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Entry version 161 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Dis3, isoform A

Gene

Dis3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, RNA-bindingARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-429958, mRNA decay by 3' to 5' exoribonuclease
R-DME-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DME-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dis3, isoform AImported (EC:3.1.13.-Imported)
Submitted name:
Dis3, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dis3Imported
Synonyms:dDis3Imported, dis3Imported, Dmel\CG6413Imported, dRrp44Imported, Rrp44Imported, TazImported, tazImported
ORF Names:CG6413Imported, Dmel_CG6413Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0039183, Dis3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0039183

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

ExosomeARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VC93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0039183, Expressed in embryo and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VC93, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VC93, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083989

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VC93

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 188PINcInterPro annotationAdd BLAST127
Domaini474 – 806RNBInterPro annotationAdd BLAST333

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni958 – 982DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili597 – 617Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2102, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002333_5_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQYKPFP

Database of Orthologous Groups

More...
OrthoDBi
1104619at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VC93

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041505, Dis3_CSD2
IPR012340, NA-bd_OB-fold
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1
IPR033770, RRP44_S1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17849, OB_Dis3, 1 hit
PF13638, PIN_4, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit
PF17215, Rrp44_S1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00670, PINc, 1 hit
SM00955, RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 3 hits
SSF88723, SSF88723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VC93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTLREFTRK TKRGNILKIV REHYLRDDIG CGSELCRECF QNEVYQLTSQ
60 70 80 90 100
HANKSTLFKF PHYLVLDTNV VLDQIDVLEE DVLRNVVVLT TVLNEVKHRS
110 120 130 140 150
SAIYKRFNEI VHDRTRNFYV FVNEHHKETY ADREPDETAN DRNDRAIRLA
160 170 180 190 200
TKWYDDHLQA SQSSKEFERS GKAATRVVLL TDDAANRAKA EAEGILVTTA
210 220 230 240 250
AEYVKSLEDF PLLMDKLSHK TFDSEKNGLP QYPPHLSMKE LLEGLRQNKL
260 270 280 290 300
LQGTFQASRE NYLEGTVNVE KFEKGILIQG RESLNRAVDG DLVAVELLPE
310 320 330 340 350
AEWSAPSEIV LEEKNVYADE VPSEERAKDE NEMLNQVRAA ALSAERTPTG
360 370 380 390 400
RIVGIVRRKW RQYCGILQPS LIEDTNRHIF VPADRKIPRI RIETRQAAML
410 420 430 440 450
QNQRIIVTID TWPRNSRYPH GHFVRSLGPL GDMATENEVI LLEHDVPHCK
460 470 480 490 500
FSDEVLSFLP KMPWTITDED YSKRVDLRDL YICSVDPPGC TDIDDALHCK
510 520 530 540 550
ELPNGNLEVG VHIADVSHFI RPGNALDMEA AARGTTVYLV GKRIDMVPEL
560 570 580 590 600
LSSNLCSLVG GVERFAFSCV WEVDNEANVL SKRFHKSVIK SKRAMTYEEA
610 620 630 640 650
QNIIDDATQQ NEIAKSLRNL NRLAKILKKR RMDNGALVLA SPEIRFQVDS
660 670 680 690 700
ETHEPLEVEV KQMRETNSMV EEFMLLANIT VAEHIATEFS ECAVLRRHPR
710 720 730 740 750
PPPTNFDPLV KSARYQGFQV DINSGLELSH SLDKCVKADN PYFNTMIRIL
760 770 780 790 800
TTRCMMQAVY FISGSLQKEE FFHYGLAAPI YTHFTSPIRR YSDIMVHRLL
810 820 830 840 850
AASIGADSTY AQLLDRKSNE ELCHNLNYRH KMAQYAGRAS VALNTHLFFR
860 870 880 890 900
GKEEDEEGYV LFVRKNALQV LIPKYGLEGT LYLKSDKDGK DGVERVKSEI
910 920 930 940 950
VFTFNEEDHT QRCGDVVFHS FDPVTVRLSL DSSNVQHEKL IFRLVKPYIK
960 970 980
GFSVETTTEG TDSQAVSAAP PSKKTKKDKK KK
Length:982
Mass (Da):112,183
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C55A04867611FF4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56281.1
AE014297 Genomic DNA Translation: AGB96290.1

NCBI Reference Sequences

More...
RefSeqi
NP_001262910.1, NM_001275981.1
NP_651246.2, NM_142989.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084605; FBpp0083989; FBgn0039183
FBtr0334599; FBpp0306666; FBgn0039183

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6413

UCSC genome browser

More...
UCSCi
CG6413-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56281.1
AE014297 Genomic DNA Translation: AGB96290.1
RefSeqiNP_001262910.1, NM_001275981.1
NP_651246.2, NM_142989.4

3D structure databases

SMRiQ9VC93
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VC93, 8 interactors
STRINGi7227.FBpp0083989

Proteomic databases

PRIDEiQ9VC93

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9VC93, 1 sequenced antibody

Genome annotation databases

EnsemblMetazoaiFBtr0084605; FBpp0083989; FBgn0039183
FBtr0334599; FBpp0306666; FBgn0039183
GeneIDi42900
KEGGidme:Dmel_CG6413
UCSCiCG6413-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22894
FlyBaseiFBgn0039183, Dis3
VEuPathDBiVectorBase:FBgn0039183

Phylogenomic databases

eggNOGiKOG2102, Eukaryota
GeneTreeiENSGT00530000063106
HOGENOMiCLU_002333_5_0_1
OMAiVQYKPFP
OrthoDBi1104619at2759
PhylomeDBiQ9VC93

Enzyme and pathway databases

ReactomeiR-DME-429958, mRNA decay by 3' to 5' exoribonuclease
R-DME-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DME-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42900, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42900

Gene expression databases

BgeeiFBgn0039183, Expressed in embryo and 26 other tissues
ExpressionAtlasiQ9VC93, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR041505, Dis3_CSD2
IPR012340, NA-bd_OB-fold
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1
IPR033770, RRP44_S1
PfamiView protein in Pfam
PF17849, OB_Dis3, 1 hit
PF13638, PIN_4, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit
PF17215, Rrp44_S1, 1 hit
SMARTiView protein in SMART
SM00670, PINc, 1 hit
SM00955, RNB, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF88723, SSF88723, 1 hit
PROSITEiView protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VC93_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VC93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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