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UniProtKB - Q9VB18 (Q9VB18_DROME)

Entry version 166 (10 Feb 2021)
Sequence version 4 (01 Apr 2015)
Previous versions | rss
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Protein
Submitted name:

FI16909p1

Gene

Tusp

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI16909p1Imported
Submitted name:
Tusp, isoform DImported
Submitted name:
Tusp, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TuspImported
Synonyms:Dmel\CG5586Imported, DMG2-MB6.chr3R.24.043Imported, TUSPImported, Tusp-RDImported
ORF Names:CG5586Imported, Dmel_CG5586Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0039530, Tusp

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0039530, Expressed in head and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VB18, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0291746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 207WD_REPEATS_REGIONInterPro annotationAdd BLAST127
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 112WDPROSITE-ProRule annotationAdd BLAST32
Domaini360 – 410SOCS boxInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni503 – 568DisorderedSequence analysisAdd BLAST66
Regioni682 – 785DisorderedSequence analysisAdd BLAST104
Regioni984 – 1015DisorderedSequence analysisAdd BLAST32
Regioni1167 – 1191DisorderedSequence analysisAdd BLAST25
Regioni1232 – 1315DisorderedSequence analysisAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi503 – 520PolarSequence analysisAdd BLAST18
Compositional biasi535 – 549BasicSequence analysisAdd BLAST15
Compositional biasi748 – 785PolarSequence analysisAdd BLAST38
Compositional biasi1173 – 1191PolarSequence analysisAdd BLAST19
Compositional biasi1249 – 1274PolarSequence analysisAdd BLAST26
Compositional biasi1293 – 1315PolarSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2503, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002083_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		CRNNMNP

Database of Orthologous Groups

More...OrthoDBi		1445357at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01167, Tub, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00969, SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF158235, SSF158235, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50225, SOCS, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VB18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLHFERNIN TKCDCTILSL SWMGKVPDDI PEDEGWKLNR TNYYQEGWLA 
        60         70         80         90        100
TGNVRGIVGV TFTTSHCRKN MDYPLRTNYN LRGHRSDVIL VKWNEPYQKL 
       110        120        130        140        150
ASCDSSGIIF VWIKYEGRWS IELINDRNTP VTHFSWSHDG RMALICYQDG 
       160        170        180        190        200
FVLVGSVAGQ RYWSSMLNLE STITCGIWTP DDQQVYFGTT QGQVIVMDVH 
       210        220        230        240        250
GAMVSQVQLS NDVPITSMAW SCEKFKMEEG EEAEPGVTNA AKRSFVLAVS 
       260        270        280        290        300
FQNGYIYLLK SFDDVSPAHI NTCLNGALGM VMEWSNSREL LAVAGTLRTG 
       310        320        330        340        350
VDGTKTEDMG TPSCYTNLVK FYTETGTCLY QAHIPCSSAT VSAITWGHND 
       360        370        380        390        400
KRLFIATGTQ VHIAWVSRRV ASLQLLCRLE IQASVGSESL LPLLPLPSRI 
       410        420        430        440        450
KSLIGNLFAQ TIRCCVPDLK SLRDFVSRPP LCSTRLHCTM IRHDDDSNLS 
       460        470        480        490        500
SGTCYTLYLE YLGGLVPLLK GKRTSKIRPE FVIFDPQVND SPLYFQYSAE 
       510        520        530        540        550
AKSSSGSSQS TTTGNSGRTD SSDSDFEERS RFGSPRTPRK KRVRPKRRHQ 
       560        570        580        590        600
AGDRLSASGG GVSNDPDSLD ELAYVDTLPE EVKLVEVTSN IWGTKFKIHG 
       610        620        630        640        650
LAKTVPANLG QVTYKTSLLH LQPRQMTLVI TELRDDFPPG PDPSFNPNIF 
       660        670        680        690        700
SEDEDEHHQH QGIHHDAVPQ VNVITAQDGA SLKPPIIPQR RLTDGASAPL 
       710        720        730        740        750
IAPMSPRPNR ILARHKNSLT VNGERGSGSS AGLSPLARAE SYDDDSSNES 
       760        770        780        790        800
QEAGAAGSQS TTVLLHQAPS NGSGPGPSCS KSITRPKTIS SFKNSYSRSS 
       810        820        830        840        850
SNSSCQSRHA ISPLYCDGAV PTLQSPKNAV APSDIIFERP AVPAAGQTTL 
       860        870        880        890        900
MSYSSNADYA NNVVQVKNAL MSEPVRSANS HVNPVPLNLN LNLERMDARV 
       910        920        930        940        950
KCTAPTTSST AKRREMLYID EETQSPTPTP SSSSMKRTPT VVSIAPALPD 
       960        970        980        990       1000
SITRSCSVGY LDSVAITPSD EALSALRKDA PNKRLILVDK KRNRRKRQQQ 
      1010       1020       1030       1040       1050
EDARRHKLQQ TGKSKSLDSC DLLSLQTKLS SKEHEQVVRK LQEISDSSAC 
      1060       1070       1080       1090       1100
SSAANTLCFK CRNNMSPSSA CKRCQPSASS VLDEITAVVP AVEPAKESPA 
      1110       1120       1130       1140       1150
VQAKPAPKKR FDVITSFTDS PLFTRKHRFG IGRSKETAGT ENSTPLLGRK 
      1160       1170       1180       1190       1200
QDNGFSFVKQ LSEVRWRRKE QPAQAQVNGS SNASTLERQP QPEITGAACG 
      1210       1220       1230       1240       1250
TVEATPVEAK ASVSLHTQAL TTLENIISRL RDLDEGRLTP PSTPQRLPRS 
      1260       1270       1280       1290       1300
SPASPAASKK NKRQQSNSPI RHILNSPLLN RRQRKKQSII ESSDDEGNQT 
      1310       1320       1330       1340       1350
NGSGEESNNA GNGKQYRDLE TFQKAQLRQK LKRGKIEPNG SASCANPAPV 
      1360       1370       1380       1390       1400
RREFVMHNKA PMWNEMSQVY QLDFGGRVTQ ESAKNFQIEF RGKQVMQFGR 
      1410       1420       1430 
IDGNAYTLDF QYPFSALQAF AVALANVTQR LK
Length:1,432
Mass (Da):157,730
Last modified:April 1, 2015 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i503D9508D04DDC9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KI44A0A0B4KI44_DROME
Tusp, isoform F
Tusp Dmel\CG5586, DMG2-MB6.chr3R.24.043, TUSP, CG5586, Dmel_CG5586
1,433Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHZ3A0A0B4KHZ3_DROME
Tusp, isoform G
Tusp Dmel\CG5586, DMG2-MB6.chr3R.24.043, TUSP, CG5586, Dmel_CG5586
1,430Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56725.4
AE014297 Genomic DNA Translation: ADV37393.1
BT132902 mRNA Translation: AEV66552.1

NCBI Reference Sequences

More...RefSeqi		NP_001189303.1, NM_001202374.2
NP_651573.4, NM_143316.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0302589; FBpp0291745; FBgn0039530
FBtr0302590; FBpp0291746; FBgn0039530

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG5586

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56725.4
AE014297 Genomic DNA Translation: ADV37393.1
BT132902 mRNA Translation: AEV66552.1
RefSeqiNP_001189303.1, NM_001202374.2
NP_651573.4, NM_143316.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VB18, 3 interactors
STRINGi7227.FBpp0291746

Genome annotation databases

EnsemblMetazoaiFBtr0302589; FBpp0291745; FBgn0039530
FBtr0302590; FBpp0291746; FBgn0039530
GeneIDi43317
KEGGidme:Dmel_CG5586

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43317
FlyBaseiFBgn0039530, Tusp

Phylogenomic databases

eggNOGiKOG2503, Eukaryota
GeneTreeiENSGT00940000155913
HOGENOMiCLU_002083_0_0_1
OMAiCRNNMNP
OrthoDBi1445357at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		43317, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43317

Gene expression databases

BgeeiFBgn0039530, Expressed in head and 23 other tissues

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496, SOCS_box
IPR036036, SOCS_box-like_dom_sf
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167, Tub, 1 hit
SMARTiView protein in SMART
SM00969, SOCS_box, 1 hit
SUPFAMiSSF158235, SSF158235, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50225, SOCS, 1 hit
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VB18_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VB18
Secondary accession number(s): H0RNI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: April 1, 2015
Last modified: February 10, 2021
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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