UniProtKB - Q9VB22 (Q9VB22_DROME)
Protein
Submitted name:
LD33695p
Gene
pins
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- GTPase regulator activity Source: InterPro
- protein domain specific binding Source: FlyBase
GO - Biological processi
- asymmetric cell division Source: FlyBase
- asymmetric neuroblast division Source: FlyBase
- asymmetric protein localization involved in cell fate determination Source: FlyBase
- basal protein localization Source: FlyBase
- establishment of mitotic spindle orientation Source: FlyBase
- establishment of spindle orientation Source: FlyBase
- neuroblast proliferation Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Submitted name: LD33695pImportedSubmitted name: Partner of inscuteableImportedSubmitted name: Pins proteinImportedSubmitted name: RE22964pImported |
Gene namesi | Name:pinsImported Synonyms:dLGNImported, Dmel\CG5692Imported, dPinsImported, PINSImported, PinsImported, RadImported, radImported, RAPSImported, RapsImported, rapsImported, rapsynImported ORF Names:CG5692Imported, Dmel_CG5692Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0040080, pins |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- apical cortex Source: FlyBase
- cell cortex Source: FlyBase
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneInteractioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- protein domain specific binding Source: FlyBase
Protein-protein interaction databases
ComplexPortali | CPX-3174, raps-insc complex |
DIPi | DIP-18320N |
IntActi | Q9VB22, 12 interactors |
STRINGi | 7227.FBpp0084559 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 371 | TPR_REGIONInterPro annotationAdd BLAST | 291 | |
Repeati | 81 – 114 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 218 – 251 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 258 – 291 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 298 – 331 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 338 – 371 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 387 – 437 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 527 – 550 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 566 – 612 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 625 – 658 | DisorderedSequence analysisAdd BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 191 – 211 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 410 – 432 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 634 – 658 | PolarSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the GPSM family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1130, Eukaryota |
GeneTreei | ENSGT00940000154667 |
HOGENOMi | CLU_012445_1_0_1 |
OMAi | AKLHFVN |
OrthoDBi | 733786at2759 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR003109, GoLoco_motif IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02188, GoLoco, 3 hits PF13176, TPR_7, 1 hit |
SMARTi | View protein in SMART SM00390, GoLoco, 3 hits SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50877, GOLOCO, 3 hits PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VB22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSLSASAEN VSSLGLGSGG GGTTSHDGNS QQGSGSDGGS SMCLELALEG
60 70 80 90 100
ERLCKAGDCR AGVAFFQAAI QAGTEDLRTL SAIYSQLGNA YFYLGDYNKA
110 120 130 140 150
MQYHKHDLTL AKSMNDRLGE AKSSGNLGNT LKVMGRFDEA AICCERHLTL
160 170 180 190 200
ARQLGDRLSE GRALYNLGNV YHAKGKHLGQ RNPGKFGDDV KEALTRAVEF
210 220 230 240 250
YQENLKLMRD LGDRGAQGRA CGNLGNTYYL LGDFQAAIEH HQERLRIARE
260 270 280 290 300
FGDRAAERRA NSNLGNSHIF LGQFEDAAEH YKRTLALAVE LGEREVEAQS
310 320 330 340 350
CYSLGNTYTL LHEFNTAIEY HNRHLAIAQE LGDRIGEARA CWSLGNAHSA
360 370 380 390 400
IGGHERALKY AEQHLQLAKE LHDPVGESTA RVNISDLRKL LGMPDSEPSP
410 420 430 440 450
TEEEARSTAS DHSASGNQSD GSENSQGRMV RVRRQSMEQL DLIKITPDGK
460 470 480 490 500
RMQEEKLRAQ ATRKAKDDDF FEMLSRSQSK RMDDQRCSIK VNPAGAPAVA
510 520 530 540 550
TGATRKPLVQ QNSLFVDPTN LPGLKSPSSA NPSAIGHGPL ARSATTTQQP
560 570 580 590 600
DDDFLDMLMR CQGSRLEEQR SELPRPNVTM DAEAEAPPRS VPEAAVPGAP
610 620 630 640 650
RGQTGRGATV PDEDFFSLIM KVQSGRMEDQ RASIPFRNAN NNNNSRSNNN
GSAGGAGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56721.1 AF242203 mRNA Translation: AAF64499.1 AY094817 mRNA Translation: AAM11170.1 BT003523 mRNA Translation: AAO39527.1 |
RefSeqi | NP_524999.2, NM_080260.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0085189; FBpp0084559; FBgn0040080 |
GeneIDi | 53569 |
KEGGi | dme:Dmel_CG5692 |
UCSCi | CG5692-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56721.1 AF242203 mRNA Translation: AAF64499.1 AY094817 mRNA Translation: AAM11170.1 BT003523 mRNA Translation: AAO39527.1 |
RefSeqi | NP_524999.2, NM_080260.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3TVT | X-ray | 1.60 | B | 411-460 | [»] | |
4A1S | X-ray | 2.10 | A/B | 1-368 | [»] | |
5A7D | X-ray | 3.40 | B/C/D/E/F/G/H/I | 25-406 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3174, raps-insc complex |
DIPi | DIP-18320N |
IntActi | Q9VB22, 12 interactors |
STRINGi | 7227.FBpp0084559 |
Genome annotation databases
EnsemblMetazoai | FBtr0085189; FBpp0084559; FBgn0040080 |
GeneIDi | 53569 |
KEGGi | dme:Dmel_CG5692 |
UCSCi | CG5692-RA, d. melanogaster |
Organism-specific databases
CTDi | 53569 |
FlyBasei | FBgn0040080, pins |
Phylogenomic databases
eggNOGi | KOG1130, Eukaryota |
GeneTreei | ENSGT00940000154667 |
HOGENOMi | CLU_012445_1_0_1 |
OMAi | AKLHFVN |
OrthoDBi | 733786at2759 |
Enzyme and pathway databases
Reactomei | R-DME-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 53569, 0 hits in 3 CRISPR screens |
ChiTaRSi | pins, fly |
GenomeRNAii | 53569 |
Gene expression databases
Bgeei | FBgn0040080, Expressed in embryo and 44 other tissues |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR003109, GoLoco_motif IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02188, GoLoco, 3 hits PF13176, TPR_7, 1 hit |
SMARTi | View protein in SMART SM00390, GoLoco, 3 hits SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50877, GOLOCO, 3 hits PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VB22_DROME | |
Accessioni | Q9VB22Primary (citable) accession number: Q9VB22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |