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UniProtKB - Q9V8M2 (C12B2_DROME)
Protein
Probable cytochrome P450 12b2, mitochondrial
Gene
Cyp12b2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 479 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable cytochrome P450 12b2, mitochondrial (EC:1.14.-.-)Alternative name(s): CYPXIIB2 |
Gene namesi | Name:Cyp12b2 ORF Names:CG15077 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034387, Cyp12b2 |
VEuPathDBi | VectorBase:FBgn0034387 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane Curated
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000003611 | ? – 535 | Probable cytochrome P450 12b2, mitochondrial |
Proteomic databases
PaxDbi | Q9V8M2 |
PRIDEi | Q9V8M2 |
Expressioni
Gene expression databases
Bgeei | FBgn0034387, Expressed in mouthpart (Drosophila) and 32 other tissues |
Genevisiblei | Q9V8M2, DM |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0159, Eukaryota |
GeneTreei | ENSGT00940000165868 |
HOGENOMi | CLU_001570_28_0_1 |
InParanoidi | Q9V8M2 |
OMAi | NLIQMNR |
OrthoDBi | 871849at2759 |
PhylomeDBi | Q9V8M2 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9V8M2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWKYSNKIIY RNVSGNQLWF NRNSSVGGTL SQQTQLELAD SRIDEKWQQA
60 70 80 90 100
RSFGEIPGPS LLRMLSFFMP GGALRNTNLI QMNRLMREMY GDIYCIPGMM
110 120 130 140 150
GKPNAVFTYN PDDFEMTYRN EGVWPIRIGL ESLNYYRKIH RPDVFKGVGG
160 170 180 190 200
LASDQGQEWA DIRNKVNPVL MKVQNVRQNL PQLDQISKEF IDKLETQRNP
210 220 230 240 250
ETHTLTTDFH NQLKMWAFES ISFVALNTRM GLLSDNPDPN ADRLAKHMRD
260 270 280 290 300
FFNYSFQFDV QPSIWTFYKT AGFKKFLKTY DNITDITSNY IETAMRGFGK
310 320 330 340 350
NDDGKTKCVL EQLLEHNKKV AVTMVMDMLM AGIDTTSSAC LTILYHLARN
360 370 380 390 400
PSKQEKLRRE LLRILPTTKD SLTDQNTKNM PYLRACIKEG LRITSITPGN
410 420 430 440 450
FRITPKDLVL SGYQVPRGTG VLMGVLELSN DDKYFAQSSE FIPERWLKSD
460 470 480 490 500
LAPDIQACPA ARTRNPFVYL PFGFGPRTCI GKRIAELEIE TLLVRLLRSY
510 520 530
KVSWLPETPI EYESTIILSP CGDIRFKLEP VGDLM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57642.2 BT023132 mRNA Translation: AAY55548.1 |
RefSeqi | NP_611370.2, NM_137526.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0086609; FBpp0085792; FBgn0034387 |
GeneIDi | 37163 |
KEGGi | dme:Dmel_CG15077 |
UCSCi | CG15077-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57642.2 BT023132 mRNA Translation: AAY55548.1 |
RefSeqi | NP_611370.2, NM_137526.3 |
3D structure databases
SMRi | Q9V8M2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0085792 |
Proteomic databases
PaxDbi | Q9V8M2 |
PRIDEi | Q9V8M2 |
Genome annotation databases
EnsemblMetazoai | FBtr0086609; FBpp0085792; FBgn0034387 |
GeneIDi | 37163 |
KEGGi | dme:Dmel_CG15077 |
UCSCi | CG15077-RA, d. melanogaster |
Organism-specific databases
CTDi | 37163 |
FlyBasei | FBgn0034387, Cyp12b2 |
VEuPathDBi | VectorBase:FBgn0034387 |
Phylogenomic databases
eggNOGi | KOG0159, Eukaryota |
GeneTreei | ENSGT00940000165868 |
HOGENOMi | CLU_001570_28_0_1 |
InParanoidi | Q9V8M2 |
OMAi | NLIQMNR |
OrthoDBi | 871849at2759 |
PhylomeDBi | Q9V8M2 |
Miscellaneous databases
BioGRID-ORCSi | 37163, 0 hits in 3 CRISPR screens |
GenomeRNAii | 37163 |
PROi | PR:Q9V8M2 |
Gene expression databases
Bgeei | FBgn0034387, Expressed in mouthpart (Drosophila) and 32 other tissues |
Genevisiblei | Q9V8M2, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C12B2_DROME | |
Accessioni | Q9V8M2Primary (citable) accession number: Q9V8M2 Secondary accession number(s): Q4V474 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | April 14, 2009 | |
Last modified: | September 29, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families