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Entry version 148 (07 Apr 2021)
Sequence version 5 (21 Sep 2011)
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Protein

La-related protein 1

Gene

larp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein required during male meiosis and development of the syncytial embryo (PubMed:17951964, PubMed:19631203, PubMed:30772175). Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation (PubMed:17951964, PubMed:19631203).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
dLarp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:larp
ORF Names:CG42551
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261618, larp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant males show multiple meiotic phenotypes such as a failure of chromosome segregation, cytokinesis and mitochondrial partition. Defects in spindle pole organization and spindle formation. Mutant-derived syncytial embryos show a range of mitotic phenotypes, including failure of centrosomes to migrate around the nuclear envelope, detachment of centrosomes from spindle poles, the formation of multipolar spindle arrays and cytokinetic defects.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66S → A: Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-107. In larp-10A, loss of phosphorylation by Pink1; when associated with A-107; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512. 1 Publication1
Mutagenesisi66S → D: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-107. 1 Publication1
Mutagenesisi107T → A: Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-66. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512. 1 Publication1
Mutagenesisi107T → D: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-66. 1 Publication1
Mutagenesisi182S → A: Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-186. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512. 1 Publication1
Mutagenesisi182S → D: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-186. 1 Publication1
Mutagenesisi186S → A: Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-182. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512. 1 Publication1
Mutagenesisi186S → D: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-182. 1 Publication1
Mutagenesisi219 – 221SPS → APA: Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; A-828; A-1119 and 1510-A-A-1512. 1 Publication3
Mutagenesisi828T → A: Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-1119 and 1510-A-A-1512. 1 Publication1
Mutagenesisi828T → D: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants. 1 Publication1
Mutagenesisi1119S → A: Partially rescues nascent protein synthesis and tam expression in mitochondria containing deleterious mutations. Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and 1510-A-A-1512. 1 Publication1
Mutagenesisi1119S → D: Phosphomimetic mutant, severe reduction in ability to rescue mtDNA levels and hatching rate in spoon null mutants. 1 Publication1
Mutagenesisi1510 – 1512SVS → AVA: Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and A-1119. 1 Publication3
Mutagenesisi1510 – 1512SVS → DVD: Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants. 1 Publication3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076131 – 1673La-related protein 1Add BLAST1673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66Phosphoserine2 Publications1
Modified residuei69Phosphoserine2 Publications1
Modified residuei102Phosphoserine1 Publication1
Modified residuei107Phosphothreonine2 Publications1
Modified residuei111Phosphoserine1 Publication1
Modified residuei112Phosphoserine1 Publication1
Modified residuei182Phosphoserine1 Publication1
Modified residuei186Phosphoserine1 Publication1
Modified residuei219Phosphoserine2 Publications1
Modified residuei221Phosphoserine2 Publications1
Modified residuei223Phosphoserine1 Publication1
Modified residuei229Phosphoserine1 Publication1
Modified residuei230Phosphoserine1 Publication1
Modified residuei236Phosphoserine1 Publication1
Modified residuei284Phosphoserine1 Publication1
Modified residuei562Phosphoserine1 Publication1
Modified residuei608Phosphoserine1 Publication1
Modified residuei828Phosphothreonine1 Publication1
Modified residuei851Phosphoserine1 Publication1
Modified residuei1119Phosphoserine2 Publications1
Modified residuei1124Phosphoserine1 Publication1
Modified residuei1261Phosphoserine1 Publication1
Modified residuei1315Phosphotyrosine1 Publication1
Modified residuei1510Phosphoserine2 Publications1
Modified residuei1512Phosphoserine2 Publications1
Modified residuei1578Phosphoserine1 Publication1
Modified residuei1585Phosphoserine1 Publication1
Modified residuei1610Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on threonine and serine residues (PubMed:30772175). During oogenesis, phosphorylation on Ser-1119 by Pink1 at the outer membrane of defective mitochondria, impairs its ability to promote local translation and mtDNA replication thus reducing transmission of deleterious mtDNA mutations to the mature oocyte (PubMed:30772175).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VAW5

PRoteomics IDEntifications database

More...
PRIDEi
Q9VAW5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VAW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At the end of embryogenesis, accumulates in the gut and muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261618, Expressed in pupa and 61 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VAW5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VAW5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with pAbp.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
72798, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VAW5, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9VAW5

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290398

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VAW5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini723 – 814HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi296 – 301Poly-Gln6
Compositional biasi322 – 329Poly-Gln8
Compositional biasi332 – 339Poly-Thr8
Compositional biasi340 – 354Poly-AlaAdd BLAST15
Compositional biasi372 – 380Poly-Thr9
Compositional biasi480 – 487Poly-Thr8
Compositional biasi869 – 874Poly-Pro6
Compositional biasi985 – 988Poly-Gln4
Compositional biasi996 – 1001Poly-Asn6
Compositional biasi1042 – 1055Poly-ThrAdd BLAST14
Compositional biasi1221 – 1225Poly-Pro5
Compositional biasi1543 – 1553Poly-GlnAdd BLAST11
Compositional biasi1620 – 1623Poly-Gln4
Compositional biasi1665 – 1671Poly-Ser7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2590, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169209

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VAW5

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMWKEVK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VAW5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05383, La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50961, HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: Q9VAW5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKEETPST GGAAPVATVA ASGSATTSYA NVVQNLETKK SGTSNTTTTT
60 70 80 90 100
ARATVDNKEN QPNLKSFKSW SEEAAAAEAA GESPIVGSVS LAQTGEKRAA
110 120 130 140 150
ASGGDNTAEN SSELDDNNDF VPVLSHHRRD RKKARKEKPR DQQPAGGRGD
160 170 180 190 200
GQKPQQAGGR RVPGSSDTER KSVRPRAPRG GSPRKSAAGA AGAAGSNAGA
210 220 230 240 250
VSSAVPGGPK VHKDRKDTSP SASIEGAGSS GNEAKSADGD QQAGEKGAAG
260 270 280 290 300
AAPPPKRFIA APPPKVNAWK ISAKQSGSPK AGTSPLDKRV LQPKAQQQQQ
310 320 330 340 350
QTKQTASQNN NAQNTASNKK TQQQQQPQQG ATTTTQTTTA AAAAATAAAA
360 370 380 390 400
ATAATTSAAA ATSSAAAVPA ATTETATTTT VDASQADALA KVVVKDKKKV
410 420 430 440 450
NQKASDFSNV GDWPTLIGGT SGSGKATSNE PKRNPTKKQQ SAKTAAAVAA
460 470 480 490 500
SSNTTSSEVA TESNVAGTTS SSNSNPSSST TTTNTTTNSQ ATTAPVASTS
510 520 530 540 550
HDAKAQRDAE PAANSAAGTT GTAAGPALTK KIPKHKWRPL PIDLAKSSRP
560 570 580 590 600
KPIGGRPNRR FSDDIADQRR PPRVYHDRQP GAGGAGVESR HPHAGRHPYG
610 620 630 640 650
SRPATATSER VDSWRSSSST TTAAFDEQRS GAAGGAGAAG TGVGSATRGP
660 670 680 690 700
RRYRTPYRGG RQGRGGFSRQ GPGRPTYRIP RHLLASGEYA NYLPADAAGA
710 720 730 740 750
DSQSSYVLMG THYFGNVPAA YIELDANSIK EAIKKQVEYY FSVDNLTGDF
760 770 780 790 800
FLRRKMDPEG YIPVTLIASF HRVLALTTDV AVIVNAIKES DKLELFEGYK
810 820 830 840 850
VRTKTTPTTW PITEVPEVNE GEPKAIGTLE QEQLEQNDGQ EKLEEQTEAD
860 870 880 890 900
SPPPILTSAM ATKPLNSIPP PPMPRNPQNL VPKMLQDKQQ SRSSTIAALN
910 920 930 940 950
SVNAISALTQ QVEGGAAELA GHLSGLAESV KPKSTSTPDK RNAASAGNGA
960 970 980 990 1000
GSAAALVAEP EGIWKEVKRR SKTNAIKENA TTPPQQQQPP LSQTLNNNND
1010 1020 1030 1040 1050
NVKTNNTSSK SKSSSNNAPS NASSSATVCV TTNNASSATK ATTKTTTTST
1060 1070 1080 1090 1100
ATTTTNNNIK SGNAAYSKTH SKSSSKTAAP PSAQCHAEKE ELDFQFDEEL
1110 1120 1130 1140 1150
MDPLPPGTGR INNFTENFSD DDESDYEFAD RDINKLLIVA QVGRAPKHEG
1160 1170 1180 1190 1200
YDRTADFTSR TKITQDLENI INDGLVNYEE DLWTTTNVVA DYKTVNVISQ
1210 1220 1230 1240 1250
ADFEKLAGGR NKSVLPPQVV PPPPPFEEDL DETLVGDTTL NSTLNNTLKS
1260 1270 1280 1290 1300
RRARFYAAPN SHSIDPRTPR KRKLRHTANP PVEAHVGWLL DTVEHRPRTT
1310 1320 1330 1340 1350
SMGSSAGTSP TASSYGSFGS SVPQSLPVFQ HPSHALLKEN NFTQQAYHKY
1360 1370 1380 1390 1400
HSRCLKERRR LGYGQSQEMN TLYRFWSFFL RENFNKSMYN EFRSLALEDA
1410 1420 1430 1440 1450
GNGFRYGLEC LFRFFSYGLE KKFRPNIYQD FQDETIADYE TGQLYGLEKF
1460 1470 1480 1490 1500
WAFLKYYKNG EKLEVQPKLA EYLKSFKNIE DFRVVEPEIN EMLQGVGSLN
1510 1520 1530 1540 1550
PGRQLNRHRS VSESDGTAVI AAGGRRLNTT ITNRSDYVGR LLQQQHQQQQ
1560 1570 1580 1590 1600
QQQHHQYQQG YGGYNQQQNR RRTGSFGSTT VRIRSGSLGN KPQVANRNQG
1610 1620 1630 1640 1650
SQHELRRGGS NSGLAPHKRQ QQQKPKPGAG SQTGSTRATT SAAATATTAA
1660 1670
SAATSTAATP AVTVSSGSSS SKK
Length:1,673
Mass (Da):178,145
Last modified:September 21, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD865CDA3103B1429
GO
Isoform C (identifier: Q9VAW5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.
     271-271: I → M

Show »
Length:1,403
Mass (Da):150,937
Checksum:iB90DC1BB792454EF
GO
Isoform A (identifier: Q9VAW5-2) [UniParc]FASTAAdd to basket
Also known as: B, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-708: Missing.

Show »
Length:965
Mass (Da):106,221
Checksum:i83B79ACAF6B9FB66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K7Y7A0A0B4K7Y7_DROME
La related protein, isoform G
larp 0031, 0225, 08, 29, BcDNA:LD02611
1,673Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6K9A0A0B4K6K9_DROME
La related protein, isoform F
larp 0031, 0225, 08, 29, BcDNA:LD02611
1,409Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF35862 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM29658 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM49837 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21A → V in ACY39986 (Ref. 5) Curated1
Sequence conflicti42G → D in ACY39986 (Ref. 5) Curated1
Sequence conflicti205V → A in ACY39986 (Ref. 5) Curated1
Sequence conflicti248A → T in ACY39986 (Ref. 5) Curated1
Sequence conflicti348A → V in ACY39986 (Ref. 5) Curated1
Sequence conflicti351 – 352AT → TA in ACY39986 (Ref. 5) Curated2
Sequence conflicti355 – 356TT → KA in ACY39986 (Ref. 5) Curated2
Sequence conflicti369P → A in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti476P → S in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti489S → R in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti512A → E in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti641T → A in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti668S → T in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti677Y → H in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti819N → T in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti819N → T in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti1100L → V in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti1648T → A in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti1648T → A in AAM49837 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151171 – 708Missing in isoform A. CuratedAdd BLAST708
Alternative sequenceiVSP_0417751 – 270Missing in isoform C. 2 PublicationsAdd BLAST270
Alternative sequenceiVSP_041776271I → M in isoform C. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF221108 mRNA Translation: AAF35862.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56783.3
AE014297 Genomic DNA Translation: AAN14138.5
AE014297 Genomic DNA Translation: AAN14139.1
AE014297 Genomic DNA Translation: ACZ95051.1
AY113653 mRNA Translation: AAM29658.1 Sequence problems.
AY118468 mRNA Translation: AAM49837.1 Different initiation.
BT100187 mRNA Translation: ACY39986.1

NCBI Reference Sequences

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RefSeqi
NP_001163757.1, NM_001170286.3 [Q9VAW5-2]
NP_001247347.1, NM_001260418.2 [Q9VAW5-3]
NP_001247348.1, NM_001260419.2 [Q9VAW5-3]
NP_524998.1, NM_080259.3 [Q9VAW5-2]
NP_733244.5, NM_170365.4 [Q9VAW5-3]
NP_733245.1, NM_170366.4 [Q9VAW5-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2]
FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2]
FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3]
FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2]
FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3]
FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53567

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG42551

UCSC genome browser

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UCSCi
CG14066-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221108 mRNA Translation: AAF35862.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56783.3
AE014297 Genomic DNA Translation: AAN14138.5
AE014297 Genomic DNA Translation: AAN14139.1
AE014297 Genomic DNA Translation: ACZ95051.1
AY113653 mRNA Translation: AAM29658.1 Sequence problems.
AY118468 mRNA Translation: AAM49837.1 Different initiation.
BT100187 mRNA Translation: ACY39986.1
RefSeqiNP_001163757.1, NM_001170286.3 [Q9VAW5-2]
NP_001247347.1, NM_001260418.2 [Q9VAW5-3]
NP_001247348.1, NM_001260419.2 [Q9VAW5-3]
NP_524998.1, NM_080259.3 [Q9VAW5-2]
NP_733244.5, NM_170365.4 [Q9VAW5-3]
NP_733245.1, NM_170366.4 [Q9VAW5-2]

3D structure databases

SMRiQ9VAW5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi72798, 22 interactors
IntActiQ9VAW5, 20 interactors
MINTiQ9VAW5
STRINGi7227.FBpp0290398

PTM databases

iPTMnetiQ9VAW5

Proteomic databases

PaxDbiQ9VAW5
PRIDEiQ9VAW5

Genome annotation databases

EnsemblMetazoaiFBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2]
FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2]
FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3]
FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2]
FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3]
FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3]
GeneIDi53567
KEGGidme:Dmel_CG42551
UCSCiCG14066-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
53567
FlyBaseiFBgn0261618, larp

Phylogenomic databases

eggNOGiKOG2590, Eukaryota
GeneTreeiENSGT00940000169209
InParanoidiQ9VAW5
OMAiGMWKEVK
PhylomeDBiQ9VAW5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
53567, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
larp, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53567

Protein Ontology

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PROi
PR:Q9VAW5

Gene expression databases

BgeeiFBgn0261618, Expressed in pupa and 61 other tissues
ExpressionAtlasiQ9VAW5, baseline and differential
GenevisibleiQ9VAW5, DM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
SMARTiView protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VAW5
Secondary accession number(s): A4V3J4
, D0IQE9, E1JJ02, Q8IMM4, Q8MSZ4, Q8MYR3, Q9NHN6, Q9VAW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: September 21, 2011
Last modified: April 7, 2021
This is version 148 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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