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UniProtKB - Q9V8M5 (3HIDH_DROME)
Protein
Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
Gene
CG15093
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:1.1.1.31
: L-valine degradation Pathwayi
This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 121 | NAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 196 | By similarity | 1 | |
Binding sitei | 271 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 58 | NADBy similarityAdd BLAST | 30 | |
Nucleotide bindingi | 92 – 93 | NADBy similarity | 2 |
GO - Molecular functioni
- 3-hydroxyisobutyrate dehydrogenase activity Source: FlyBase
- NAD binding Source: InterPro
- NADP binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
GO - Biological processi
- valine catabolic process Source: FlyBase
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Branched-chain amino acid catabolism |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-DME-70895, Branched-chain amino acid catabolism |
UniPathwayi | UPA00362 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (EC:1.1.1.31)Short name: HIBADH |
Gene namesi | ORF Names:CG15093 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034390, CG15093 |
VEuPathDBi | VectorBase:FBgn0034390 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: FlyBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 25 | MitochondrionBy similarityAdd BLAST | 25 | |
ChainiPRO_0000007161 | 26 – 324 | Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrialAdd BLAST | 299 |
Proteomic databases
PaxDbi | Q9V8M5 |
PeptideAtlasi | Q9V8M5 |
PRIDEi | Q9V8M5 |
Expressioni
Gene expression databases
Bgeei | FBgn0034390, Expressed in larva and 20 other tissues |
ExpressionAtlasi | Q9V8M5, baseline and differential |
Genevisiblei | Q9V8M5, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 62836, 1 interactor |
DIPi | DIP-22109N |
IntActi | Q9V8M5, 1 interactor |
STRINGi | 7227.FBpp0085821 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0409, Eukaryota |
GeneTreei | ENSGT00940000173744 |
HOGENOMi | CLU_035117_6_0_1 |
InParanoidi | Q9V8M5 |
OMAi | WSSEVNN |
OrthoDBi | 812358at2759 |
PhylomeDBi | Q9V8M5 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR002204, 3-OH-isobutyrate_DH-rel_CS IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR011548, HIBADH IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01692, HIBADH, 1 hit |
PROSITEi | View protein in PROSITE PS00895, 3_HYDROXYISOBUT_DH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9V8M5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLRVMSPAM LNAWSQTLVR AMSTQGGAKN IGFVGLGNMG ANMASNLIKA
60 70 80 90 100
GHKLHVFDIS KPACDGLAAK GATVYAKTSE LAKNSDFVIT MLPNNAIVDA
110 120 130 140 150
SYDEMTADGV NKDTIFIDSS TISPDLVKSL QKKISAKGAR FIDAPVSGGV
160 170 180 190 200
PGAEQATLTF MVGGTEAEYN AVKAVLECMG KKITHCGVYG MGQAAKLCNN
210 220 230 240 250
MMLAISMIGV SEAMNLAVRQ GLDANVFAEI INSSTGRCWA SEIYNPVPGV
260 270 280 290 300
CPSAPANRDY AGGFSSALIT KDLGLASGVA NASNSPIPLG SLAHKVYQSL
310 320
CDKGLGNKDF SVVYDLMKKE KFSV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4JCU8 | A0A0B4JCU8_DROME | 3-hydroxyisobutyrate dehydrogenase | Dmel\CG15093 CG 15093, CT34968, CG15093, Dmel_CG15093 | 324 | Annotation score: |
Sequence cautioni
The sequence AAL39202 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57639.2 AY069057 mRNA Translation: AAL39202.2 Different initiation. |
RefSeqi | NP_001188972.1, NM_001202043.2 NP_611373.1, NM_137529.4 NP_725824.1, NM_166306.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0086639; FBpp0085821; FBgn0034390 FBtr0086640; FBpp0085822; FBgn0034390 FBtr0303846; FBpp0292854; FBgn0034390 |
GeneIDi | 37166 |
KEGGi | dme:Dmel_CG15093 |
UCSCi | CG15093-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57639.2 AY069057 mRNA Translation: AAL39202.2 Different initiation. |
RefSeqi | NP_001188972.1, NM_001202043.2 NP_611373.1, NM_137529.4 NP_725824.1, NM_166306.3 |
3D structure databases
SMRi | Q9V8M5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62836, 1 interactor |
DIPi | DIP-22109N |
IntActi | Q9V8M5, 1 interactor |
STRINGi | 7227.FBpp0085821 |
Proteomic databases
PaxDbi | Q9V8M5 |
PeptideAtlasi | Q9V8M5 |
PRIDEi | Q9V8M5 |
Protocols and materials databases
DNASUi | 37166 |
Genome annotation databases
EnsemblMetazoai | FBtr0086639; FBpp0085821; FBgn0034390 FBtr0086640; FBpp0085822; FBgn0034390 FBtr0303846; FBpp0292854; FBgn0034390 |
GeneIDi | 37166 |
KEGGi | dme:Dmel_CG15093 |
UCSCi | CG15093-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0034390, CG15093 |
VEuPathDBi | VectorBase:FBgn0034390 |
Phylogenomic databases
eggNOGi | KOG0409, Eukaryota |
GeneTreei | ENSGT00940000173744 |
HOGENOMi | CLU_035117_6_0_1 |
InParanoidi | Q9V8M5 |
OMAi | WSSEVNN |
OrthoDBi | 812358at2759 |
PhylomeDBi | Q9V8M5 |
Enzyme and pathway databases
UniPathwayi | UPA00362 |
Reactomei | R-DME-70895, Branched-chain amino acid catabolism |
Miscellaneous databases
BioGRID-ORCSi | 37166, 0 hits in 1 CRISPR screen |
ChiTaRSi | CG15093, fly |
GenomeRNAii | 37166 |
PROi | PR:Q9V8M5 |
Gene expression databases
Bgeei | FBgn0034390, Expressed in larva and 20 other tissues |
ExpressionAtlasi | Q9V8M5, baseline and differential |
Genevisiblei | Q9V8M5, DM |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR002204, 3-OH-isobutyrate_DH-rel_CS IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR011548, HIBADH IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01692, HIBADH, 1 hit |
PROSITEi | View protein in PROSITE PS00895, 3_HYDROXYISOBUT_DH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 3HIDH_DROME | |
Accessioni | Q9V8M5Primary (citable) accession number: Q9V8M5 Secondary accession number(s): Q0E926, Q86R98, Q9V8M6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | January 24, 2001 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families