SH3 domain-binding protein 5 homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein kinase inhibitor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Rab guanyl-nucleotide exchange factor activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases."
    Riedel F., Galindo A., Muschalik N., Munro S.
    J Cell Biol 217:601-617(2018) [PubMed] [Europe PMC] [Abstract]
• SH3 domain binding Source: UniProtKB-KW

GO - Biological processⁱ

• anterior/posterior pattern specification Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]
• female germline ring canal formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Btk29A-mediated tyrosine phosphorylation of armadillo/beta-catenin promotes ring canal growth in Drosophila oogenesis."
    Hamada-Kawaguchi N., Nishida Y., Yamamoto D.
    PLoS One 10:e0121484-e0121484(2015) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mesoderm development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]
• muscle cell fate specification Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]
• muscle organ morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein tyrosine kinase activity Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster."
    Beckett K., Baylies M.K.
    Dev Biol 299:176-192(2006) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• Rab guanyl-nucleotide exchange factor activity Source: FlyBaseInferred from direct assayⁱ
  • "The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases."
    Riedel F., Galindo A., Muschalik N., Munro S.
    J Cell Biol 217:601-617(2018) [PubMed] [Europe PMC] [Abstract]
• SH3 domain binding Source: UniProtKB-KW

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSAEDGELD PQIQIELENL NSATDEINKL EIELEEANST FRILLNESTR 
        60         70         80         90        100
RLKVSSKKLG NCIEKARPYY EALDKAREAQ IECQKAAVKF QRANEIHAAA 
       110        120        130        140        150
KETVALAEQR FMSNSHEWQF DNAWQEMLNH ATQKVMDAET QKADCHAEHQ 
       160        170        180        190        200
RLTKLFNAAE QKLQQLEDRF RRSINKSRPY FEEKQVCQDQ LQTQKNRIQE 
       210        220        230        240        250
LQQQVAGAKS TYSTALRNLE RISEDIHRQR GDFPTPPGPR EPGVGAELNS 
       260        270        280        290        300
PTSSALPSLP DFQLELEKCD YPSIAGSQMS LGAKTPQAAA ETEDEEDACD 
       310        320        330        340        350
YDETGAGELR GVVDERDLEA LRQKVKILAV RPIEGGDGQQ QNDVWEHELK 
       360        370        380        390        400
ATVDKLDHLM MLKETAKRQQ TNRLKSTEQR PDSLGAEALK RHCDVVEVKV 
       410        420        430        440        450
TSCATTASLP VTPHHQLNHL APPTPIKKLQ QQLAPLPSVN VSMRELPLLA 
       460        470 
RLSNELLDRS SAAFGGVRKT LRRRSLE                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families