UniProtKB - Q9V9V7 (Q9V9V7_DROME)
Protein
Submitted name:
LD23072p
Gene
pasha
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- double-stranded RNA binding Source: FlyBase
- heme binding Source: GO_Central
- identical protein binding Source: InterPro
- primary miRNA binding Source: GO_Central
GO - Biological processi
- gene silencing by miRNA Source: FlyBase
- germarium-derived female germ-line cyst formation Source: FlyBase
- germarium-derived oocyte fate determination Source: FlyBase
- imaginal disc growth Source: FlyBase
- mushroom body development Source: FlyBase
- primary miRNA processing Source: FlyBase
- RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: LD23072pImportedSubmitted name: Partner of drosha, isoform AImportedSubmitted name: Partner of drosha, isoform CImported |
Gene namesi | Name:pashaImported Synonyms:cg1800Imported, DGCR8Imported, dmDGCR8Imported, Dmel\CG1800Imported, PASHAImported, PashaImported ORF Names:CG1800Imported, Dmel_CG1800Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0039861, pasha |
Subcellular locationi
Nucleus
- microprocessor complex Source: WormBase
- nucleus Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0039861, Expressed in Malpighian tubule and 35 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: InterPro
Protein-protein interaction databases
IntActi | Q9V9V7, 4 interactors |
STRINGi | 7227.FBpp0085181 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 369 – 436 | DRBMInterPro annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 42 – 112 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 93 – 112 | AcidicSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | KOG4334, Eukaryota |
GeneTreei | ENSGT00390000015977 |
OMAi | MMENRAC |
OrthoDBi | 855874at2759 |
Family and domain databases
CDDi | cd00048, DSRM, 1 hit |
InterProi | View protein in InterPro IPR040375, DGCR8 IPR014720, dsRBD_dom |
PANTHERi | PTHR13482, PTHR13482, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 1 hit |
SMARTi | View protein in SMART SM00358, DSRM, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9V9V7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKPLADCP DSGQVRKRPR LEDEEQELKV AGFSLSAIEE MRRTRDNELQ
60 70 80 90 100
NEPMDQQLRQ FQVLDEVGSG SDEDDESDNA SEQQGGRYGE GGDEEEEAAD
110 120 130 140 150
GDGEEYDSSE FDDDEIENLL DEKLPEELRE SKQPKYEQRF KTVLEEKRLN
160 170 180 190 200
HFEVLPEGWV QVTHNSGMPL FLHRKTRVCC ASRPYFLGTG SARKHAVPLG
210 220 230 240 250
AIPCLNYRRA LEEESEVEQQ KTDGAPPVAV CPMAGASALP AEAMDVEGKE
260 270 280 290 300
NNEGSTDSKT QPDGITALMP AAKIVTVNEN TQKESITPEQ LNTYCQKLFK
310 320 330 340 350
FKVIRVLRFR SWNARRKFTK NRKHIKNIQR PTLPDGTKLI KFPILANAGE
360 370 380 390 400
GSTNPRGRKE WIMNPNGKSF VCILHEYVQH ALKTQPTYEF KELQNAATPY
410 420 430 440 450
SATVSVNNLK YGTGYGTSKK QAKSEAARET LEILIPDVKD KITGNNKDQK
460 470 480 490 500
SGTAKKAQSD LSVFDDIRIE DPRVTEFCNK TTEPSPNAIL LTCLQRNYGS
510 520 530 540 550
DVQISQEINR TANNKNEFTM TVGKHTAKVV CKNKREGKQL ASQAILQILH
560 570 580 590 600
PHIQTWGSLL RLYGNNSIKT FKEKKLEEQE ITVLQSKAAV NQPNYAILDK
610 620 630 640
LKSEMLKLCA KQESVLTMGT FVPPSDVDLP TSSGSNLNNV EL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KI70 | A0A0B4KI70_DROME | Partner of drosha, isoform B | pasha cg1800, DGCR8, dmDGCR8, Dmel\CG1800, PASHA | 580 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57175.1 AY058524 mRNA Translation: AAL13753.1 AE014297 Genomic DNA Translation: AGB96528.1 |
RefSeqi | NP_001263150.1, NM_001276221.1 NP_651879.1, NM_143622.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085820; FBpp0085181; FBgn0039861 FBtr0337032; FBpp0307961; FBgn0039861 |
GeneIDi | 43728 |
UCSCi | CG1800-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF57175.1 AY058524 mRNA Translation: AAL13753.1 AE014297 Genomic DNA Translation: AGB96528.1 |
RefSeqi | NP_001263150.1, NM_001276221.1 NP_651879.1, NM_143622.3 |
3D structure databases
SMRi | Q9V9V7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9V9V7, 4 interactors |
STRINGi | 7227.FBpp0085181 |
Protocols and materials databases
ABCDi | Q9V9V7, 1 sequenced antibody |
Genome annotation databases
EnsemblMetazoai | FBtr0085820; FBpp0085181; FBgn0039861 FBtr0337032; FBpp0307961; FBgn0039861 |
GeneIDi | 43728 |
UCSCi | CG1800-RA, d. melanogaster |
Organism-specific databases
CTDi | 43728 |
FlyBasei | FBgn0039861, pasha |
Phylogenomic databases
eggNOGi | KOG4334, Eukaryota |
GeneTreei | ENSGT00390000015977 |
OMAi | MMENRAC |
OrthoDBi | 855874at2759 |
Miscellaneous databases
BioGRID-ORCSi | 43728, 0 hits in 1 CRISPR screen |
GenomeRNAii | 43728 |
PROi | PR:Q9V9V7 |
Gene expression databases
Bgeei | FBgn0039861, Expressed in Malpighian tubule and 35 other tissues |
Family and domain databases
CDDi | cd00048, DSRM, 1 hit |
InterProi | View protein in InterPro IPR040375, DGCR8 IPR014720, dsRBD_dom |
PANTHERi | PTHR13482, PTHR13482, 1 hit |
Pfami | View protein in Pfam PF00035, dsrm, 1 hit |
SMARTi | View protein in SMART SM00358, DSRM, 1 hit |
PROSITEi | View protein in PROSITE PS50137, DS_RBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9V9V7_DROME | |
Accessioni | Q9V9V7Primary (citable) accession number: Q9V9V7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |