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UniProtKB - Q9V7S5 (PICO_DROME)
Protein
Putative inorganic phosphate cotransporter
Gene
Picot
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be an inorganic phosphate cotransporter.
GO - Molecular functioni
- phosphate ion transmembrane transporter activity Source: InterPro
- symporter activity Source: UniProtKB-KW
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- anion transport Source: GO_Central
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Protein family/group databases
TCDBi | 2.A.1.14.34, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Putative inorganic phosphate cotransporter |
Gene namesi | Name:Picot ORF Names:CG8098 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0024315, Picot |
VEuPathDBi | VectorBase:FBgn0024315 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 429 – 449 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220946 | 1 – 529 | Putative inorganic phosphate cotransporterAdd BLAST | 529 |
Proteomic databases
PaxDbi | Q9V7S5 |
PRIDEi | Q9V7S5 |
PTM databases
SwissPalmi | Q9V7S5 |
Expressioni
Gene expression databases
Bgeei | FBgn0024315, Expressed in adult hindgut (Drosophila) and 40 other tissues |
ExpressionAtlasi | Q9V7S5, baseline and differential |
Genevisiblei | Q9V7S5, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 62577, 6 interactors |
DIPi | DIP-22400N |
STRINGi | 7227.FBpp0086261 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 495 – 529 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 502 – 529 | Polar residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2532, Eukaryota |
GeneTreei | ENSGT00940000173740 |
InParanoidi | Q9V7S5 |
OMAi | MRFLGYG |
PhylomeDBi | Q9V7S5 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004745, Pi_cotranspt |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00894, 2A0114euk, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform B (identifier: Q9V7S5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPFRRSSLNH RHRDGHVLVW NQRNLHESLE QQPQRCFATR YFVTFMLFLG
60 70 80 90 100
MANAYVMRTN MSVAIVAMVN HTAIKSGEAE EYDDECGDRD IPIDDSQDGE
110 120 130 140 150
FAWSSALQGY ILSSFFYGYV ITQIPFGILA KKYGSLRFLG YGMLINSVFA
160 170 180 190 200
FLVPVAARGG GVWGLCAVRF IQGLGEGPIV PCTHAMLAKW IPPNERSRMG
210 220 230 240 250
AAVYAGAQFG TIISMPLSGL LAEYGFDGGW PSIFYVFGIV GTVWSIAFLI
260 270 280 290 300
FVHEDPSSHP TIDEREKKYI NDSLWGTDVV KSPPIPFKAI IKSLPFYAIL
310 320 330 340 350
FAHMGHNYGY ETLMTELPTY MKQVLRFSLK SNGLLSSLPY LAMWLFSMFI
360 370 380 390 400
SVVADWMISS KRFSHTATRK LINSIGQYGP GVALIAASYT GCDRALTLAI
410 420 430 440 450
LTIGVGLNGG IYSGFKINHL DLTPRFAGFL MSITNCSANL AGLLAPIAAG
460 470 480 490 500
HLISDPSKPM MGQWQIVFFI AAFVYIICGT FYNIFGSGER QYWDNPEDDE
510 520
QKPALQTTVT TSPARLSNGS TAPAAISSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LFK0 | A0A0B4LFK0_DROME | Picot, isoform C | Picot Dmel\CG8098, MFS8, picot, CG8098, Dmel_CG8098 | 516 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007009 | 1 – 35 | MPFRR…QQPQR → MSASKEAICGSTEKDLEKPA LG in isoform A. CuratedAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57968.1 AE013599 Genomic DNA Translation: AAF57969.1 AY069501 mRNA Translation: AAL39646.1 AF022713 Genomic DNA Translation: AAD09148.1 |
RefSeqi | NP_001286496.1, NM_001299567.1 [Q9V7S5-2] NP_001286497.1, NM_001299568.1 [Q9V7S5-2] NP_611146.1, NM_137302.3 [Q9V7S5-2] NP_725600.1, NM_166187.2 [Q9V7S5-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0087114; FBpp0086260; FBgn0024315 [Q9V7S5-2] FBtr0087115; FBpp0086261; FBgn0024315 [Q9V7S5-1] FBtr0340067; FBpp0309073; FBgn0024315 [Q9V7S5-2] FBtr0340068; FBpp0309074; FBgn0024315 [Q9V7S5-2] |
GeneIDi | 36865 |
KEGGi | dme:Dmel_CG8098 |
UCSCi | CG8098-RA, d. melanogaster [Q9V7S5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF57968.1 AE013599 Genomic DNA Translation: AAF57969.1 AY069501 mRNA Translation: AAL39646.1 AF022713 Genomic DNA Translation: AAD09148.1 |
RefSeqi | NP_001286496.1, NM_001299567.1 [Q9V7S5-2] NP_001286497.1, NM_001299568.1 [Q9V7S5-2] NP_611146.1, NM_137302.3 [Q9V7S5-2] NP_725600.1, NM_166187.2 [Q9V7S5-1] |
3D structure databases
AlphaFoldDBi | Q9V7S5 |
SMRi | Q9V7S5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62577, 6 interactors |
DIPi | DIP-22400N |
STRINGi | 7227.FBpp0086261 |
Protein family/group databases
TCDBi | 2.A.1.14.34, the major facilitator superfamily (mfs) |
PTM databases
SwissPalmi | Q9V7S5 |
Proteomic databases
PaxDbi | Q9V7S5 |
PRIDEi | Q9V7S5 |
Protocols and materials databases
DNASUi | 36865 |
Genome annotation databases
EnsemblMetazoai | FBtr0087114; FBpp0086260; FBgn0024315 [Q9V7S5-2] FBtr0087115; FBpp0086261; FBgn0024315 [Q9V7S5-1] FBtr0340067; FBpp0309073; FBgn0024315 [Q9V7S5-2] FBtr0340068; FBpp0309074; FBgn0024315 [Q9V7S5-2] |
GeneIDi | 36865 |
KEGGi | dme:Dmel_CG8098 |
UCSCi | CG8098-RA, d. melanogaster [Q9V7S5-1] |
Organism-specific databases
CTDi | 36865 |
FlyBasei | FBgn0024315, Picot |
VEuPathDBi | VectorBase:FBgn0024315 |
Phylogenomic databases
eggNOGi | KOG2532, Eukaryota |
GeneTreei | ENSGT00940000173740 |
InParanoidi | Q9V7S5 |
OMAi | MRFLGYG |
PhylomeDBi | Q9V7S5 |
Miscellaneous databases
BioGRID-ORCSi | 36865, 0 hits in 1 CRISPR screen |
GenomeRNAii | 36865 |
PROi | PR:Q9V7S5 |
Gene expression databases
Bgeei | FBgn0024315, Expressed in adult hindgut (Drosophila) and 40 other tissues |
ExpressionAtlasi | Q9V7S5, baseline and differential |
Genevisiblei | Q9V7S5, DM |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004745, Pi_cotranspt |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00894, 2A0114euk, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PICO_DROME | |
Accessioni | Q9V7S5Primary (citable) accession number: Q9V7S5 Secondary accession number(s): O61364, Q8T077, Q9V7S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families