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UniProtKB - Q9V7G5 (C4AA1_DROME)
Protein
Probable cytochrome P450 4aa1
Gene
Cyp4aa1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
By similarityCofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 450 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
GO - Biological processi
- ecdysone biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Cyp4aa1 ORF Names:CG8302 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034053, Cyp4aa1 |
VEuPathDBi | VectorBase:FBgn0034053 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Peripheral membrane protein Curated
- Microsome membrane Curated; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051825 | 1 – 510 | Probable cytochrome P450 4aa1Add BLAST | 510 |
Proteomic databases
PaxDbi | Q9V7G5 |
PRIDEi | Q9V7G5 |
Expressioni
Gene expression databases
Bgeei | FBgn0034053, Expressed in crop (Drosophila) and 25 other tissues |
Genevisiblei | Q9V7G5, DM |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9V7G5 |
OMAi | VNNCVLD |
PhylomeDBi | Q9V7G5 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform B (identifier: Q9V7G5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFVEKVLERT TNLELCSILI LLVISLSIYT FYATLNTYLR SVLLSLRLTG
60 70 80 90 100
PPSLPFLGNC MLVTDKDLMR RCAGKAFDLY GSLVRIWVLL FPFFAVLEPE
110 120 130 140 150
DLQVILSSKK HTNKVFFYRL MHNFLGDGLI TSSGSKWSNH RRLIQPAFHH
160 170 180 190 200
NLLEKFIDTF VDASQSLYEN LDAEAVGTEI NIAKYVNNCV LDILNEAVLG
210 220 230 240 250
VPIKKRGQDV AMMEDSPFRQ GKIMMPARFT QPWLLLDGIY HWTKMANDEL
260 270 280 290 300
NQKKRLNDFT RKMIQRRRQI QNNNNGNSER KCLLDHMIEI SESNRDFTEE
310 320 330 340 350
DIVNEACTFM LAGQDSVGAA VAFTLFLLTQ NPECQDRCVL ELATIFEDSN
360 370 380 390 400
RAPTMTDLHE MRYMEMCIKE ALRLYPSVPL IARKLGEEVR LAKHTLPAGS
410 420 430 440 450
NVFICPYATH RLAHIYPDPE KFQPERFSPE NSENRHPYAF LPFSAGPRYC
460 470 480 490 500
IGNRFAIMEI KTIVSRLLRS YQLLPVTGKT TIAATFRITL RASGGLWVRL
510
KERDHPLIAH
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036909 | 348 – 375 | DSNRA…ALRLY → FLWGIYIYFLLKQCYICFIC NKVMLVGI in isoform A. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_036910 | 376 – 510 | Missing in isoform A. 1 PublicationAdd BLAST | 135 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58091.2 BT025154 mRNA Translation: ABE73324.1 |
RefSeqi | NP_611067.2, NM_137223.3 [Q9V7G5-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0114558; FBpp0113050; FBgn0034053 [Q9V7G5-1] |
GeneIDi | 36752 |
KEGGi | dme:Dmel_CG8302 |
UCSCi | CG8302-RB, d. melanogaster [Q9V7G5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58091.2 BT025154 mRNA Translation: ABE73324.1 |
RefSeqi | NP_611067.2, NM_137223.3 [Q9V7G5-1] |
3D structure databases
SMRi | Q9V7G5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0113050 |
Proteomic databases
PaxDbi | Q9V7G5 |
PRIDEi | Q9V7G5 |
Genome annotation databases
EnsemblMetazoai | FBtr0114558; FBpp0113050; FBgn0034053 [Q9V7G5-1] |
GeneIDi | 36752 |
KEGGi | dme:Dmel_CG8302 |
UCSCi | CG8302-RB, d. melanogaster [Q9V7G5-1] |
Organism-specific databases
CTDi | 36752 |
FlyBasei | FBgn0034053, Cyp4aa1 |
VEuPathDBi | VectorBase:FBgn0034053 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000166362 |
HOGENOMi | CLU_001570_5_1_1 |
InParanoidi | Q9V7G5 |
OMAi | VNNCVLD |
PhylomeDBi | Q9V7G5 |
Enzyme and pathway databases
Reactomei | R-DME-193144, Estrogen biosynthesis R-DME-211976, Endogenous sterols |
Miscellaneous databases
BioGRID-ORCSi | 36752, 0 hits in 1 CRISPR screen |
GenomeRNAii | 36752 |
PROi | PR:Q9V7G5 |
Gene expression databases
Bgeei | FBgn0034053, Expressed in crop (Drosophila) and 25 other tissues |
Genevisiblei | Q9V7G5, DM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C4AA1_DROME | |
Accessioni | Q9V7G5Primary (citable) accession number: Q9V7G5 Secondary accession number(s): Q1RKQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | April 14, 2009 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families