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Protein

Probable phosphoserine aminotransferase

Gene

CG11899

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphoserine aminotransferase (CG11899)
  3. Phosphoserine phosphatase (aay)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable phosphoserine aminotransferase (CG11899)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40L-glutamateBy similarity1
Binding sitei100Pyridoxal phosphateBy similarity1
Binding sitei149Pyridoxal phosphateBy similarity1
Binding sitei170Pyridoxal phosphateBy similarity1
Binding sitei193Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DME-977347 Serine biosynthesis
UniPathwayiUPA00135; UER00197
UPA00244; UER00311

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoserine aminotransferase (EC:2.6.1.52)
Short name:
PSAT
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Gene namesi
ORF Names:CG11899
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0014427 CG11899

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501391 – 364Probable phosphoserine aminotransferaseAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9VAN0
PRIDEiQ9VAN0

Expressioni

Tissue specificityi

Expressed in ovary and head.1 Publication

Gene expression databases

BgeeiFBgn0014427
GenevisibleiQ9VAN0 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi70214, 8 interactors
DIPiDIP-17047N
IntActiQ9VAN0, 7 interactors
STRINGi7227.FBpp0084759

Structurei

3D structure databases

ProteinModelPortaliQ9VAN0
SMRiQ9VAN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 75Pyridoxal phosphate bindingBy similarity2
Regioni235 – 236Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2790 Eukaryota
COG1932 LUCA
GeneTreeiENSGT00390000015177
InParanoidiQ9VAN0
KOiK00831
OMAiGAQKNMG
OrthoDBiEOG091G0964
PhylomeDBiQ9VAN0

Family and domain databases

CDDicd00611 PSAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00160 SerC_aminotrans_5, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR022278 Pser_aminoTfrase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000525 SerC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01364 serC_1, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VAN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVINFAAGPA KLPEEVLKEV QENLVNCNGS GISVMEMSHR SSNYAKIHDA
60 70 80 90 100
TISDLRELLN VPSNYKILLM QGGGTGQFAA VALNLIGKTG TADYVITGSW
110 120 130 140 150
SAKAAKEAAQ YGTVNAVLPK LAKYTTVPRQ ETWKLDPNAS YVYYCDNETV
160 170 180 190 200
EGVEFDFVPE VPAGVPLVAD MSSNFLSRPF DVSKFGVIYA GAQKNIGPAG
210 220 230 240 250
TTVIIVRDDL IGKHLKITPS ILNFEQMDKN NSLLNTPPTF GIYVMGLVFK
260 270 280 290 300
WIKRNGGVAG MAKLAAAKSK LIYDTINQSN GFYYCPVDVN VRSRMNVPFR
310 320 330 340 350
IGSASGDDAL EKEFLSKAEA EGMIQLKGHR SVGGIRASLY NAVTLAETQQ
360
LANLMLAFYK NNKN
Length:364
Mass (Da):39,540
Last modified:May 1, 2000 - v1
Checksum:iDAEA4E2F5BD4DB74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ062790 mRNA Translation: AAY56663.1
AE014297 Genomic DNA Translation: AAF56874.1
AY119560 mRNA Translation: AAM50214.1
RefSeqiNP_652046.1, NM_143789.3
UniGeneiDm.11354

Genome annotation databases

EnsemblMetazoaiFBtr0085390; FBpp0084759; FBgn0014427
GeneIDi46391
KEGGidme:Dmel_CG11899
UCSCiCG11899-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiSERC_DROME
AccessioniPrimary (citable) accession number: Q9VAN0
Secondary accession number(s): Q3YMT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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