UniProtKB - Q9VAI2 (Q9VAI2_DROME)
Protein
Submitted name:
Kuzbanian-like, isoform A
Gene
Kul
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: FlyBase
GO - Biological processi
- membrane protein ectodomain proteolysis Source: FlyBase
- Notch signaling pathway Source: FlyBase
- positive regulation of Notch signaling pathway Source: FlyBase
Keywordsi
Molecular function | HydrolaseImported |
Protein family/group databases
MEROPSi | M12.322 |
Names & Taxonomyi
Protein namesi | Submitted name: Kuzbanian-like, isoform AImported (EC:3.4.24.-Imported)Submitted name: Kuzbanian-like, isoform BImported |
Gene namesi | ORF Names:CG1964Imported, Dmel_CG1964Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0039688, Kul |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5015100025 | 27 – 1537 | Sequence analysisAdd BLAST | 1511 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotationInteractioni
Protein-protein interaction databases
IntActi | Q9VAI2, 2 interactors |
STRINGi | 7227.FBpp0084826 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 479 – 696 | Peptidase M12BInterPro annotationAdd BLAST | 218 | |
Domaini | 711 – 807 | DisintegrinInterPro annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 286 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 300 – 348 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 1021 – 1062 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1070 – 1089 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1116 – 1148 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1173 – 1207 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 1225 – 1323 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 1336 – 1537 | DisorderedSequence analysisAdd BLAST | 202 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 272 – 286 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1022 – 1038 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1039 – 1062 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1122 – 1148 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1186 – 1207 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1254 – 1323 | PolarSequence analysisAdd BLAST | 70 | |
Compositional biasi | 1336 – 1359 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1369 – 1487 | PolarSequence analysisAdd BLAST | 119 | |
Compositional biasi | 1503 – 1523 | PolarSequence analysisAdd BLAST | 21 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3658, Eukaryota |
HOGENOMi | CLU_003926_0_0_1 |
OMAi | NNGVIVH |
Family and domain databases
CDDi | cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VAI2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWLLGLLGL QVLFLWLLWL PGEILAIPTP LKLPGYTHRL TPYIKHWEAA
60 70 80 90 100
NFDRQVLQAA QVRHLEQARF RQKREVTPSA SGLAHTIRLN FSAHDRDFRL
110 120 130 140 150
VLRQQPHSVF AHDVEIENTL GPIDYDVSRI YTGSLEDDEA AHVQAILTSD
160 170 180 190 200
NLLDGTIETQ AEHYYIEPAH RYSQQLAESG VHSIVYKLSD VNMQKQQFTG
210 220 230 240 250
GGLNSATPAK THCASEKLRK KRWLPEELAM SDAPAPTYNR NPPLPLDLEV
260 270 280 290 300
PYNDDFRVLA SEEDKSEESP RKYPTTSTTR STVRSTESFL ATLTKPTSNR
310 320 330 340 350
NILVNNYNPS NLGEGSRSYS SGNNNANSNS NNNNSNNNNN NNNSNNNVRK
360 370 380 390 400
LYTKHKNIIV STYNRPIEPE FGTPYEEPNN NGTRELPSNF FNANWTTLFL
410 420 430 440 450
GNNNNGNDRP SHKTHVEIIT KNGATKKPNI IVNNYNPEII FAPNPHNPSF
460 470 480 490 500
NSMMMTNLLS GRGGEDIHSS PRLLYDRKTT CMLYLQADHT FFQKMGSDEA
510 520 530 540 550
SIEAITRHVQ RANTIYRNTD FNNDGKPDNI TFMIKRIKVH NMNAMKDPSY
560 570 580 590 600
RFPGNYGVEK FLELFSEEDY DAFCLAYMFT YRDFEMGTLG LAWTGDLKNA
610 620 630 640 650
GGVCEKNGHY RGSLKSLNTG IVTLLNYGKH VPPAVSHVTL AHEIGHNFGS
660 670 680 690 700
PHDPEQCTPG GEDGNFIMFA RATSGDKKNN NKFSTCSLKS IEPVLNAKAR
710 720 730 740 750
SMKGCFTEPQ SSICGNGVVE PGEQCDCGWE EDCKDSCCFP MSRQPRLDET
760 770 780 790 800
PCTLTPHARC SPSQGPCCTT DCKLKFGDKC RDDNGCRDPS FCDGRVPQCP
810 820 830 840 850
PSVNKPNKTI CNKEFVCYMG DCTGSICLAY GLESCQCIPG PQDDRIKSCE
860 870 880 890 900
LCCKLPGEDS PCRSSFEWNE APFDVPDMYS KPGTPCNDYN GYCDVFQKCR
910 920 930 940 950
EVDPSGPLAT LRKLLLSEES IASFKKWMQH NWYTVALAAV GVILLLALST
960 970 980 990 1000
KLLAKRSNLK LKSVTIIHSA TTETVRLPEN NNGVIVHTAV RTKVPFKKKV
1010 1020 1030 1040 1050
RGERTKKPGT GAGVTAAAAV GTRNAAKSSA NPEPKKTTRS QAMAKKKSFE
1060 1070 1080 1090 1100
EEPKKSSKKV GKHMKEIIDY SNRNNNGDDA SNLSTTNNHT NTFGKVQKWL
1110 1120 1130 1140 1150
LESPIVAQPL SHIEHSSRVR KVMSKSQSTP ERLVQKTPQK TKSMGNLSNE
1160 1170 1180 1190 1200
KVKLQVVYKP PFKFSLRLSK KPKVKTHVVG AGVRPKRSQK TSNRTGGQSS
1210 1220 1230 1240 1250
SKEVSTRAKR SALLLCNEAE DDNQILTLNE PNYETLKPPT PPRSMEHCYE
1260 1270 1280 1290 1300
NVDMQAEASS SKPSSSSKVA PSSQNRASLE VTPPVTAQRN SYRRSNSLST
1310 1320 1330 1340 1350
HNPFAAAPRR SSSKASGSVN LTRNFGSTQN LINLSQNLSK NKKRSSLNLK
1360 1370 1380 1390 1400
ASGSGATRSG KDPPTMGVAS PQRRSSSNAN LRRDSSVSSS KAVPVPPTRN
1410 1420 1430 1440 1450
SRNSFSNIPR ASLGGANSNA AVSTGAPPPS FSRQSSSSTA TSSSSITAGV
1460 1470 1480 1490 1500
TSGVALQQSA STSAMQRHPP SQPTRRSLHN FRTRSTGTGA AAGKPGAAVT
1510 1520 1530
SAAATSAGAS SAAASNENNE LPSDLEVVVS DVENLVS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LHU2 | A0A0B4LHU2_DROME | Kuzbanian-like, isoform C | Kul ADAM10, CT3146, Dmel\CG1964, kul, CG1964 | 985 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56926.1 AE014297 Genomic DNA Translation: AHN57588.1 |
RefSeqi | NP_001287589.1, NM_001300660.1 NP_651716.1, NM_143459.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085460; FBpp0084826; FBgn0039688 FBtr0339717; FBpp0308774; FBgn0039688 |
GeneIDi | 43501 |
KEGGi | dme:Dmel_CG1964 |
UCSCi | CG1964-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56926.1 AE014297 Genomic DNA Translation: AHN57588.1 |
RefSeqi | NP_001287589.1, NM_001300660.1 NP_651716.1, NM_143459.3 |
3D structure databases
SMRi | Q9VAI2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VAI2, 2 interactors |
STRINGi | 7227.FBpp0084826 |
Protein family/group databases
MEROPSi | M12.322 |
Genome annotation databases
EnsemblMetazoai | FBtr0085460; FBpp0084826; FBgn0039688 FBtr0339717; FBpp0308774; FBgn0039688 |
GeneIDi | 43501 |
KEGGi | dme:Dmel_CG1964 |
UCSCi | CG1964-RA, d. melanogaster |
Organism-specific databases
CTDi | 43501 |
FlyBasei | FBgn0039688, Kul |
Phylogenomic databases
eggNOGi | KOG3658, Eukaryota |
HOGENOMi | CLU_003926_0_0_1 |
OMAi | NNGVIVH |
Miscellaneous databases
BioGRID-ORCSi | 43501, 0 hits in 1 CRISPR screen |
ChiTaRSi | Kul, fly |
GenomeRNAii | 43501 |
Gene expression databases
Bgeei | FBgn0039688, Expressed in prepupa and 20 other tissues |
Family and domain databases
CDDi | cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VAI2_DROME | |
Accessioni | Q9VAI2Primary (citable) accession number: Q9VAI2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |