UniProtKB - Q9VA71 (Q9VA71_DROME)
Protein
Submitted name:
FI19924p1
Gene
Q9VA71
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- isopeptidase activity Source: InterPro
- Lys63-specific deubiquitinase activity Source: GO_Central
- metallopeptidase activity Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: GO_Central
GO - Biological processi
- protein deubiquitination Source: FlyBase
- protein K63-linked deubiquitination Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
Reactomei | R-DME-5689901, Metalloprotease DUBs |
Protein family/group databases
MEROPSi | M67.A09 |
Names & Taxonomyi
Protein namesi | Submitted name: FI19924p1ImportedSubmitted name: Uncharacterized protein, isoform AImportedSubmitted name: Uncharacterized protein, isoform BImported |
Gene namesi | Name:Q9VA71Imported Synonyms:AMSHImported, AmshImported, CG2224-RAImported, Dmel\CG2224Imported ORF Names:CG2224Imported, Dmel_CG2224Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0039773, CG2224 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | FBgn0039773, Expressed in imaginal disc and 34 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q9VA71, 4 interactors |
STRINGi | 7227.FBpp0303776 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 250 – 378 | MPNInterPro annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 159 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 214 – 236 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 132 – 155 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 217 – 236 | PolarSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the peptidase M67C family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG2880, Eukaryota |
GeneTreei | ENSGT00940000153710 |
HOGENOMi | CLU_023304_0_1_1 |
OMAi | CNTMHEE |
OrthoDBi | 411229at2759 |
Family and domain databases
CDDi | cd08066, MPN_AMSH_like, 1 hit |
InterProi | View protein in InterPro IPR000555, JAMM/MPN+_dom IPR037518, MPN IPR044098, STAMBP/STALP-like_MPN IPR015063, USP8_dimer |
Pfami | View protein in Pfam PF01398, JAB, 1 hit PF08969, USP8_dimer, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VA71-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKAVNNMSM GDVEPQERMK HLSHCGNLIE VDKNMPVTRY YRSGTEMLRM
60 70 80 90 100
ANVYLREGNH ENAFILYLRY MTLFIEKIRQ HPDYGSVKAE VRDINRKIKD
110 120 130 140 150
EIMPTTEKLR AKLLTHYQRE YEQFLASKEA ERVKELERER ERERERQRQK
160 170 180 190 200
EREKAGSSAI PSLIPANLHV LIDEGNQPSA PDLGLLDQVV YPNDFPTGAN
210 220 230 240 250
RSLPGSGLLL PAASEAAADK TTNSKPSFDR NQKPSYNRTD SLLAGSLRLV
260 270 280 290 300
YVPGDTMEVF LKLALANTSK NIETCGVLAG HLSQNQLYIT HIITPQQQGT
310 320 330 340 350
PDSCNTMHEE QIFDVQDQMQ LITLGWIHTH PTQTAFLSSV DLHTHCSYQI
360 370 380 390 400
MMPEALAIVC APKYNTTGFF ILTPHYGLDY IAQCRQSGFH PHPNDPPLFM
410 420
EAQHIRMDNQ AKIKVIDLRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57051.1 BT133327 mRNA Translation: AFE85380.1 AE014297 Genomic DNA Translation: AGB96487.1 |
RefSeqi | NP_001263108.1, NM_001276179.1 NP_651796.1, NM_143539.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085691; FBpp0085053; FBgn0039773 FBtr0331358; FBpp0303776; FBgn0039773 |
GeneIDi | 43617 |
KEGGi | dme:Dmel_CG2224 |
UCSCi | CG2224-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57051.1 BT133327 mRNA Translation: AFE85380.1 AE014297 Genomic DNA Translation: AGB96487.1 |
RefSeqi | NP_001263108.1, NM_001276179.1 NP_651796.1, NM_143539.3 |
3D structure databases
SMRi | Q9VA71 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VA71, 4 interactors |
STRINGi | 7227.FBpp0303776 |
Protein family/group databases
MEROPSi | M67.A09 |
Genome annotation databases
EnsemblMetazoai | FBtr0085691; FBpp0085053; FBgn0039773 FBtr0331358; FBpp0303776; FBgn0039773 |
GeneIDi | 43617 |
KEGGi | dme:Dmel_CG2224 |
UCSCi | CG2224-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0039773, CG2224 |
Phylogenomic databases
eggNOGi | KOG2880, Eukaryota |
GeneTreei | ENSGT00940000153710 |
HOGENOMi | CLU_023304_0_1_1 |
OMAi | CNTMHEE |
OrthoDBi | 411229at2759 |
Enzyme and pathway databases
Reactomei | R-DME-5689901, Metalloprotease DUBs |
Miscellaneous databases
BioGRID-ORCSi | 43617, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43617 |
Gene expression databases
Bgeei | FBgn0039773, Expressed in imaginal disc and 34 other tissues |
Family and domain databases
CDDi | cd08066, MPN_AMSH_like, 1 hit |
InterProi | View protein in InterPro IPR000555, JAMM/MPN+_dom IPR037518, MPN IPR044098, STAMBP/STALP-like_MPN IPR015063, USP8_dimer |
Pfami | View protein in Pfam PF01398, JAB, 1 hit PF08969, USP8_dimer, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VA71_DROME | |
Accessioni | Q9VA71Primary (citable) accession number: Q9VA71 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |