases

SignaLinkiQ9VCA8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
mask fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50070

Protein Ontology

More...
PROi
PR:Q9VCA8

Gene expression databases

BgeeiFBgn0043884 Expressed in 41 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9VCA8 baseline and differential
GenevisibleiQ9VCA8 DM

Family and domain databases

Gene3Di1.25.40.20, 7 hits
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit
SUPFAMiSSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANKHM_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VCA8
Secondary accession number(s): Q6NP19
, Q8SX96, Q8T0H2, Q8T8Q4, Q8WRQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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