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UniProtKB - Q9VAW5 (LARP_DROME)

Entry version 147 (10 Feb 2021)
Sequence version 5 (21 Sep 2011)
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Protein

La-related protein 1

Gene

larp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
dLarp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:larp
ORF Names:CG42551
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0261618, larp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant males show multiple meiotic phenotypes such as a failure of chromosome segregation, cytokinesis and mitochondrial partition. Defects in spindle pole organization and spindle formation. Mutant-derived syncytial embryos show a range of mitotic phenotypes, including failure of centrosomes to migrate around the nuclear envelope, detachment of centrosomes from spindle poles, the formation of multipolar spindle arrays and cytokinetic defects.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076131 – 1673La-related protein 1Add BLAST1673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66Phosphoserine1 Publication1
Modified residuei69Phosphoserine2 Publications1
Modified residuei102Phosphoserine1 Publication1
Modified residuei107Phosphothreonine1 Publication1
Modified residuei111Phosphoserine1 Publication1
Modified residuei112Phosphoserine1 Publication1
Modified residuei219Phosphoserine1 Publication1
Modified residuei221Phosphoserine1 Publication1
Modified residuei223Phosphoserine1 Publication1
Modified residuei229Phosphoserine1 Publication1
Modified residuei230Phosphoserine1 Publication1
Modified residuei236Phosphoserine1 Publication1
Modified residuei284Phosphoserine1 Publication1
Modified residuei562Phosphoserine1 Publication1
Modified residuei608Phosphoserine1 Publication1
Modified residuei851Phosphoserine1 Publication1
Modified residuei1119Phosphoserine1 Publication1
Modified residuei1124Phosphoserine1 Publication1
Modified residuei1261Phosphoserine1 Publication1
Modified residuei1315Phosphotyrosine1 Publication1
Modified residuei1510Phosphoserine1 Publication1
Modified residuei1512Phosphoserine1 Publication1
Modified residuei1578Phosphoserine1 Publication1
Modified residuei1585Phosphoserine1 Publication1
Modified residuei1610Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VAW5

PRoteomics IDEntifications database

More...PRIDEi		Q9VAW5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9VAW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At the end of embryogenesis, accumulates in the gut and muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0261618, Expressed in pupa and 61 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VAW5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VAW5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with pAbp.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		72798, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9VAW5, 20 interactors

Molecular INTeraction database

More...MINTi		Q9VAW5

STRING: functional protein association networks

More...STRINGi		7227.FBpp0290398

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VAW5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini723 – 814HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi296 – 301Poly-Gln6
Compositional biasi322 – 329Poly-Gln8
Compositional biasi332 – 339Poly-Thr8
Compositional biasi340 – 354Poly-AlaAdd BLAST15
Compositional biasi372 – 380Poly-Thr9
Compositional biasi480 – 487Poly-Thr8
Compositional biasi869 – 874Poly-Pro6
Compositional biasi985 – 988Poly-Gln4
Compositional biasi996 – 1001Poly-Asn6
Compositional biasi1042 – 1055Poly-ThrAdd BLAST14
Compositional biasi1221 – 1225Poly-Pro5
Compositional biasi1543 – 1553Poly-GlnAdd BLAST11
Compositional biasi1620 – 1623Poly-Gln4
Compositional biasi1665 – 1671Poly-Ser7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2590, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169209

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VAW5

Identification of Orthologs from Complete Genome Data

More...OMAi		GMWKEVK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VAW5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05383, La, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50961, HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform D (identifier: Q9VAW5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKEETPST GGAAPVATVA ASGSATTSYA NVVQNLETKK SGTSNTTTTT 
        60         70         80         90        100
ARATVDNKEN QPNLKSFKSW SEEAAAAEAA GESPIVGSVS LAQTGEKRAA 
       110        120        130        140        150
ASGGDNTAEN SSELDDNNDF VPVLSHHRRD RKKARKEKPR DQQPAGGRGD 
       160        170        180        190        200
GQKPQQAGGR RVPGSSDTER KSVRPRAPRG GSPRKSAAGA AGAAGSNAGA 
       210        220        230        240        250
VSSAVPGGPK VHKDRKDTSP SASIEGAGSS GNEAKSADGD QQAGEKGAAG 
       260        270        280        290        300
AAPPPKRFIA APPPKVNAWK ISAKQSGSPK AGTSPLDKRV LQPKAQQQQQ 
       310        320        330        340        350
QTKQTASQNN NAQNTASNKK TQQQQQPQQG ATTTTQTTTA AAAAATAAAA 
       360        370        380        390        400
ATAATTSAAA ATSSAAAVPA ATTETATTTT VDASQADALA KVVVKDKKKV 
       410        420        430        440        450
NQKASDFSNV GDWPTLIGGT SGSGKATSNE PKRNPTKKQQ SAKTAAAVAA 
       460        470        480        490        500
SSNTTSSEVA TESNVAGTTS SSNSNPSSST TTTNTTTNSQ ATTAPVASTS 
       510        520        530        540        550
HDAKAQRDAE PAANSAAGTT GTAAGPALTK KIPKHKWRPL PIDLAKSSRP 
       560        570        580        590        600
KPIGGRPNRR FSDDIADQRR PPRVYHDRQP GAGGAGVESR HPHAGRHPYG 
       610        620        630        640        650
SRPATATSER VDSWRSSSST TTAAFDEQRS GAAGGAGAAG TGVGSATRGP 
       660        670        680        690        700
RRYRTPYRGG RQGRGGFSRQ GPGRPTYRIP RHLLASGEYA NYLPADAAGA 
       710        720        730        740        750
DSQSSYVLMG THYFGNVPAA YIELDANSIK EAIKKQVEYY FSVDNLTGDF 
       760        770        780        790        800
FLRRKMDPEG YIPVTLIASF HRVLALTTDV AVIVNAIKES DKLELFEGYK 
       810        820        830        840        850
VRTKTTPTTW PITEVPEVNE GEPKAIGTLE QEQLEQNDGQ EKLEEQTEAD 
       860        870        880        890        900
SPPPILTSAM ATKPLNSIPP PPMPRNPQNL VPKMLQDKQQ SRSSTIAALN 
       910        920        930        940        950
SVNAISALTQ QVEGGAAELA GHLSGLAESV KPKSTSTPDK RNAASAGNGA 
       960        970        980        990       1000
GSAAALVAEP EGIWKEVKRR SKTNAIKENA TTPPQQQQPP LSQTLNNNND 
      1010       1020       1030       1040       1050
NVKTNNTSSK SKSSSNNAPS NASSSATVCV TTNNASSATK ATTKTTTTST 
      1060       1070       1080       1090       1100
ATTTTNNNIK SGNAAYSKTH SKSSSKTAAP PSAQCHAEKE ELDFQFDEEL 
      1110       1120       1130       1140       1150
MDPLPPGTGR INNFTENFSD DDESDYEFAD RDINKLLIVA QVGRAPKHEG 
      1160       1170       1180       1190       1200
YDRTADFTSR TKITQDLENI INDGLVNYEE DLWTTTNVVA DYKTVNVISQ 
      1210       1220       1230       1240       1250
ADFEKLAGGR NKSVLPPQVV PPPPPFEEDL DETLVGDTTL NSTLNNTLKS 
      1260       1270       1280       1290       1300
RRARFYAAPN SHSIDPRTPR KRKLRHTANP PVEAHVGWLL DTVEHRPRTT 
      1310       1320       1330       1340       1350
SMGSSAGTSP TASSYGSFGS SVPQSLPVFQ HPSHALLKEN NFTQQAYHKY 
      1360       1370       1380       1390       1400
HSRCLKERRR LGYGQSQEMN TLYRFWSFFL RENFNKSMYN EFRSLALEDA 
      1410       1420       1430       1440       1450
GNGFRYGLEC LFRFFSYGLE KKFRPNIYQD FQDETIADYE TGQLYGLEKF 
      1460       1470       1480       1490       1500
WAFLKYYKNG EKLEVQPKLA EYLKSFKNIE DFRVVEPEIN EMLQGVGSLN 
      1510       1520       1530       1540       1550
PGRQLNRHRS VSESDGTAVI AAGGRRLNTT ITNRSDYVGR LLQQQHQQQQ 
      1560       1570       1580       1590       1600
QQQHHQYQQG YGGYNQQQNR RRTGSFGSTT VRIRSGSLGN KPQVANRNQG 
      1610       1620       1630       1640       1650
SQHELRRGGS NSGLAPHKRQ QQQKPKPGAG SQTGSTRATT SAAATATTAA 
      1660       1670 
SAATSTAATP AVTVSSGSSS SKK
Length:1,673
Mass (Da):178,145
Last modified:September 21, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD865CDA3103B1429
GO
Isoform C (identifier: Q9VAW5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.
     271-271: I → M

Show »
Length:1,403
Mass (Da):150,937
Checksum:iB90DC1BB792454EF
GO
Isoform A (identifier: Q9VAW5-2) [UniParc]FASTAAdd to basket
Also known as: B, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-708: Missing.

Show »
Length:965
Mass (Da):106,221
Checksum:i83B79ACAF6B9FB66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6K9A0A0B4K6K9_DROME
La related protein, isoform F
larp 0031, 0225, 08, 29, BcDNA:LD02611
1,409Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7Y7A0A0B4K7Y7_DROME
La related protein, isoform G
larp 0031, 0225, 08, 29, BcDNA:LD02611
1,673Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF35862 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM29658 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM49837 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21A → V in ACY39986 (Ref. 5) Curated1
Sequence conflicti42G → D in ACY39986 (Ref. 5) Curated1
Sequence conflicti205V → A in ACY39986 (Ref. 5) Curated1
Sequence conflicti248A → T in ACY39986 (Ref. 5) Curated1
Sequence conflicti348A → V in ACY39986 (Ref. 5) Curated1
Sequence conflicti351 – 352AT → TA in ACY39986 (Ref. 5) Curated2
Sequence conflicti355 – 356TT → KA in ACY39986 (Ref. 5) Curated2
Sequence conflicti369P → A in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti476P → S in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti489S → R in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti512A → E in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti641T → A in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti668S → T in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti677Y → H in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti819N → T in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti819N → T in AAM29658 (PubMed:12537569).Curated1
Sequence conflicti1100L → V in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti1648T → A in AAF35862 (PubMed:10878606).Curated1
Sequence conflicti1648T → A in AAM49837 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0151171 – 708Missing in isoform A. CuratedAdd BLAST708
Alternative sequenceiVSP_0417751 – 270Missing in isoform C. 2 PublicationsAdd BLAST270
Alternative sequenceiVSP_041776271I → M in isoform C. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF221108 mRNA Translation: AAF35862.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56783.3
AE014297 Genomic DNA Translation: AAN14138.5
AE014297 Genomic DNA Translation: AAN14139.1
AE014297 Genomic DNA Translation: ACZ95051.1
AY113653 mRNA Translation: AAM29658.1 Sequence problems.
AY118468 mRNA Translation: AAM49837.1 Different initiation.
BT100187 mRNA Translation: ACY39986.1

NCBI Reference Sequences

More...RefSeqi		NP_001163757.1, NM_001170286.3 [Q9VAW5-2]
NP_001247347.1, NM_001260418.2 [Q9VAW5-3]
NP_001247348.1, NM_001260419.2 [Q9VAW5-3]
NP_524998.1, NM_080259.3 [Q9VAW5-2]
NP_733244.5, NM_170365.4 [Q9VAW5-3]
NP_733245.1, NM_170366.4 [Q9VAW5-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2]
FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2]
FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3]
FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2]
FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3]
FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG42551

UCSC genome browser

More...UCSCi		CG14066-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221108 mRNA Translation: AAF35862.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56783.3
AE014297 Genomic DNA Translation: AAN14138.5
AE014297 Genomic DNA Translation: AAN14139.1
AE014297 Genomic DNA Translation: ACZ95051.1
AY113653 mRNA Translation: AAM29658.1 Sequence problems.
AY118468 mRNA Translation: AAM49837.1 Different initiation.
BT100187 mRNA Translation: ACY39986.1
RefSeqiNP_001163757.1, NM_001170286.3 [Q9VAW5-2]
NP_001247347.1, NM_001260418.2 [Q9VAW5-3]
NP_001247348.1, NM_001260419.2 [Q9VAW5-3]
NP_524998.1, NM_080259.3 [Q9VAW5-2]
NP_733244.5, NM_170365.4 [Q9VAW5-3]
NP_733245.1, NM_170366.4 [Q9VAW5-2]

3D structure databases

SMRiQ9VAW5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi72798, 21 interactors
IntActiQ9VAW5, 20 interactors
MINTiQ9VAW5
STRINGi7227.FBpp0290398

PTM databases

iPTMnetiQ9VAW5

Proteomic databases

PaxDbiQ9VAW5
PRIDEiQ9VAW5

Genome annotation databases

EnsemblMetazoaiFBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2]
FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2]
FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3]
FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2]
FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3]
FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3]
GeneIDi53567
KEGGidme:Dmel_CG42551
UCSCiCG14066-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53567
FlyBaseiFBgn0261618, larp

Phylogenomic databases

eggNOGiKOG2590, Eukaryota
GeneTreeiENSGT00940000169209
InParanoidiQ9VAW5
OMAiGMWKEVK
PhylomeDBiQ9VAW5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53567, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		larp, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53567

Protein Ontology

More...PROi		PR:Q9VAW5

Gene expression databases

BgeeiFBgn0261618, Expressed in pupa and 61 other tissues
ExpressionAtlasiQ9VAW5, baseline and differential
GenevisibleiQ9VAW5, DM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR006607, DM15
IPR006630, La_HTH
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
SMARTiView protein in SMART
SM00684, DM15, 3 hits
SM00715, LA, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLARP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VAW5
Secondary accession number(s): A4V3J4
, D0IQE9, E1JJ02, Q8IMM4, Q8MSZ4, Q8MYR3, Q9NHN6, Q9VAW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: September 21, 2011
Last modified: February 10, 2021
This is version 147 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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