LD33695p

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase regulator activity Source: InterPro
• protein domain specific binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation."
    Wee B., Johnston C.A., Prehoda K.E., Doe C.Q.
    J Cell Biol 195:369-376(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• asymmetric cell division Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts."
    Januschke J., Gonzalez C.
    J Cell Biol 188:693-706(2010) [PubMed] [Europe PMC] [Abstract]
• asymmetric neuroblast division Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions."
    Cai Y., Yu F., Lin S., Chia W., Yang X.
    Cell 112:51-62(2003) [PubMed] [Europe PMC] [Abstract]
  • "The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division."
    Bonaccorsi S., Mottier V., Giansanti M.G., Bolkan B.J., Williams B., Goldberg M.L., Gatti M.
    Development 134:2183-2193(2007) [PubMed] [Europe PMC] [Abstract]
• asymmetric protein localization involved in cell fate determination Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Mechanisms of spindle positioning: focus on flies and worms."
    Gonczy P.
    Trends Cell Biol 12:332-339(2002) [PubMed] [Europe PMC] [Abstract]
• basal protein localization Source: FlyBaseTraceable author statementⁱ
  • "The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts."
    Peng C.Y., Manning L., Albertson R., Doe C.Q.
    Nature 408:596-600(2000) [PubMed] [Europe PMC] [Abstract]
• establishment of mitotic spindle orientation Source: FlyBaseInferred from direct assayⁱ
  • "Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation."
    Wee B., Johnston C.A., Prehoda K.E., Doe C.Q.
    J Cell Biol 195:369-376(2011) [PubMed] [Europe PMC] [Abstract]
• establishment of spindle orientation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts."
    Siegrist S.E., Doe C.Q.
    Cell 123:1323-1335(2005) [PubMed] [Europe PMC] [Abstract]
• neuroblast proliferation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster."
    Caussinus E., Gonzalez C.
    Nat Genet 37:1125-1129(2005) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein domain specific binding Source: FlyBaseInferred from physical interactionⁱ
  • "Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation."
    Wee B., Johnston C.A., Prehoda K.E., Doe C.Q.
    J Cell Biol 195:369-376(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSLSASAEN VSSLGLGSGG GGTTSHDGNS QQGSGSDGGS SMCLELALEG 
        60         70         80         90        100
ERLCKAGDCR AGVAFFQAAI QAGTEDLRTL SAIYSQLGNA YFYLGDYNKA 
       110        120        130        140        150
MQYHKHDLTL AKSMNDRLGE AKSSGNLGNT LKVMGRFDEA AICCERHLTL 
       160        170        180        190        200
ARQLGDRLSE GRALYNLGNV YHAKGKHLGQ RNPGKFGDDV KEALTRAVEF 
       210        220        230        240        250
YQENLKLMRD LGDRGAQGRA CGNLGNTYYL LGDFQAAIEH HQERLRIARE 
       260        270        280        290        300
FGDRAAERRA NSNLGNSHIF LGQFEDAAEH YKRTLALAVE LGEREVEAQS 
       310        320        330        340        350
CYSLGNTYTL LHEFNTAIEY HNRHLAIAQE LGDRIGEARA CWSLGNAHSA 
       360        370        380        390        400
IGGHERALKY AEQHLQLAKE LHDPVGESTA RVNISDLRKL LGMPDSEPSP 
       410        420        430        440        450
TEEEARSTAS DHSASGNQSD GSENSQGRMV RVRRQSMEQL DLIKITPDGK 
       460        470        480        490        500
RMQEEKLRAQ ATRKAKDDDF FEMLSRSQSK RMDDQRCSIK VNPAGAPAVA 
       510        520        530        540        550
TGATRKPLVQ QNSLFVDPTN LPGLKSPSSA NPSAIGHGPL ARSATTTQQP 
       560        570        580        590        600
DDDFLDMLMR CQGSRLEEQR SELPRPNVTM DAEAEAPPRS VPEAAVPGAP 
       610        620        630        640        650
RGQTGRGATV PDEDFFSLIM KVQSGRMEDQ RASIPFRNAN NNNNSRSNNN 

GSAGGAGK                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ