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UniProtKB - Q9VA27 (CP4C3_DROME)
Protein
Cytochrome P450 4c3
Gene
Cyp4c3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 342 | Heme; covalent, via 1 linkBy similarity | 1 | |
Metal bindingi | 481 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp4c3 ORF Names:CG1438 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0015032, Cyp4c3 |
VEuPathDBi | VectorBase:FBgn0015032 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051831 | 1 – 535 | Cytochrome P450 4c3Add BLAST | 535 |
Proteomic databases
PaxDbi | Q9VA27 |
PRIDEi | Q9VA27 |
Expressioni
Gene expression databases
Bgeei | FBgn0015032, Expressed in head and 20 other tissues |
Genevisiblei | Q9VA27, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q9VA27, 4 interactors |
STRINGi | 7227.FBpp0085074 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9VA27 |
OMAi | IQPAFHK |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q9VA27 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VA27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKVITSLM AESILLSKVG QVISGYSPIT VFLLGSILIF LVVYNKRRSR
60 70 80 90 100
LVKYIEKIPG PAAMPFLGNA IEMNVDHDEL FNRVIGMQKL WGTRIGINRV
110 120 130 140 150
WQGTAPRVLL FEPETVEPIL NSQKFVNKSH DYDYLHPWLG EGLLTSTDRK
160 170 180 190 200
WHSRRKILTP AFHFKILDDF IDVFNEQSAV LARKLAVEVG SEAFNLFPYV
210 220 230 240 250
TLCTLDIVCE TAMGRRIYAQ SNSESEYVKA VYGIGSIVQS RQAKIWLQSD
260 270 280 290 300
FIFSLTAEYK LHQSYINTLH GFSNMVIRER KAELAILQEN NNNNNNNAPD
310 320 330 340 350
AYDDVGKKKR LAFLDLLIDA SKEGTVLSNE DIREEVDTFM FEGHDTTSAA
360 370 380 390 400
ISWTLFLLGC HPEYQERVVE ELDSIFGDDK ETPATMKNLM DMRYLECCIK
410 420 430 440 450
DSLRLFPSVP MMARMVGEDV NIGGKIVPAG TQAIIMTYAL HRNPRVFPKP
460 470 480 490 500
EQFNPDNFLP ENCAGRHPFA YIPFSAGPRN CIGQKFAILE EKAVISTVLR
510 520 530
KYKIEAVDRR EDLTLLGELI LRPKDGLRVK ITPRD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57098.1 BT010108 mRNA Translation: AAQ22577.1 U34323 mRNA Translation: AAA80657.1 |
RefSeqi | NP_524598.1, NM_079859.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0085712; FBpp0085074; FBgn0015032 |
GeneIDi | 43663 |
KEGGi | dme:Dmel_CG1438 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57098.1 BT010108 mRNA Translation: AAQ22577.1 U34323 mRNA Translation: AAA80657.1 |
RefSeqi | NP_524598.1, NM_079859.4 |
3D structure databases
SMRi | Q9VA27 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VA27, 4 interactors |
STRINGi | 7227.FBpp0085074 |
Proteomic databases
PaxDbi | Q9VA27 |
PRIDEi | Q9VA27 |
Protocols and materials databases
DNASUi | 43663 |
Genome annotation databases
EnsemblMetazoai | FBtr0085712; FBpp0085074; FBgn0015032 |
GeneIDi | 43663 |
KEGGi | dme:Dmel_CG1438 |
Organism-specific databases
CTDi | 43663 |
FlyBasei | FBgn0015032, Cyp4c3 |
VEuPathDBi | VectorBase:FBgn0015032 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9VA27 |
OMAi | IQPAFHK |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q9VA27 |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Miscellaneous databases
BioGRID-ORCSi | 43663, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43663 |
PROi | PR:Q9VA27 |
Gene expression databases
Bgeei | FBgn0015032, Expressed in head and 20 other tissues |
Genevisiblei | Q9VA27, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP4C3_DROME | |
Accessioni | Q9VA27Primary (citable) accession number: Q9VA27 Secondary accession number(s): Q24121 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families