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Protein

Pro-resilin

Gene

resilin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-resilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:resilin
ORF Names:CG15920
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034157 resilin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cuticle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Its strong elasticity suggests that it may be used for industrial and pharmaceutical applications. Recombinant protein can be cast into a rubber-like biomaterial by rapid photochemical cross-linking. The resilience (recovery after deformation) of cross-linked recombinant resilin exceeds that of unfilled synthetic polybutadiene, a high resilience rubber.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004284518 – 620Pro-resilinSequence analysisAdd BLAST603

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V7U0

PRoteomics IDEntifications database

More...
PRIDEi
Q9V7U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at pupal stage only.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034157 Expressed in 6 organ(s), highest expression level in head

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V7U0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62589, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086175

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9V7U0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 56Elastic 1Sequence analysisAdd BLAST15
Repeati57 – 77Elastic 2Sequence analysisAdd BLAST21
Repeati78 – 97Elastic 3Sequence analysisAdd BLAST20
Repeati98 – 112Elastic 4Sequence analysisAdd BLAST15
Repeati113 – 127Elastic 5Sequence analysisAdd BLAST15
Repeati128 – 145Elastic 6Sequence analysisAdd BLAST18
Repeati146 – 164Elastic 7Sequence analysisAdd BLAST19
Repeati165 – 179Elastic 8Sequence analysisAdd BLAST15
Repeati180 – 194Elastic 9Sequence analysisAdd BLAST15
Repeati195 – 210Elastic 10Sequence analysisAdd BLAST16
Repeati211 – 225Elastic 11Sequence analysisAdd BLAST15
Repeati226 – 244Elastic 12Sequence analysisAdd BLAST19
Repeati245 – 262Elastic 13Sequence analysisAdd BLAST18
Repeati263 – 276Elastic 14Sequence analysisAdd BLAST14
Repeati277 – 292Elastic 15Sequence analysisAdd BLAST16
Repeati293 – 307Elastic 16Sequence analysisAdd BLAST15
Repeati308 – 324Elastic 17Sequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini342 – 415Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 617Gly-richSequence analysisAdd BLAST584
Compositional biasi168 – 171Poly-SerSequence analysis4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2V1 Eukaryota
ENOG41128ZS LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V7U0

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGYSSGK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V7U0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031311 CHIT_BIND_RR_consensus
IPR000618 Insect_cuticle

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00379 Chitin_bind_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00233 CHIT_BIND_RR_1, 1 hit
PS51155 CHIT_BIND_RR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A1 Publication (identifier: Q9V7U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFKLLGLTLL MAMVVLGRPE PPVNSYLPPS DSYGAPGQSG PGGRPSDSYG
60 70 80 90 100
APGGGNGGRP SDSYGAPGQG QGQGQGQGGY AGKPSDTYGA PGGGNGNGGR
110 120 130 140 150
PSSSYGAPGG GNGGRPSDTY GAPGGGNGGR PSDTYGAPGG GGNGNGGRPS
160 170 180 190 200
SSYGAPGQGQ GNGNGGRSSS SYGAPGGGNG GRPSDTYGAP GGGNGGRPSD
210 220 230 240 250
TYGAPGGGNN GGRPSSSYGA PGGGNGGRPS DTYGAPGGGN GNGSGGRPSS
260 270 280 290 300
SYGAPGQGQG GFGGRPSDSY GAPGQNQKPS DSYGAPGSGN GNGGRPSSSY
310 320 330 340 350
GAPGSGPGGR PSDSYGPPAS GSGAGGAGGS GPGGADYDND EPAKYEFNYQ
360 370 380 390 400
VEDAPSGLSF GHSEMRDGDF TTGQYNVLLP DGRKQIVEYE ADQQGYRPQI
410 420 430 440 450
RYEGDANDGS GPSGPGGPGG QNLGADGYSS GRPGNGNGNG NGGYSGGRPG
460 470 480 490 500
GQDLGPSGYS GGRPGGQDLG AGGYSNGKPG GQDLGPGGYS GGRPGGQDLG
510 520 530 540 550
RDGYSGGRPG GQDLGASGYS NGRPGGNGNG GSDGGRVIIG GRVIGGQDGG
560 570 580 590 600
DQGYSGGRPG GQDLGRDGYS SGRPGGRPGG NGQDSQDGQG YSSGRPGQGG
610 620
RNGFGPGGQN GDNDGSGYRY
Note: No experimental confirmation available.Curated
Length:620
Mass (Da):58,604
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i432AFA06E54CB6BA
GO
Isoform B1 Publication (identifier: Q9V7U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-385: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:575
Mass (Da):53,526
Checksum:iD234139F8273427D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051872341 – 385Missing in isoform B. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57953.1
AE013599 Genomic DNA Translation: AAS64829.1
BT003322 mRNA Translation: AAO25082.1

NCBI Reference Sequences

More...
RefSeqi
NP_611157.1, NM_137313.4 [Q9V7U0-1]
NP_995860.1, NM_206138.2 [Q9V7U0-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.19192

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087024; FBpp0086175; FBgn0034157 [Q9V7U0-1]
FBtr0087025; FBpp0086176; FBgn0034157 [Q9V7U0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG15920

UCSC genome browser

More...
UCSCi
CG15920-RA d. melanogaster [Q9V7U0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57953.1
AE013599 Genomic DNA Translation: AAS64829.1
BT003322 mRNA Translation: AAO25082.1
RefSeqiNP_611157.1, NM_137313.4 [Q9V7U0-1]
NP_995860.1, NM_206138.2 [Q9V7U0-2]
UniGeneiDm.19192

3D structure databases

ProteinModelPortaliQ9V7U0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62589, 1 interactor
STRINGi7227.FBpp0086175

Proteomic databases

PaxDbiQ9V7U0
PRIDEiQ9V7U0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087024; FBpp0086175; FBgn0034157 [Q9V7U0-1]
FBtr0087025; FBpp0086176; FBgn0034157 [Q9V7U0-2]
GeneIDi36880
KEGGidme:Dmel_CG15920
UCSCiCG15920-RA d. melanogaster [Q9V7U0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36880
FlyBaseiFBgn0034157 resilin

Phylogenomic databases

eggNOGiENOG410J2V1 Eukaryota
ENOG41128ZS LUCA
InParanoidiQ9V7U0
OMAiQGYSSGK
PhylomeDBiQ9V7U0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
resilin fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36880

Protein Ontology

More...
PROi
PR:Q9V7U0

Gene expression databases

BgeeiFBgn0034157 Expressed in 6 organ(s), highest expression level in head
GenevisibleiQ9V7U0 DM

Family and domain databases

InterProiView protein in InterPro
IPR031311 CHIT_BIND_RR_consensus
IPR000618 Insect_cuticle
PfamiView protein in Pfam
PF00379 Chitin_bind_4, 1 hit
PROSITEiView protein in PROSITE
PS00233 CHIT_BIND_RR_1, 1 hit
PS51155 CHIT_BIND_RR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRESIL_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V7U0
Secondary accession number(s): Q86P83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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