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UniProtKB - Q9V9L1 (CP6W1_DROME)
Protein
Probable cytochrome P450 6w1
Gene
Cyp6w1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 450 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
GO - Biological processi
- insecticide catabolic process Source: GO_Central
- response to DDT Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp6w1 ORF Names:CG8345 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033065, Cyp6w1 |
VEuPathDBi | VectorBase:FBgn0033065 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051892 | 1 – 514 | Probable cytochrome P450 6w1Add BLAST | 514 |
Proteomic databases
PaxDbi | Q9V9L1 |
PRIDEi | Q9V9L1 |
Expressioni
Gene expression databases
Bgeei | FBgn0033065, Expressed in antenna and 35 other tissues |
ExpressionAtlasi | Q9V9L1, baseline and differential |
Genevisiblei | Q9V9L1, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 61446, 1 interactor |
STRINGi | 7227.FBpp0085332 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000167661 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9V9L1 |
OMAi | PFHNMEL |
OrthoDBi | 786853at2759 |
PhylomeDBi | Q9V9L1 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9V9L1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLLLLGSL TIVFYIWQRR TLSFWERHGV KYIRPFPVVG CTREFLTAKV
60 70 80 90 100
PFFEQIQKFH EAPGFENEPF VGVYMTHRPA LVIRDLELIK TVMIKKFQYF
110 120 130 140 150
NNRVLQTDPH NDALGYKNLF FARSPGWREL RTKISPVFTS GKIKQMYPLM
160 170 180 190 200
VKIGKNLQDS AERLGSGTEV QVKDLCSRFT TDLIATIAFG VEANALQDAK
210 220 230 240 250
SEFFYHNRAI FSLTLSRGID FAIIFMIPAL ASLARVKLFS RETTKFIRSS
260 270 280 290 300
VNYVLKERER TGEKRNDLID ILLALKREAA ANPGKMSKEV DLDYLVAQAA
310 320 330 340 350
VFQTAGFETS ASTMTMTLYE LAKNEALQDR LRQEIVDFFG DEDHISYERI
360 370 380 390 400
QEMPYLSQVV NETLRKYPIV GYIERECSQP AEGERFTLEP FHNMELPHGM
410 420 430 440 450
SIYMSTVAVH RDPQYWPDPE KYDPERFNSS NRDNLNMDAY MPFGVGPRNC
460 470 480 490 500
IGMRLGLLQS KLGLVHILRN HRFHTCDKTI KKIEWAPTSP VMASKRDIIL
510
RVEKVSGKKD FGQK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LEU2 | A0A0B4LEU2_DROME | Cyp6w1, isoform B | Cyp6w1 6w1, AntP450, CYP6W1, CYP6w1, Cyp6W1 | 514 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57277.1 AY069121 mRNA Translation: AAL39266.1 |
RefSeqi | NP_001286145.1, NM_001299216.1 NP_610206.1, NM_136362.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085987; FBpp0085332; FBgn0033065 FBtr0345485; FBpp0311596; FBgn0033065 |
GeneIDi | 35543 |
KEGGi | dme:Dmel_CG8345 |
UCSCi | CG8345-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57277.1 AY069121 mRNA Translation: AAL39266.1 |
RefSeqi | NP_001286145.1, NM_001299216.1 NP_610206.1, NM_136362.3 |
3D structure databases
AlphaFoldDBi | Q9V9L1 |
SMRi | Q9V9L1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 61446, 1 interactor |
STRINGi | 7227.FBpp0085332 |
Proteomic databases
PaxDbi | Q9V9L1 |
PRIDEi | Q9V9L1 |
Genome annotation databases
EnsemblMetazoai | FBtr0085987; FBpp0085332; FBgn0033065 FBtr0345485; FBpp0311596; FBgn0033065 |
GeneIDi | 35543 |
KEGGi | dme:Dmel_CG8345 |
UCSCi | CG8345-RA, d. melanogaster |
Organism-specific databases
CTDi | 35543 |
FlyBasei | FBgn0033065, Cyp6w1 |
VEuPathDBi | VectorBase:FBgn0033065 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000167661 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | Q9V9L1 |
OMAi | PFHNMEL |
OrthoDBi | 786853at2759 |
PhylomeDBi | Q9V9L1 |
Miscellaneous databases
BioGRID-ORCSi | 35543, 0 hits in 1 CRISPR screen |
ChiTaRSi | Cyp6w1, fly |
GenomeRNAii | 35543 |
PROi | PR:Q9V9L1 |
Gene expression databases
Bgeei | FBgn0033065, Expressed in antenna and 35 other tissues |
ExpressionAtlasi | Q9V9L1, baseline and differential |
Genevisiblei | Q9V9L1, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP6W1_DROME | |
Accessioni | Q9V9L1Primary (citable) accession number: Q9V9L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families