UniProtKB - Q9VAW5 (LARP_DROME)
Protein
La-related protein 1
Gene
larp
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation.2 Publications
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- male meiotic nuclear division Source: FlyBase
- mitochondrion inheritance Source: FlyBase
- positive regulation of mitochondrial DNA replication Source: FlyBase
- positive regulation of mitochondrial translation Source: FlyBase
- spindle assembly involved in male meiosis Source: FlyBase
- syncytial blastoderm mitotic cell cycle Source: FlyBase
Keywordsi
Molecular function | RNA-binding |
Biological process | Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 1Alternative name(s): dLarp |
Gene namesi | Name:larp ORF Names:CG42551 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0261618, larp |
Subcellular locationi
Cytosol
- cytosol 3 Publications
Cytosol
- cytosol Source: FlyBase
Mitochondrion
- mitochondrion Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Mutant males show multiple meiotic phenotypes such as a failure of chromosome segregation, cytokinesis and mitochondrial partition. Defects in spindle pole organization and spindle formation. Mutant-derived syncytial embryos show a range of mitotic phenotypes, including failure of centrosomes to migrate around the nuclear envelope, detachment of centrosomes from spindle poles, the formation of multipolar spindle arrays and cytokinetic defects.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207613 | 1 – 1673 | La-related protein 1Add BLAST | 1673 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | Phosphoserine1 Publication | 1 | |
Modified residuei | 69 | Phosphoserine2 Publications | 1 | |
Modified residuei | 102 | Phosphoserine1 Publication | 1 | |
Modified residuei | 107 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 111 | Phosphoserine1 Publication | 1 | |
Modified residuei | 112 | Phosphoserine1 Publication | 1 | |
Modified residuei | 219 | Phosphoserine1 Publication | 1 | |
Modified residuei | 221 | Phosphoserine1 Publication | 1 | |
Modified residuei | 223 | Phosphoserine1 Publication | 1 | |
Modified residuei | 229 | Phosphoserine1 Publication | 1 | |
Modified residuei | 230 | Phosphoserine1 Publication | 1 | |
Modified residuei | 236 | Phosphoserine1 Publication | 1 | |
Modified residuei | 284 | Phosphoserine1 Publication | 1 | |
Modified residuei | 562 | Phosphoserine1 Publication | 1 | |
Modified residuei | 608 | Phosphoserine1 Publication | 1 | |
Modified residuei | 851 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1119 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1124 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1261 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1315 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 1510 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1512 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1578 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1585 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1610 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9VAW5 |
PRIDEi | Q9VAW5 |
PTM databases
iPTMneti | Q9VAW5 |
Expressioni
Developmental stagei
At the end of embryogenesis, accumulates in the gut and muscles.1 Publication
Gene expression databases
Bgeei | FBgn0261618, Expressed in pupa and 61 other tissues |
ExpressionAtlasi | Q9VAW5, baseline and differential |
Genevisiblei | Q9VAW5, DM |
Interactioni
Subunit structurei
Interacts with pAbp.
1 PublicationProtein-protein interaction databases
BioGRIDi | 72798, 21 interactors |
IntActi | Q9VAW5, 20 interactors |
MINTi | Q9VAW5 |
STRINGi | 7227.FBpp0290398 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 723 – 814 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 296 – 301 | Poly-Gln | 6 | |
Compositional biasi | 322 – 329 | Poly-Gln | 8 | |
Compositional biasi | 332 – 339 | Poly-Thr | 8 | |
Compositional biasi | 340 – 354 | Poly-AlaAdd BLAST | 15 | |
Compositional biasi | 372 – 380 | Poly-Thr | 9 | |
Compositional biasi | 480 – 487 | Poly-Thr | 8 | |
Compositional biasi | 869 – 874 | Poly-Pro | 6 | |
Compositional biasi | 985 – 988 | Poly-Gln | 4 | |
Compositional biasi | 996 – 1001 | Poly-Asn | 6 | |
Compositional biasi | 1042 – 1055 | Poly-ThrAdd BLAST | 14 | |
Compositional biasi | 1221 – 1225 | Poly-Pro | 5 | |
Compositional biasi | 1543 – 1553 | Poly-GlnAdd BLAST | 11 | |
Compositional biasi | 1620 – 1623 | Poly-Gln | 4 | |
Compositional biasi | 1665 – 1671 | Poly-Ser | 7 |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000169209 |
InParanoidi | Q9VAW5 |
OMAi | GMWKEVK |
PhylomeDBi | Q9VAW5 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform D (identifier: Q9VAW5-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSKEETPST GGAAPVATVA ASGSATTSYA NVVQNLETKK SGTSNTTTTT
60 70 80 90 100
ARATVDNKEN QPNLKSFKSW SEEAAAAEAA GESPIVGSVS LAQTGEKRAA
110 120 130 140 150
ASGGDNTAEN SSELDDNNDF VPVLSHHRRD RKKARKEKPR DQQPAGGRGD
160 170 180 190 200
GQKPQQAGGR RVPGSSDTER KSVRPRAPRG GSPRKSAAGA AGAAGSNAGA
210 220 230 240 250
VSSAVPGGPK VHKDRKDTSP SASIEGAGSS GNEAKSADGD QQAGEKGAAG
260 270 280 290 300
AAPPPKRFIA APPPKVNAWK ISAKQSGSPK AGTSPLDKRV LQPKAQQQQQ
310 320 330 340 350
QTKQTASQNN NAQNTASNKK TQQQQQPQQG ATTTTQTTTA AAAAATAAAA
360 370 380 390 400
ATAATTSAAA ATSSAAAVPA ATTETATTTT VDASQADALA KVVVKDKKKV
410 420 430 440 450
NQKASDFSNV GDWPTLIGGT SGSGKATSNE PKRNPTKKQQ SAKTAAAVAA
460 470 480 490 500
SSNTTSSEVA TESNVAGTTS SSNSNPSSST TTTNTTTNSQ ATTAPVASTS
510 520 530 540 550
HDAKAQRDAE PAANSAAGTT GTAAGPALTK KIPKHKWRPL PIDLAKSSRP
560 570 580 590 600
KPIGGRPNRR FSDDIADQRR PPRVYHDRQP GAGGAGVESR HPHAGRHPYG
610 620 630 640 650
SRPATATSER VDSWRSSSST TTAAFDEQRS GAAGGAGAAG TGVGSATRGP
660 670 680 690 700
RRYRTPYRGG RQGRGGFSRQ GPGRPTYRIP RHLLASGEYA NYLPADAAGA
710 720 730 740 750
DSQSSYVLMG THYFGNVPAA YIELDANSIK EAIKKQVEYY FSVDNLTGDF
760 770 780 790 800
FLRRKMDPEG YIPVTLIASF HRVLALTTDV AVIVNAIKES DKLELFEGYK
810 820 830 840 850
VRTKTTPTTW PITEVPEVNE GEPKAIGTLE QEQLEQNDGQ EKLEEQTEAD
860 870 880 890 900
SPPPILTSAM ATKPLNSIPP PPMPRNPQNL VPKMLQDKQQ SRSSTIAALN
910 920 930 940 950
SVNAISALTQ QVEGGAAELA GHLSGLAESV KPKSTSTPDK RNAASAGNGA
960 970 980 990 1000
GSAAALVAEP EGIWKEVKRR SKTNAIKENA TTPPQQQQPP LSQTLNNNND
1010 1020 1030 1040 1050
NVKTNNTSSK SKSSSNNAPS NASSSATVCV TTNNASSATK ATTKTTTTST
1060 1070 1080 1090 1100
ATTTTNNNIK SGNAAYSKTH SKSSSKTAAP PSAQCHAEKE ELDFQFDEEL
1110 1120 1130 1140 1150
MDPLPPGTGR INNFTENFSD DDESDYEFAD RDINKLLIVA QVGRAPKHEG
1160 1170 1180 1190 1200
YDRTADFTSR TKITQDLENI INDGLVNYEE DLWTTTNVVA DYKTVNVISQ
1210 1220 1230 1240 1250
ADFEKLAGGR NKSVLPPQVV PPPPPFEEDL DETLVGDTTL NSTLNNTLKS
1260 1270 1280 1290 1300
RRARFYAAPN SHSIDPRTPR KRKLRHTANP PVEAHVGWLL DTVEHRPRTT
1310 1320 1330 1340 1350
SMGSSAGTSP TASSYGSFGS SVPQSLPVFQ HPSHALLKEN NFTQQAYHKY
1360 1370 1380 1390 1400
HSRCLKERRR LGYGQSQEMN TLYRFWSFFL RENFNKSMYN EFRSLALEDA
1410 1420 1430 1440 1450
GNGFRYGLEC LFRFFSYGLE KKFRPNIYQD FQDETIADYE TGQLYGLEKF
1460 1470 1480 1490 1500
WAFLKYYKNG EKLEVQPKLA EYLKSFKNIE DFRVVEPEIN EMLQGVGSLN
1510 1520 1530 1540 1550
PGRQLNRHRS VSESDGTAVI AAGGRRLNTT ITNRSDYVGR LLQQQHQQQQ
1560 1570 1580 1590 1600
QQQHHQYQQG YGGYNQQQNR RRTGSFGSTT VRIRSGSLGN KPQVANRNQG
1610 1620 1630 1640 1650
SQHELRRGGS NSGLAPHKRQ QQQKPKPGAG SQTGSTRATT SAAATATTAA
1660 1670
SAATSTAATP AVTVSSGSSS SKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4K6K9 | A0A0B4K6K9_DROME | La related protein, isoform F | larp 0031, 0225, 08, 29, BcDNA:LD02611 | 1,409 | Annotation score: | ||
A0A0B4K7Y7 | A0A0B4K7Y7_DROME | La related protein, isoform G | larp 0031, 0225, 08, 29, BcDNA:LD02611 | 1,673 | Annotation score: |
Sequence cautioni
The sequence AAF35862 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAM29658 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM29658 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM49837 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | A → V in ACY39986 (Ref. 5) Curated | 1 | |
Sequence conflicti | 42 | G → D in ACY39986 (Ref. 5) Curated | 1 | |
Sequence conflicti | 205 | V → A in ACY39986 (Ref. 5) Curated | 1 | |
Sequence conflicti | 248 | A → T in ACY39986 (Ref. 5) Curated | 1 | |
Sequence conflicti | 348 | A → V in ACY39986 (Ref. 5) Curated | 1 | |
Sequence conflicti | 351 – 352 | AT → TA in ACY39986 (Ref. 5) Curated | 2 | |
Sequence conflicti | 355 – 356 | TT → KA in ACY39986 (Ref. 5) Curated | 2 | |
Sequence conflicti | 369 | P → A in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 476 | P → S in AAF35862 (PubMed:10878606).Curated | 1 | |
Sequence conflicti | 489 | S → R in AAF35862 (PubMed:10878606).Curated | 1 | |
Sequence conflicti | 512 | A → E in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 641 | T → A in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 668 | S → T in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 677 | Y → H in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 819 | N → T in AAF35862 (PubMed:10878606).Curated | 1 | |
Sequence conflicti | 819 | N → T in AAM29658 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 1100 | L → V in AAF35862 (PubMed:10878606).Curated | 1 | |
Sequence conflicti | 1648 | T → A in AAF35862 (PubMed:10878606).Curated | 1 | |
Sequence conflicti | 1648 | T → A in AAM49837 (PubMed:12537569).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015117 | 1 – 708 | Missing in isoform A. CuratedAdd BLAST | 708 | |
Alternative sequenceiVSP_041775 | 1 – 270 | Missing in isoform C. 2 PublicationsAdd BLAST | 270 | |
Alternative sequenceiVSP_041776 | 271 | I → M in isoform C. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221108 mRNA Translation: AAF35862.1 Sequence problems. AE014297 Genomic DNA Translation: AAF56783.3 AE014297 Genomic DNA Translation: AAN14138.5 AE014297 Genomic DNA Translation: AAN14139.1 AE014297 Genomic DNA Translation: ACZ95051.1 AY113653 mRNA Translation: AAM29658.1 Sequence problems. AY118468 mRNA Translation: AAM49837.1 Different initiation. BT100187 mRNA Translation: ACY39986.1 |
RefSeqi | NP_001163757.1, NM_001170286.3 [Q9VAW5-2] NP_001247347.1, NM_001260418.2 [Q9VAW5-3] NP_001247348.1, NM_001260419.2 [Q9VAW5-3] NP_524998.1, NM_080259.3 [Q9VAW5-2] NP_733244.5, NM_170365.4 [Q9VAW5-3] NP_733245.1, NM_170366.4 [Q9VAW5-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2] FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2] FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3] FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2] FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3] FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3] |
GeneIDi | 53567 |
KEGGi | dme:Dmel_CG42551 |
UCSCi | CG14066-RB, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221108 mRNA Translation: AAF35862.1 Sequence problems. AE014297 Genomic DNA Translation: AAF56783.3 AE014297 Genomic DNA Translation: AAN14138.5 AE014297 Genomic DNA Translation: AAN14139.1 AE014297 Genomic DNA Translation: ACZ95051.1 AY113653 mRNA Translation: AAM29658.1 Sequence problems. AY118468 mRNA Translation: AAM49837.1 Different initiation. BT100187 mRNA Translation: ACY39986.1 |
RefSeqi | NP_001163757.1, NM_001170286.3 [Q9VAW5-2] NP_001247347.1, NM_001260418.2 [Q9VAW5-3] NP_001247348.1, NM_001260419.2 [Q9VAW5-3] NP_524998.1, NM_080259.3 [Q9VAW5-2] NP_733244.5, NM_170365.4 [Q9VAW5-3] NP_733245.1, NM_170366.4 [Q9VAW5-2] |
3D structure databases
SMRi | Q9VAW5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 72798, 21 interactors |
IntActi | Q9VAW5, 20 interactors |
MINTi | Q9VAW5 |
STRINGi | 7227.FBpp0290398 |
PTM databases
iPTMneti | Q9VAW5 |
Proteomic databases
PaxDbi | Q9VAW5 |
PRIDEi | Q9VAW5 |
Genome annotation databases
EnsemblMetazoai | FBtr0089680; FBpp0088622; FBgn0261618 [Q9VAW5-2] FBtr0089682; FBpp0088624; FBgn0261618 [Q9VAW5-2] FBtr0301180; FBpp0290398; FBgn0261618 [Q9VAW5-3] FBtr0301181; FBpp0290399; FBgn0261618 [Q9VAW5-2] FBtr0306389; FBpp0297481; FBgn0261618 [Q9VAW5-3] FBtr0306390; FBpp0297482; FBgn0261618 [Q9VAW5-3] |
GeneIDi | 53567 |
KEGGi | dme:Dmel_CG42551 |
UCSCi | CG14066-RB, d. melanogaster |
Organism-specific databases
CTDi | 53567 |
FlyBasei | FBgn0261618, larp |
Phylogenomic databases
eggNOGi | KOG2590, Eukaryota |
GeneTreei | ENSGT00940000169209 |
InParanoidi | Q9VAW5 |
OMAi | GMWKEVK |
PhylomeDBi | Q9VAW5 |
Miscellaneous databases
BioGRID-ORCSi | 53567, 0 hits in 3 CRISPR screens |
ChiTaRSi | larp, fly |
GenomeRNAii | 53567 |
PROi | PR:Q9VAW5 |
Gene expression databases
Bgeei | FBgn0261618, Expressed in pupa and 61 other tissues |
ExpressionAtlasi | Q9VAW5, baseline and differential |
Genevisiblei | Q9VAW5, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR006607, DM15 IPR006630, La_HTH IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit |
SMARTi | View protein in SMART SM00684, DM15, 3 hits SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP_DROME | |
Accessioni | Q9VAW5Primary (citable) accession number: Q9VAW5 Secondary accession number(s): A4V3J4 Q9VAW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | September 21, 2011 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase