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UniProtKB - Q9VBH3 (Q9VBH3_DROME)

Entry version 170 (07 Oct 2020)
Sequence version 4 (30 Nov 2010)
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Protein
Submitted name:

Dysfusion, isoform D

Gene

dysf

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dysfusion, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dysfImported
Synonyms:CG12561Imported, CG14552Imported, CG14553Imported, CG14554Imported, Dmel\CG32474Imported, dNXFLImported, DysImported, dysImported, DYSFImported, DysfImported, NXFLImported
ORF Names:CG32474Imported, Dmel_CG32474Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0039411, dysf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VBH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0039411, Expressed in embryonic leading edge cell (Drosophila) and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VBH3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VBH3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VBH3, 4 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0289845

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VBH3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 205BHLHInterPro annotationAdd BLAST54
Domaini234 – 297PASInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 145DisorderedSequence analysisAdd BLAST91
Regioni291 – 333DisorderedSequence analysisAdd BLAST43
Regioni551 – 612DisorderedSequence analysisAdd BLAST62
Regioni647 – 675DisorderedSequence analysisAdd BLAST29
Regioni821 – 849DisorderedSequence analysisAdd BLAST29
Regioni861 – 883DisorderedSequence analysisAdd BLAST23
Regioni898 – 920DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 95PolarSequence analysisAdd BLAST41
Compositional biasi105 – 145PolarSequence analysisAdd BLAST41
Compositional biasi291 – 308PolarSequence analysisAdd BLAST18
Compositional biasi555 – 569PolarSequence analysisAdd BLAST15
Compositional biasi585 – 608BasicSequence analysisAdd BLAST24
Compositional biasi655 – 669Pro-richSequence analysisAdd BLAST15
Compositional biasi824 – 849PolarSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRXX, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064165

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VBH3

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VBH3

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR000014, PAS
IPR035965, PAS-like_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55785, SSF55785, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VBH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNAIGASSI TKWISQIESF EQRELVTNIC KRAIDDMYAD NKRGLDKVTA 
        60         70         80         90        100
ATPPTHALQQ QQQQQHPHQQ QQHLQHVLQL QQQQQQHLQQ QQHHLQHQMH 
       110        120        130        140        150
THHNFQQHET SPTVSQQQHM QQQQPQTTQQ QHATQQQQQQ QQQTAGMFTR 
       160        170        180        190        200
FDANKSTKGA SKMRRDLINA EIANLRDLLP LPQSTRQRLS QLQLMALVCV 
       210        220        230        240        250
YVRKANYFQQ VFKRHNAMHH LHHQTATPNI GFSKALSGFL MMLTQNGKLL 
       260        270        280        290        300
YISDNAAEYL GHSMEDLLIH GDSVYDIIDK QDHANIQAEL NRNVPPQPGG 
       310        320        330        340        350
SSQASSGGAG GAGGAGDSTS SNGSAAGAGG AGGASSLEGE HRMFLCRMNV 
       360        370        380        390        400
SRNARRQMRF GDQKVVLVQG HYLSFLPLCS RNEPVFLATC TPIAMPETRE 
       410        420        430        440        450
CVVQGATNVF TTIHSMDMKI AHIDKNGEFH LGYDKSTLQG TSWYNLIHSD 
       460        470        480        490        500
NLTEAQKKHS LIIQSEQDRS CILLVRMQRS SGEYTWVHVV LQVRDSPDST 
       510        520        530        540        550
QQPVIVCTNQ VLNDREASIM LANSWLYHYY TVQSKIQFGM PLDSGIRVPP 
       560        570        580        590        600
GTPSSGYYSP HSSHPPATPG GATPNLGIAS SFGPHHHPHH SHHPHHHHHH 
       610        620        630        640        650
HHPATAYHHH PHMGTYGGVY HAKAAIELKE DQPLFCFQEP VDYSQVNSHV 
       660        670        680        690        700
NPPNATSTPN PPISKSSTPP PPKKRARKLE PLYLHAERSP AAAITPEPDC 
       710        720        730        740        750
YAIHTHPAAA YATSSVVSSD ASVIYATIVP TRPRLPNKSL PPDPADFIEQ 
       760        770        780        790        800
WNPSPPWSES AQKASLDSFG SSHELSPCIT TTPPTPTSAT PHQSGLGTTQ 
       810        820        830        840        850
TIGPAFSFEW MSDPLVPVTY QQWPPTGDHH QHLSQHLSQS QNHQNPLQQQ 
       860        870        880        890        900
QNEQLLLGQQ PHLHQQHQHL ALHHGRGEHS LEGESQGVVV VPPIPISIPI 
       910        920
PTATGHGDAG EPVEDRDPKN
Length:920
Mass (Da):102,031
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8CEFB8CD018024A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JRD4A8JRD4_DROME
Dysfusion, isoform B
dysf CG12561, CG14552, CG14553, CG14554, Dmel\CG32474
884Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JRD5A8JRD5_DROME
Dysfusion, isoform C
dysf CG12561, CG14552, CG14553, CG14554, Dmel\CG32474
917Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56569.4

NCBI Reference Sequences

More...RefSeqi		NP_733137.3, NM_170258.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0300618; FBpp0289845; FBgn0039411

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43174

UCSC genome browser

More...UCSCi		CG32474-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56569.4
RefSeqiNP_733137.3, NM_170258.4

3D structure databases

SMRiQ9VBH3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VBH3, 4 interactors
STRINGi7227.FBpp0289845

Proteomic databases

PaxDbiQ9VBH3

Genome annotation databases

EnsemblMetazoaiFBtr0300618; FBpp0289845; FBgn0039411
GeneIDi43174
UCSCiCG32474-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8291
FlyBaseiFBgn0039411, dysf

Phylogenomic databases

eggNOGiENOG502QRXX, Eukaryota
GeneTreeiENSGT00530000064165
InParanoidiQ9VBH3
PhylomeDBiQ9VBH3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		43174, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43174

Gene expression databases

BgeeiFBgn0039411, Expressed in embryonic leading edge cell (Drosophila) and 35 other tissues
ExpressionAtlasiQ9VBH3, baseline and differential
GenevisibleiQ9VBH3, DM

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR000014, PAS
IPR035965, PAS-like_dom_sf
SMARTiView protein in SMART
SM00091, PAS, 2 hits
SUPFAMiSSF55785, SSF55785, 2 hits
TIGRFAMsiTIGR00229, sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VBH3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VBH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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