Exocyst complex component 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• SNARE binding Source: FlyBase

GO - Biological processⁱ

• border follicle cell migration Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration."
    Assaker G., Ramel D., Wculek S.K., Gonzalez-Gaitan M., Emery G.
    Proc Natl Acad Sci U S A 107:22558-22563(2010) [PubMed] [Europe PMC] [Abstract]
• endocytic recycling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane."
    Langevin J., Morgan M.J., Sibarita J.B., Aresta S., Murthy M., Schwarz T., Camonis J., Bellaiche Y.
    Dev Cell 9:365-376(2005) [PubMed] [Europe PMC] [Abstract]
• exocyst localization Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• exocytosis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells."
    Beronja S., Laprise P., Papoulas O., Pellikka M., Sisson J., Tepass U.
    J Cell Biol 169:635-646(2005) [PubMed] [Europe PMC] [Abstract]
• Golgi to plasma membrane protein transport Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Sec6 mutations and the Drosophila exocyst complex."
    Murthy M., Ranjan R., Denef N., Higashi M.E., Schupbach T., Schwarz T.L.
    J Cell Sci 118:1139-1150(2005) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter secretion Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "A genome-wide search for synaptic vesicle cycle proteins in Drosophila."
    Lloyd T.E., Verstreken P., Ostrin E.J., Phillippi A., Lichtarge O., Bellen H.J.
    Neuron 26:45-50(2000) [PubMed] [Europe PMC] [Abstract]
• ovarian follicle cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches."
    Jia D., Soylemez M., Calvin G., Bornmann R., Bryant J., Hanna C., Huang Y.C., Deng W.M.
    Sci Rep 5:12328-12328(2015) [PubMed] [Europe PMC] [Abstract]
• plasma membrane organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells."
    Beronja S., Laprise P., Papoulas O., Pellikka M., Sisson J., Tepass U.
    J Cell Biol 169:635-646(2005) [PubMed] [Europe PMC] [Abstract]
• protein localization to cell cortex Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane."
    Langevin J., Morgan M.J., Sibarita J.B., Aresta S., Murthy M., Schwarz T., Camonis J., Bellaiche Y.
    Dev Cell 9:365-376(2005) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells."
    Beronja S., Laprise P., Papoulas O., Pellikka M., Sisson J., Tepass U.
    J Cell Biol 169:635-646(2005) [PubMed] [Europe PMC] [Abstract]
  • "Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane."
    Langevin J., Morgan M.J., Sibarita J.B., Aresta S., Murthy M., Schwarz T., Camonis J., Bellaiche Y.
    Dev Cell 9:365-376(2005) [PubMed] [Europe PMC] [Abstract]
• rhabdomere membrane biogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells."
    Beronja S., Laprise P., Papoulas O., Pellikka M., Sisson J., Tepass U.
    J Cell Biol 169:635-646(2005) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle docking Source: FlyBaseNon-traceable author statementⁱ
  • "A genome-wide search for synaptic vesicle cycle proteins in Drosophila."
    Lloyd T.E., Verstreken P., Ostrin E.J., Phillippi A., Lichtarge O., Bellen H.J.
    Neuron 26:45-50(2000) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle targeting Source: FlyBaseNon-traceable author statementⁱ
  • "A genome-wide search for synaptic vesicle cycle proteins in Drosophila."
    Lloyd T.E., Verstreken P., Ostrin E.J., Phillippi A., Lichtarge O., Bellen H.J.
    Neuron 26:45-50(2000) [PubMed] [Europe PMC] [Abstract]
• vesicle-mediated transport Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila."
    Littleton J.T.
    J. Cell Biol. 150:F77-F82(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• SNARE binding Source: FlyBase

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDLQQLEEQA RQAALKDIQN MLQRPGQLEK VEQYRHRIAR KKASVEALLK 
        60         70         80         90        100
TGMQGQLDGV RVGLKQLETC MQDVREVRRR MDEVERLLRG VPEVYDALEV 
       110        120        130        140        150
VREENTKHSQ YATAMENLKH IFNVDASVQK TMALIEDDKL LNAHQCLADL 
       160        170        180        190        200
ENSRDDLLYE LHKQPKQHAS DKITLKRHFE KVDTVSQELE KKLRLILSRT 
       210        220        230        240        250
LNTLRKKPTI IVTALRIIER EEKNDQFALQ QQKVTGFLPP GRPKAWRRMI 
       260        270        280        290        300
MDVLQQSVIT RIEGSKLEER ADNKMWLVRD LEILRQIILE DLRVVKSLCV 
       310        320        330        340        350
PCFPPHYDIF GEYVKFYHEG LSSYLDNIVR SGLEGNEYVS MMAWVTHTYP 
       360        370        380        390        400
GVELMSHPDL NVDVHRQIGT LLRPEHLKAL EDEYLQNMQR NFQEWMTKAA 
       410        420        430        440        450
ETEKQEWFTE TVPDQDEEYY HTSAPVIIFQ MIDQHLQVTN TIHQELTFKA 
       460        470        480        490        500
LVMSIQQVEI FGQTYLKNVI ELKEHHFRNR DQIKYFTHYI ITIVNNSQQM 
       510        520        530        540        550
VELAQQMKQL YWPKSRTEHY EDFERLLATF QRIRAHAASY LLEEAFLDME 
       560        570        580        590        600
CHFNDLFTAK WLASNIAVDT ICVTLDDYFQ DYNHLRPNNF EMVINEAQKL 
       610        620        630        640        650
LAKRYIRALL SKRLSKPRAE CDAITRKIKT EAKRFKLFFE KIAPKISLSD 
       660        670        680        690        700
SPLDLISTLS ALLSSDIELL VLDLHTLLGS YPSLNEDHLV RLFYIRNDVK 
       710        720        730 
AAEVREKVQD AMKSKKAMVS IAKQDCIFKE IVFSDKLW              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families