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Entry version 168 (07 Oct 2020)
Sequence version 2 (01 Oct 2002)
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Protein

Phosphoglycerate mutase

Gene

Pglym78

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseUniRule annotationARBA annotation
Biological processGlycolysisUniRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695, Neutrophil degranulation
R-DME-70171, Glycolysis
R-DME-70263, Gluconeogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation, EC:5.4.2.4UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pglym78Imported
Synonyms:Dmel\CG1721Imported, PGAMImported, PGLYMImported, PglymImported, pglym78Imported
ORF Names:CG1721Imported, Dmel_CG1721Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014869, Pglym78

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VAN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014869, Expressed in embryo and 28 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VAN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0235, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033323_1_1_1

KEGG Orthology (KO)

More...
KOi
K01834

Identification of Orthologs from Complete Genome Data

More...
OMAi
RMLPYWY

Database of Orthologous Groups

More...
OrthoDBi
804949at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07067, HP_PGM_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1240, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01039, PGAM_GpmA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013078, His_Pase_superF_clade-1
IPR029033, His_PPase_superfam
IPR001345, PG/BPGM_mutase_AS
IPR005952, Phosphogly_mut1

The PANTHER Classification System

More...
PANTHERi
PTHR11931, PTHR11931, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00300, His_Phos_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00855, PGAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53254, SSF53254, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01258, pgm_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00175, PG_MUTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VAN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGKYKIVMV RHGESEWNQK NQFCGWYDAN LSEKGQEEAL AAGKAVKDAG
60 70 80 90 100
LEFDVAHTSV LTRAQVTLAS ILKASGHKEI PIQKTWRLNE RHYGGLTGLN
110 120 130 140 150
KAETAAKYGE AQVQIWRRSF DTPPPPMEPG HPYYENIVKD PRYAEGPKPE
160 170 180 190 200
EFPQFESLKL TIERTLPYWN DVIIPQMKEG KRILIAAHGN SLRGIVKHLD
210 220 230 240 250
NLSEDAIMAL NLPTGIPFVY ELDENFKPVV SMQFLGDEET VKKAIEAVAA

QGKAK
Length:255
Mass (Da):28,573
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13C695AC56516859
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56866.2
AY051464 mRNA Translation: AAK92888.1
AE014297 Genomic DNA Translation: ABC66194.1
AE014297 Genomic DNA Translation: ABC66195.1
DQ864228 Genomic DNA Translation: ABH06863.1
DQ864229 Genomic DNA Translation: ABH06864.1
DQ864230 Genomic DNA Translation: ABH06865.1
DQ864231 Genomic DNA Translation: ABH06866.1
DQ864232 Genomic DNA Translation: ABH06867.1
DQ864233 Genomic DNA Translation: ABH06868.1
DQ864235 Genomic DNA Translation: ABH06870.1
DQ864236 Genomic DNA Translation: ABH06871.1
DQ864243 Genomic DNA Translation: ABH06878.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50326

NCBI Reference Sequences

More...
RefSeqi
NP_001034075.1, NM_001038986.3
NP_001034076.1, NM_001038987.2
NP_524546.2, NM_079822.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085384; FBpp0084753; FBgn0014869
FBtr0100482; FBpp0099919; FBgn0014869
FBtr0100483; FBpp0099920; FBgn0014869

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1721

UCSC genome browser

More...
UCSCi
CG1721-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56866.2
AY051464 mRNA Translation: AAK92888.1
AE014297 Genomic DNA Translation: ABC66194.1
AE014297 Genomic DNA Translation: ABC66195.1
DQ864228 Genomic DNA Translation: ABH06863.1
DQ864229 Genomic DNA Translation: ABH06864.1
DQ864230 Genomic DNA Translation: ABH06865.1
DQ864231 Genomic DNA Translation: ABH06866.1
DQ864232 Genomic DNA Translation: ABH06867.1
DQ864233 Genomic DNA Translation: ABH06868.1
DQ864235 Genomic DNA Translation: ABH06870.1
DQ864236 Genomic DNA Translation: ABH06871.1
DQ864243 Genomic DNA Translation: ABH06878.1
PIRiS50326
RefSeqiNP_001034075.1, NM_001038986.3
NP_001034076.1, NM_001038987.2
NP_524546.2, NM_079822.3

3D structure databases

SMRiQ9VAN7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0084753

Proteomic databases

PRIDEiQ9VAN7

Genome annotation databases

EnsemblMetazoaiFBtr0085384; FBpp0084753; FBgn0014869
FBtr0100482; FBpp0099919; FBgn0014869
FBtr0100483; FBpp0099920; FBgn0014869
GeneIDi43447
KEGGidme:Dmel_CG1721
UCSCiCG1721-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43447
FlyBaseiFBgn0014869, Pglym78

Phylogenomic databases

eggNOGiKOG0235, Eukaryota
GeneTreeiENSGT00950000182926
HOGENOMiCLU_033323_1_1_1
KOiK01834
OMAiRMLPYWY
OrthoDBi804949at2759

Enzyme and pathway databases

ReactomeiR-DME-6798695, Neutrophil degranulation
R-DME-70171, Glycolysis
R-DME-70263, Gluconeogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43447, 1 hit in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43447

Gene expression databases

BgeeiFBgn0014869, Expressed in embryo and 28 other tissues

Family and domain databases

CDDicd07067, HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039, PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078, His_Pase_superF_clade-1
IPR029033, His_PPase_superfam
IPR001345, PG/BPGM_mutase_AS
IPR005952, Phosphogly_mut1
PANTHERiPTHR11931, PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300, His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855, PGAM, 1 hit
SUPFAMiSSF53254, SSF53254, 1 hit
TIGRFAMsiTIGR01258, pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175, PG_MUTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VAN7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VAN7
Secondary accession number(s): Q961P1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: October 7, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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