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UniProtKB - Q9V8K2 (EXOC3_DROME)
Protein
Exocyst complex component 3
Gene
Sec6
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
GO - Molecular functioni
- SNARE binding Source: FlyBase
GO - Biological processi
- border follicle cell migration Source: FlyBase
- endocytic recycling Source: FlyBase
- exocyst localization Source: GO_Central
- exocytosis Source: FlyBase
- Golgi to plasma membrane protein transport Source: FlyBase
- neurotransmitter secretion Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- plasma membrane organization Source: FlyBase
- protein localization to cell cortex Source: FlyBase
- protein localization to plasma membrane Source: FlyBase
- rhabdomere membrane biogenesis Source: FlyBase
- synaptic vesicle docking Source: FlyBase
- synaptic vesicle targeting Source: FlyBase
- vesicle-mediated transport Source: FlyBase
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-DME-264876, Insulin processing R-DME-5620916, VxPx cargo-targeting to cilium |
SignaLinki | Q9V8K2 |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component 3Alternative name(s): Exocyst complex component Sec6 |
Gene namesi | Name:Sec6Imported ORF Names:CG5341Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0266671, Sec6 |
VEuPathDBi | VectorBase:FBgn0266671 |
Subcellular locationi
Other locations
- cytoplasm Source: FlyBase
- exocyst Source: FlyBase
- membrane Source: FlyBase
- presynapse Source: GOC
- rhabdomere Source: FlyBase
- zonula adherens Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118929 | 1 – 738 | Exocyst complex component 3Add BLAST | 738 |
Proteomic databases
PaxDbi | Q9V8K2 |
PRIDEi | Q9V8K2 |
Expressioni
Gene expression databases
Bgeei | FBgn0266671, Expressed in embryonic/larval hemocyte (Drosophila) and 44 other tissues |
Genevisiblei | Q9V8K2, DM |
Interactioni
Subunit structurei
The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.
By similarityGO - Molecular functioni
- SNARE binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 62816, 29 interactors |
DIPi | DIP-18668N |
IntActi | Q9V8K2, 4 interactors |
STRINGi | 7227.FBpp0085888 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 28 – 91 | Sequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the SEC6 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2286, Eukaryota |
GeneTreei | ENSGT01030000234613 |
HOGENOMi | CLU_016260_1_0_1 |
InParanoidi | Q9V8K2 |
OMAi | MNIGPKT |
OrthoDBi | 391172at2759 |
PhylomeDBi | Q9V8K2 |
Family and domain databases
Gene3Di | 1.10.357.70, 1 hit |
InterProi | View protein in InterPro IPR010326, EXOC3/Sec6 IPR042532, EXOC3/Sec6_C |
PANTHERi | PTHR21292, PTHR21292, 1 hit |
Pfami | View protein in Pfam PF06046, Sec6, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9V8K2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLQQLEEQA RQAALKDIQN MLQRPGQLEK VEQYRHRIAR KKASVEALLK
60 70 80 90 100
TGMQGQLDGV RVGLKQLETC MQDVREVRRR MDEVERLLRG VPEVYDALEV
110 120 130 140 150
VREENTKHSQ YATAMENLKH IFNVDASVQK TMALIEDDKL LNAHQCLADL
160 170 180 190 200
ENSRDDLLYE LHKQPKQHAS DKITLKRHFE KVDTVSQELE KKLRLILSRT
210 220 230 240 250
LNTLRKKPTI IVTALRIIER EEKNDQFALQ QQKVTGFLPP GRPKAWRRMI
260 270 280 290 300
MDVLQQSVIT RIEGSKLEER ADNKMWLVRD LEILRQIILE DLRVVKSLCV
310 320 330 340 350
PCFPPHYDIF GEYVKFYHEG LSSYLDNIVR SGLEGNEYVS MMAWVTHTYP
360 370 380 390 400
GVELMSHPDL NVDVHRQIGT LLRPEHLKAL EDEYLQNMQR NFQEWMTKAA
410 420 430 440 450
ETEKQEWFTE TVPDQDEEYY HTSAPVIIFQ MIDQHLQVTN TIHQELTFKA
460 470 480 490 500
LVMSIQQVEI FGQTYLKNVI ELKEHHFRNR DQIKYFTHYI ITIVNNSQQM
510 520 530 540 550
VELAQQMKQL YWPKSRTEHY EDFERLLATF QRIRAHAASY LLEEAFLDME
560 570 580 590 600
CHFNDLFTAK WLASNIAVDT ICVTLDDYFQ DYNHLRPNNF EMVINEAQKL
610 620 630 640 650
LAKRYIRALL SKRLSKPRAE CDAITRKIKT EAKRFKLFFE KIAPKISLSD
660 670 680 690 700
SPLDLISTLS ALLSSDIELL VLDLHTLLGS YPSLNEDHLV RLFYIRNDVK
710 720 730
AAEVREKVQD AMKSKKAMVS IAKQDCIFKE IVFSDKLW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57664.2 AY058549 mRNA Translation: AAL13778.1 |
RefSeqi | NP_611351.1, NM_137507.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0086709; FBpp0085888; FBgn0266671 |
GeneIDi | 37142 |
KEGGi | dme:Dmel_CG5341 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57664.2 AY058549 mRNA Translation: AAL13778.1 |
RefSeqi | NP_611351.1, NM_137507.5 |
3D structure databases
SMRi | Q9V8K2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62816, 29 interactors |
DIPi | DIP-18668N |
IntActi | Q9V8K2, 4 interactors |
STRINGi | 7227.FBpp0085888 |
Proteomic databases
PaxDbi | Q9V8K2 |
PRIDEi | Q9V8K2 |
Protocols and materials databases
DNASUi | 37142 |
Genome annotation databases
EnsemblMetazoai | FBtr0086709; FBpp0085888; FBgn0266671 |
GeneIDi | 37142 |
KEGGi | dme:Dmel_CG5341 |
Organism-specific databases
CTDi | 37142 |
FlyBasei | FBgn0266671, Sec6 |
VEuPathDBi | VectorBase:FBgn0266671 |
Phylogenomic databases
eggNOGi | KOG2286, Eukaryota |
GeneTreei | ENSGT01030000234613 |
HOGENOMi | CLU_016260_1_0_1 |
InParanoidi | Q9V8K2 |
OMAi | MNIGPKT |
OrthoDBi | 391172at2759 |
PhylomeDBi | Q9V8K2 |
Enzyme and pathway databases
Reactomei | R-DME-264876, Insulin processing R-DME-5620916, VxPx cargo-targeting to cilium |
SignaLinki | Q9V8K2 |
Miscellaneous databases
BioGRID-ORCSi | 37142, 0 hits in 3 CRISPR screens |
GenomeRNAii | 37142 |
PROi | PR:Q9V8K2 |
Gene expression databases
Bgeei | FBgn0266671, Expressed in embryonic/larval hemocyte (Drosophila) and 44 other tissues |
Genevisiblei | Q9V8K2, DM |
Family and domain databases
Gene3Di | 1.10.357.70, 1 hit |
InterProi | View protein in InterPro IPR010326, EXOC3/Sec6 IPR042532, EXOC3/Sec6_C |
PANTHERi | PTHR21292, PTHR21292, 1 hit |
Pfami | View protein in Pfam PF06046, Sec6, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EXOC3_DROME | |
Accessioni | Q9V8K2Primary (citable) accession number: Q9V8K2 Secondary accession number(s): Q95TT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2002 |
Last sequence update: | October 25, 2002 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families