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Protein

Ragulator complex protein LAMTOR2 homolog

Gene

CG5189

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DME-1632852 Macroautophagy
R-DME-165159 mTOR signalling
R-DME-166208 mTORC1-mediated signalling
R-DME-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-5628897 TP53 Regulates Metabolic Genes
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation
R-DME-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2 homolog
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Gene namesi
ORF Names:CG5189
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034350 CG5189

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209631 – 125Ragulator complex protein LAMTOR2 homologAdd BLAST125

Proteomic databases

PaxDbiQ9V8I2
PRIDEiQ9V8I2

Expressioni

Gene expression databases

BgeeiFBgn0034350 Expressed in 3 organ(s), highest expression level in head
GenevisibleiQ9V8I2 DM

Interactioni

Subunit structurei

Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62798, 2 interactors
DIPiDIP-21855N
IntActiQ9V8I2, 2 interactors
STRINGi7227.FBpp0289083

Structurei

3D structure databases

ProteinModelPortaliQ9V8I2
SMRiQ9V8I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
InParanoidiQ9V8I2
KOiK20398
OMAiIWSAYEK
OrthoDBiEOG091G0W0V
PhylomeDBiQ9V8I2

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequencei

Sequence statusi: Complete.

Q9V8I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKPKALTQV LSQANTGGVE NTLLLSQEGA LLAYSGYGDK DARITAAIAS
60 70 80 90 100
NIWAAYEKHG RNAFREGRLT FVLIDCENGH VAITQVASVL LCLYAKQTVG
110 120
LGLLKQKAMS LASYLERPLK QISAS
Length:125
Mass (Da):13,439
Last modified:May 1, 2000 - v1
Checksum:i2C1E2A6199225AD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80H → L in AAR31126 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57685.1
AE013599 Genomic DNA Translation: ACL83153.1
BT011055 mRNA Translation: AAR31126.1
BT030774 mRNA Translation: ABV82156.1
BT058093 mRNA Translation: ACM86249.1
RefSeqiNP_001137699.1, NM_001144227.2
NP_611334.1, NM_137490.3
UniGeneiDm.6593

Genome annotation databases

EnsemblMetazoaiFBtr0086694; FBpp0085873; FBgn0034350
FBtr0299805; FBpp0289083; FBgn0034350
GeneIDi37122
KEGGidme:Dmel_CG5189
UCSCiCG5189-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57685.1
AE013599 Genomic DNA Translation: ACL83153.1
BT011055 mRNA Translation: AAR31126.1
BT030774 mRNA Translation: ABV82156.1
BT058093 mRNA Translation: ACM86249.1
RefSeqiNP_001137699.1, NM_001144227.2
NP_611334.1, NM_137490.3
UniGeneiDm.6593

3D structure databases

ProteinModelPortaliQ9V8I2
SMRiQ9V8I2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62798, 2 interactors
DIPiDIP-21855N
IntActiQ9V8I2, 2 interactors
STRINGi7227.FBpp0289083

Proteomic databases

PaxDbiQ9V8I2
PRIDEiQ9V8I2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086694; FBpp0085873; FBgn0034350
FBtr0299805; FBpp0289083; FBgn0034350
GeneIDi37122
KEGGidme:Dmel_CG5189
UCSCiCG5189-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0034350 CG5189

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
InParanoidiQ9V8I2
KOiK20398
OMAiIWSAYEK
OrthoDBiEOG091G0W0V
PhylomeDBiQ9V8I2

Enzyme and pathway databases

ReactomeiR-DME-1632852 Macroautophagy
R-DME-165159 mTOR signalling
R-DME-166208 mTORC1-mediated signalling
R-DME-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-5628897 TP53 Regulates Metabolic Genes
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation
R-DME-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

GenomeRNAii37122
PROiPR:Q9V8I2

Gene expression databases

BgeeiFBgn0034350 Expressed in 3 organ(s), highest expression level in head
GenevisibleiQ9V8I2 DM

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR2_DROME
AccessioniPrimary (citable) accession number: Q9V8I2
Secondary accession number(s): A8E6I2, B7YZK0, Q6NP73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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